I am a group leader at WEHI, where I also completed my PhD.

During my PhD, I studied cell death, cytokine signalling and their roles in inflammation. I then moved to Munich, Germany, for my postdoctoral studies.

As a Marie-Curie fellow, I learned and applied state-of-the-art mass spectrometry to investigate cytokine signalling and cytokine-induced cell death in the lab of Prof Matthias Mann, one of the world’s leading proteomics laboratories.

I am passionate about leading my team to systematically investigate the body’s response to increased cell death during inflammation and infection using advanced high-sensitivity proteomics techniques.


Selected publications from Dr Maria Tanzer

1. Tanzer MC#, Bludau I, Stafford CA, Hornung V, Mann M#. Phosphoproteome profiling uncovers a key role for CDKs in TNF signalling. Nature Communications 2021 Oct DOI: 10.1038/s41467-021-26289-6. #Corresponding authors

2. Tanzer MC, Frauenstein A, Stafford CA, Phulphagar K, Mann M, Meissner F. Quantitative and dynamic catalogs of proteins differentially and commonly released during apoptotic and necroptotic cell death. Cell Reports 2020 Jan DOI: 10.1016/j.celrep.2019.12.079.

3. Hildebrand JM*, Tanzer MC*, Lucet IS, Young SN, Spall SK, Sharma P, Pierotti C, Garnier JM, Dobson RC, Webb AI, Tripaydonis A, Babon JJ, Mulcair MD, Scanlon MJ, Alexander WS, Wilks AF, Czabotar PE, Lessene G, Murphy JM, Silke J. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci USA. 2014 Oct DOI: 10.1073/pnas.1408987111. *equal contribution

4. Tanzer MC#. A proteomic perspective on TNF-mediated signalling and cell death. Biochem Soc Trans. 2022 Feb DOI 10.1042/BST20211114. #Corresponding author

5. Tanzer MC, Tripaydonis A, Webb AI, Young SN, Varghese LN, Hall C, Alexander WS, Hildebrand JM, Silke J, Murphy JM.Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop. Biochem J. 2015 Oct DOI: 10.1042/BJ20150678.

6. Tanzer MC, Matti I, Hildebrand JM, Young S, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM. Evolutionary divergence of the necroptosis effector MLKL. Cell Death Differ. 2016 Feb 12. DOI: 10.1038/cdd.2015.169.

7. Davies K*, Tanzer MC*, Griffin M, Mok YF, Young S, Qin R, Petrie E, Czabotar, Silke J, Murphy JM. The brace helices of MLKL mediate interdomain communication and oligomerization to regulate cell death by necroptosis. Cell Death and Differ. 2018 Feb DOI: 10.1038/s41418-018-0061-3. *equal contribution

8. Tanzer MC*, Khan N*, Rickard J, Etemadi N, Lalaoui N, Chau D, Vince JE, Wong WWL, McKinlay M, Chunduru SK, Benetatos CA, Condon SM, Vaux DL, Silke J. Combination of IAP antagonist and IFNγ activates novel caspase-10 and RIPK1 dependent cell death pathways. Cell Death and Differ. 2017 Jan 20. DOI: 10.1038/cdd.2016.147. *equal contribution

9. Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, Hamad SM, Piras A, Hansen FM, Tanzer MC, Zinzula L, Enghleitner T, Reinecke M, Lavacca TM, Ehmann R , Wölfel R, Jores J, Kuster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M and Pichlmair A. Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV. Nature 2021 June DOI: 10.1038/s41586-021-03493-4

10. Stafford CA, Gassauer A-M, Mann CCA, Tanzer MC, Fessler E, Wefers B, Nagl D, Kuut G, Sulek K, Vasilopoulou C, Schwojer SJ, Wiest A, Pfautsch MK, Wurst W, Yabal M, Fröhlich T, Mann M, Gisch N, Jae LT & Hornung V. Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation. Nature 2022 Sep. DOI:10.1038/s41586-022-05125-x


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