I am a group leader at WEHI, where I also completed my PhD.

During my PhD, I studied cell death, cytokine signalling and their roles in inflammation. I then moved to Munich, Germany, for my postdoctoral studies.

As a Marie-Curie fellow, I learned and applied state-of-the-art mass spectrometry to investigate cytokine signalling and cytokine-induced cell death in the lab of Prof Matthias Mann, one of the world’s leading proteomics laboratories.

I am passionate about leading my team to systematically investigate the body’s response to increased cell death during inflammation and infection using advanced high-sensitivity proteomics techniques.


Selected publications from Dr Maria Tanzer

1. Tanzer MC#, Tummers B#, Poon IKH#. Cell death: from its induction to the removal of dying cells!
Frontiers in Cell and Developmental Biology, Editorial 2023 Apr doi: 10.3389/fcell.2023.1195775
#Corresponding authors

2. Tanzer MC#. You are what you eat and how you digest it! A discussion on inflammatory efferocytosis.
Frontiers in Cell and Developmental Biology 2023 Feb doi: 10.3389/fcell.2023.1132696 #Corresponding author

3. Stafford CA, Gassauer A-M, Mann CCA, Tanzer MC, Fessler E, Wefers B, Nagl D, Kuut G, Sulek K, Vasilopoulou C, Schwojer SJ, Wiest A, Pfautsch MK, Wurst W, Yabal M, Fröhlich T, Mann M, Gisch N, Jae LT & Hornung V. Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
Nature 2022 Sep. doi: 10.1016/j.immuni.2022.10.021

4. Skowronek P, Thielert M, Voytik E, Tanzer MC, Hansen FM, Willems S, Karayel O, Brunnder AD, Meier F, Mann M. Rapid and in-depth coverage of the (Phospho-)Proteome with deep libraries and optimal window design for dia-PASEF.
Molecular and cellular proteomics 2022 Sep doi: 10.1016/j.mcpro.2022.100279

5. Bludau I, Willems S, Zeng WF, Strauss MT, Hansen FM, Tanzer MC, Karayel O, Schulman BA, Mann M. The structural context of PTMs at a proteome wide scale.
Plos Biology 2022 May doi: 10.1371/journal.pbio.3001636.

6. Tanzer MC#. A proteomic perspective on TNF-mediated signalling and cell death.
Biochem Soc Trans. 2022 Feb doi: 10.1042/BST20211114. #Corresponding author

7. Dichtl S, Sanin DE, Koss CK, Willenborg S, Petzold A, Tanzer MC, Dahl A, Kabat AM, Lindenthal L, Zeitler L, Satzinger S, Strasser A, Mann M, Roers A, Eming SA, Kasmi KCE, Pearce EJ, Murray PJ. Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF.
Life Sci Alliance 2022 Jan doi: 10.26508/lsa.202101315.

8. Tanzer MC#, Bludau I, Stafford CA, Hornung V, Mann M#. Phosphoproteome profiling uncovers a key role for CDKs in TNF signalling. #Corresponding authors
Nature Communications 2021 Oct doi: 10.1038/s41467-021-26289-6.

9. Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, Hamad SM, Piras A, Hansen FM, Tanzer MC, Zinzula L, Enghleitner T, Reinecke M, Lavacca TM, Ehmann R , Wölfel R, Jores J, Kuster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M and Pichlmair A. Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV. Nature 2021 June doi: 10.1038/s41586-021-03493-4

10. Hansen FM, Tanzer MC, Bruening F, Bludau I, Stafford C, Schulman BA, Robles MS, Karayel O, Mann M. Data-independent acquisition method for ubiqutinome analysis reveals regulation of circadian biology.
Nature Communications 2021 Jan doi: 10.1038/s41467-020-20509-1.

11. Pierotti CL, Tanzer MC, Jacobsen AV, Hildebrand JM, Garnier JM, Sharma P, Lucet IS, Cowan AD, Kersten WJA, Luo MX, Liang LY, Fitzgibbon C, Garnish SE, Hempel A, Nachbur U, Huang DCS, Czabotar PE, Silke J, van Delft MF, Murphy JM, Lessene G. Potent inhibition of necroptosis by simultaneously targeting multiple effectors of the pathway.
ACS Chem Biol. 2020 Sep doi: 10.1021/acschembio.0c00482.

12. Hildebrand JM, Kauppi M, Majewski IJ – Tanzer MC – Warren SA, Silke J.
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.
Nature Communications 2020 Jun doi: 10.1038/s41467-020-16819-z.

13. Tanzer MC, Frauenstein A, Stafford CA, Phulphagar K, Mann M, Meissner F. Quantitative and dynamic catalogs of proteins differentially and commonly released during apoptotic and necroptotic cell death.
Cell Reports 2020 Jan doi: 10.1016/j.celrep.2019.12.079.

14. Petrie EJ, Sandow JJ, Jacobsen AV, Smith BJ, Griffin MDW, Lucet IS, Dai W, Young SN, Tanzer MC, Wardak A, Liang LY, Cowan A, Hildebrand JM, Kersten W, Lessene G, Silke J, Czabotar PE, Webb AI, Murphy JM. Conformational switching of the human MLKL pseudokinase domain promotes MLKL tetramerization and cell death by necroptosis.
Nature Communications 2018 Jun doi: 10.1038/s41467-018-04714-7.

15. Davies K*, Tanzer MC*, Griffin M, Mok YF, Young S, Qin R, Petrie E, Czabotar, Silke J, Murphy JM. The brace helices of MLKL mediate interdomain communication and oligomerization to regulate cell death by necroptosis.
Cell Death and Differ. 2018 Feb doi: 10.1038/s41418-018-0061-3. *equal contribution

16. Kerr MC, Gomez GA, Ferguson C, Tanzer MC, Murphy JM, Yap AS, Parton RG, Huston WM, Teasdale JM. Calpain-mediated inclusion rupture regulates chlamydial egress and host cell necrosis.
Nature Communications. 2017 Mar doi: 10.1038/ncomms14729.

17. Tanzer MC*, Khan N*, Rickard J, Etemadi N, Lalaoui N, Chau D, Vince JE, Wong WWL, McKinlay M, Chunduru SK, Benetatos CA, Condon SM, Vaux DL, Silke J. Combination of IAP antagonist and IFNγ activates novel caspase-10 and RIPK1 dependent cell death pathways.
Cell Death and Differ. 2017 Jan 20. doi: 10.1038/cdd.2016.147. *equal contribution

18. Alvarez-Diaz S, Dillon, CP, Lalaoui, N, Tanzer MC, Rodriguez DA, Lin A, Lebois M, Hakem R, Josefsson EC, O’Reilly LA., Silke J, Alexander WS, Green DR, and Strasser A. The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.
Immunity 2016 Sep doi: 10.1016/j.immuni.2016.07.016.

19. Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J. The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.
Sci Transl Med. 2016 May doi: 10.1126/scitranslmed.aad3099.

20. Tanzer MC, Matti I, Hildebrand JM, Young S, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM. Evolutionary divergence of the necroptosis effector MLKL.
Cell Death Differ. 2016 Feb 12. doi: 10.1038/cdd.2015.169.

21. Jacobsen AV, Lowes KN, Tanzer MC, Lucet IS, Petrie EJ, van Delft M, Hildebrand JM, Huang DCS, Silke J, Lessene G, Murphy JM. HSP90 activity is required for translocation of MLKL to membranes and the induction of necroptotic cell death.
Cell Death Dis. 2016 Jan doi: 10.1038/cddis.2015.386.

22. Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekra W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth
GK, Vaux DL, Nutt SL, Nachbur U, Silke J. TRAF2 regulates TNF and NF-κB signaling to suppress apoptosis and skin inflammation independently of Sphingosine kinase-1.
Elife. 2015 Dec doi: 10.7554/eLife.10592.

23. Tanzer MC, Tripaydonis A, Webb AI, Young SN, Varghese LN, Hall C, Alexander WS, Hildebrand JM, Silke J, Murphy JM. Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.
Biochem J. 2015 Oct doi: 10.1042/BJ20150678.

24. Johnston AJ, Murphy KT, Jenkinson L, Laine D, Emmrich K, Faou P, Weston R, Jayatilleke KM, Schloegel J, Talbo G, Casey JL, Levina V, Wong WW, Dillon H, Sahay T, Hoogenraad J, Anderton H, Hall C, Schneider P, Tanzer M, Foley M, Scott AM, Gregorevic P, Liu SY, Burkly LC, Lynch GS, Silke J, Hoogenraad NJ. Targeting of Fn14 prevents cancer-induced Cachexia and prolongs survival.
Cell. 2015 Sep doi: 10.1016/j.cell.2015.08.031.

25. Baker PJ, Boucher D, Bierschenk D, Tebartz C, Whitney PG, D’Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K, Masters SL. NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
Eur. J. Immunolog. 2015 Jul doi: 10.1002/eji.201545655

26. Bock FJ, Tanzer MC, Haschka MD, Krumschnabel G, Sohm B, Goetsch K, Kofler R, Villunger A.The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death.
Sci. Rep. 2015 Jun doi: 10.1038/srep11268.

27. Hildebrand JM*, Tanzer MC*, Lucet IS, Young SN, Spall SK, Sharma P, Pierotti C, Garnier JM, Dobson RC, Webb AI, Tripaydonis A, Babon JJ, Mulcair MD, Scanlon MJ, Alexander WS, Wilks AF, Czabotar PE, Lessene G, Murphy JM, Silke J. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.
Proc Natl Acad Sci USA. 2014 Oct doi: 10.1073/pnas.1408987111. *equal contribution

28. Zhang Y, Kinkel S, Maksimovic J, Bandala-Sanchez E, Tanzer MC, Naselli G, Zhang J, Zhan Y, Silke J, Oshlack A, Blewitt ME and Harrison LC. The Polycomb repressive complex 2 component Ezh2 controls naïve CD4+ T cell differentiation and survival.
Blood 2014 Jul doi: 10.1182/blood-2013-12-544106.

29. Murphy JM, Lucet IS, Hildebrand JM, Tanzer MC, Young SN, Sharma P, Lessene G, Alexander WS, Babon JJ, Silke J, Czabotar PE. Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.
Biochem J. 2013 Nov 13 doi: 10.1042/BJ20131270

30. Manzl C, Fava LL, Krumschnabel G, Peintner L, Tanzer MC, Soratroi C, Bock FJ, Schuler F, Luef B, Geley S, Villunger A. Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.
Cell Death Dis. 2013 Dec doi: 10.1038/cddis.2013.470.

31. Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A. Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage.
Cell Death Differ. 2012 Dec doi: 10.1016/j.cell.2021.08.035.

32. Bock FJ, Peintner L, Tanzer M, Manzl C, Villunger A. P53- induced Protein with a Death Domain (PIDD) Master of Puppets?
Oncogene 2012 Nov doi: 10.1038/onc.2011.639

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