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- ACRF Cancer Biology and Stem Cells
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- Alistair Brown
- Anne-Laure Puaux
- Assoc Prof Joanna Groom
- Associate Profesor Ian Majewski
- Associate Professor Aaron Jex
- Associate Professor Andrew Webb
- Associate Professor Chris Tonkin
- Associate Professor Diana Hansen
- Associate Professor Edwin Hawkins
- Associate Professor Ethan Goddard-Borger
- Associate Professor Gemma Kelly
- Associate Professor Grant Dewson
- Associate Professor Isabelle Lucet
- Associate Professor James Vince
- Associate Professor Jason Tye-Din
- Associate Professor Jeff Babon
- Associate Professor Joan Heath
- Associate Professor John Wentworth
- Associate Professor Justin Boddey
- Associate Professor Kate Sutherland
- Associate Professor Kelly Rogers
- Associate Professor Marie-Liesse Asselin-Labat
- Associate Professor Melissa Call
- Associate Professor Misty Jenkins
- Associate Professor Nawaf Yassi
- Associate Professor Oliver Sieber
- Associate Professor Rachel Wong
- Associate Professor Rhys Allan
- Associate Professor Rosie Watson
- Associate Professor Ruth Kluck
- Associate Professor Shalin Naik
- Associate Professor Sumitra Ananda
- Associate Professor Tim Thomas
- Associate Professor Tracy Putoczki
- Chela Niall
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- Dr Alisa Glukhova
- Dr Anna Coussens
- Dr Ashley Ng
- Dr Belinda Phipson
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- Dr Hamish King
- Dr Hui-Li Wong
- Dr Jacqui Gulbis
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- Dr Matthew Call
- Dr Nadia Davidson
- Dr Nadia Kershaw
- Dr Philippe Bouillet
- Dr Rebecca Feltham
- Dr Rory Bowden
- Dr Samir Taoudi
- Dr Sarah Best
- Dr Saskia Freytag
- Dr Shabih Shakeel
- Dr Sheau Wen Lok
- Dr Stephin Vervoort
- Dr Yunshun Chen
- Guillaume Lessene
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- Joh Kirby
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- Professor Geoff Lindeman
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- Professor Ian Wicks
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- Professor Jeanne Tie
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- Professor Ken Shortman
- Professor Leanne Robinson
- Professor Leonard C Harrison
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- Professor Matthew Ritchie
- Professor Melanie Bahlo
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- Professor Mike Lawrence
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- Professor Peter Colman
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- Professor Phil Hodgkin
- Professor Sandra Nicholson
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- Diseases
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- A multi-pronged approach to targeting myeloproliferative neoplasms
- A new paradigm of machine learning-based structural variant detection
- A whole lot of junk or a treasure trove of discovery?
- Advanced imaging interrogation of pathogen induced NETosis
- Analysing the metabolic interactions in brain cancer
- Atopic dermatitis causes and treatments
- Boosting the efficacy of immunotherapy in lung cancer
- Building a cell history recorder using synthetic biology for longitudinal patient monitoring
- Characterisation of malaria parasite proteins exported into infected liver cells
- Deciphering the heterogeneity of the tissue microenvironment by multiplexed 3D imaging
- Defining the mechanisms of thymic involution and regeneration
- Delineating the molecular and cellular origins of liver cancer to identify therapeutic targets
- Developing computational methods for spatial transcriptomics data
- Developing drugs to block malaria transmission
- Developing models for prevention of hereditary ovarian cancer
- Developing statistical frameworks for analysing next generation sequencing data
- Development and mechanism of action of novel antimalarials
- Development of novel RNA sequencing protocols for gene expression analysis
- Discoveries in red blood cell production and function
- Discovering epigenetic silencing mechanisms in female stem cells
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Dissecting mechanisms of cytokine signalling
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- Epigenetic biomarkers of tuberculosis infection
- Epigenetics – genome wide multiplexed single-cell CUT&Tag assay development
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Exploiting the cell death pathway to fight Schistosomiasis
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- How do nutrition interventions and interruption of malaria infection influence development of immunity in sub-Saharan African children?
- Human lung protective immunity to tuberculosis
- Improving therapy in glioblastoma multiforme by activating complimentary programmed cell death pathways
- Innovating novel diagnostic tools for infectious disease control
- Integrative analysis of single cell RNAseq and ATAC-seq data
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigation of a novel cell death protein
- Malaria: going bananas for sex
- Mapping spatial variation in gene and transcript expression across tissues
- Mechanisms of Wnt secretion and transport
- Multi-modal computational investigation of single-cell communication in metastatic cancer
- Nanoparticle delivery of antibody mRNA into cells to treat liver diseases
- Naturally acquired immune response to malaria parasites
- Organoid-based discovery of new drug combinations for bowel cancer
- Organoid-based precision medicine approaches for oral cancer
- Removal of tissue contaminations from RNA-seq data
- Reversing antimalarial resistance in human malaria parasites
- Role of glycosylation in malaria parasite infection of liver cells, red blood cells and mosquitoes
- Screening for novel genetic causes of primary immunodeficiency
- Single-cell ATAC CRISPR screening – Illuminate chromatin accessibility changes in genome wide CRISPR screens
- Spatial single-cell CRISPR screening – All in one screen: Where? Who? What?
- Statistical analysis of single-cell multi-omics data
- Structural and functional analysis of epigenetic multi-protein complexes in genome regulation
- Structural basing for Wnt acylation
- Structure, dynamics and impact of extra-chromosomal DNA in cancer
- Targeted deletion of disease-causing T cells
- Targeting cell death pathways in tissue Tregs to treat inflammatory diseases
- The cellular and molecular calculation of life and death in lymphocyte regulation
- The role of hypoxia in cell death and inflammation
- The role of ribosylation in co-ordinating cell death and inflammation
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding cellular-cross talk within a tumour microenvironment
- Understanding the genetics of neutrophil maturation
- Understanding the roles of E3 ubiquitin ligases in health and disease
- Unveiling the heterogeneity of small cell lung cancer
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to understand malaria invasion and transmission
- Using structural biology to understand programmed cell death
- Validation and application of serological markers of previous exposure to malaria
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Scientific divisions

ACRF Chemical Biology
The ACRF Chemical Biology division aims to discover new medicines. We use structural, chemical and molecular biology approaches along with medicinal chemistry and high-throughput screening, to identify and validate novel therapeutic targets.
ACRF Cancer Biology and Stem Cells
The ACRF Cancer Biology and Stem Cells division is focused on breast, lung, ovarian and rare cancers.
We are working to understand normal organ development and the problems in this process that give rise to cancer, with a view to discovering new therapies.
Advanced Technology and Biology
Our division uses advanced and emerging technologies, along with powerful computational resources, to accelerate scientific discoveries.
With these tools we aim to obtain new insights into how diseases develop, spread and respond to treatment.
Bioinformatics
Scientists in the Bioinformatics division use methods from mathematics, statistics, and computer science to solve problems in medical research.
Our research includes developing new methods to analyse complex biomedical data as well as applying computational methods to discover fundamental processes in human health and disease.
Blood Cells and Blood Cancer
Our division investigates the processes that drive normal blood cell development.
We aim to identify the nature of defects that subvert these processes, causing the development of cancer.
Clinical Translation
Our team is led by clinician scientists who run research laboratories at the Institute and hold clinical appointments in Melbourne hospitals.
Epigenetics and Development
Researchers in our division study how cell growth and differentiation is regulated in normal development and in disease.
Our aim is to utilise this knowledge to identify potential new targets for therapy.
Immunology
Members of the Immunology division are dedicated to finding out how the immune system works and how it might be manipulated to achieve new disease treatments.
Infectious Diseases and Immune Defence
Our division aims to gain knowledge and make discoveries that will aid in the prevention, treatment and management of infectious diseases. The nature of our research spans laboratory work, field work, and testing new therapies all the way to the clinic.
Inflammation
Researchers in the Inflammation division are working to develop a detailed understanding of the triggers that promote inflammation and how this can lead to disease.
We aim to harness this knowledge to develop new diagnostics and treatments for inflammatory diseases.
Personalised Oncology
In the Personalised Oncology division clinicians and scientists are working together to reduce the impact of cancer in our community.
We aim to progress personalised strategies for the prevention, detection, diagnosis and treatment of cancer.
Population Health and Immunity
In our division we're applying advanced technologies to high-quality epidemiologic studies of human populations. This work enables us to uncover fundamental biological insights that can lead to the development of new tools for treatment and diagnosis.
Structural Biology
The Structural Biology division is interested in discovering new medicines through studies of the three-dimensional structure of large biological molecules that are either targets for drugs or potential therapeutic agents in their own right.
Ubiquitin Signalling
Our division is working to understand the underlying biology of ubiquitin-mediated processes in cells, with a particular focus on those associated with human diseases. A key aim is to enable translation of our ubiquitin research into clinical applications.