-
Areas
Technologies
Themes / Divisions

About

Professor Marie-Liesse Asselin-Labat PharmD, PhD, is Joint-Head of the Personalised Oncology division. She completed her PhD at the University Paris XI in 2004 and pursued post-doctoral work at WEHI before starting her independent research program in 2011.

Her lab focuses on studying the interactions between the immune micro-environment and tumour cells in lung cancer. Using spatial multi-omics approaches, she aims to identify targetable pathways to increase antitumour immunity in non-small lung cancer. Her team has shown that the immune environment in which a tumour arises is an important driver of immune evasion mechanisms (Cancer Cell 2023).

Drawing on her expertise in lung cancer biology, the analysis of clinical samples, immune evasion, the spatial analysis of the tumour microenvironment and functional screens, her research aims to increase our understanding of the evolutionary interactions driving immune evasion in lung cancer, and exploit these interactions as therapeutic targets.

Publications

Selected publications from Prof Marie-Liesse Labat

Leiwe M, Asselin-Labat M-L. The dynamics of the metastatic niche: Lung alveolar type 2 cell reprogramming and cancer cell stemness. Developmental Cell. 2024;59(18):10.1016/j.devcel.2024.07.014

VanderDoes J, Marceaux C, Yokote K, Asselin-Labat M-L, Rice G, Hywood JD. Using random forests to uncover the predictive power of distance-varying cell interactions in tumor microenvironments. PLOS Computational Biology. 2024;20(6):10.1371/journal.pcbi.1011361

Bhuva DD, Tan CW, Salim A, Marceaux C, Pickering MA, Chen J, Kharbanda M, Jin X, Liu N, Feher K, Putri G, Tilley WD, Hickey TE, Asselin-Labat M-L, Phipson B, Davis MJ. Library size confounds biology in spatial transcriptomics data. Genome Biology. 2024;25(1):10.1186/s13059-024-03241-7

Chaudhary P, Xu X, Wang G, Hoj JP, Rampersad RR, Asselin-Labat M-L, Ting S, Kim W, Tamayo P, Pendergast AM, Onaitis MW. Activation of KrasG12D in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma. Cancer Research Communications. 2023;3(11):10.1158/2767-9764.crc-22-0408

Malchers F, Nogova L, van Attekum MH, Maas L, Brägelmann J, Bartenhagen C, Girard L, Bosco G, Dahmen I, Michels S, Weeden CE, Scheel AH, Meder L, Golfmann K, Schuldt P, Siemanowski J, Rehker J, Merkelbach-Bruse S, Menon R, Gautschi O, Heuckmann JM, Brambilla E, Asselin-Labat M-L, Persigehl T, Minna JD, Walczak H, Ullrich RT, Fischer M, Reinhardt HC, Wolf J, Büttner R, Peifer M, George J, Thomas RK. Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer. Journal of Clinical Investigation. 2023;133(21):10.1172/jci170217

Rangamuwa K, Christie M, Leong T, Aloe C, Yokote K, Batey D, Asselin-Labat M-L, Antippa P, Irving L, Bozinovski S, Steinfort D. P1.09-01 Anti-Cancer Immune Activation Post Bronchoscopic Thermal Ablation in Non-Small Cell Lung Cancer. Journal of Thoracic Oncology. 2023;18(11):10.1016/j.jtho.2023.09.315

Weeden CE, Gayevskiy V, Marceaux C, Batey D, Tan T, Yokote K, Ribera NT, Clatch A, Christo S, Teh CE, Mitchell AJ, Trussart M, Rankin L, Obers A, McDonald JA, Sutherland KD, Sharma VJ, Starkey G, D’Costa R, Antippa P, Leong T, Steinfort D, Irving L, Swanton C, Gordon CL, Mackay LK, Speed TP, Gray DHD, Asselin-Labat M-L. Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer. Cancer Cell. 2023;41(5):10.1016/j.ccell.2023.03.019

Leong TL, Aloe C, Aujla S, Wang H, Gayevskiy V, Asselin-Labat M-L, Gray L-A, Steinfort D, Bozinovski S. Heterogeneity of tumour mutational burden in metastatic NSCLC demonstrated by endobronchial ultrasound sampling. Frontiers in Oncology. 2023;13:10.3389/fonc.2023.1150349

Rangamuwa K, Aloe C, Christie M, Asselin-Labat M-L, Batey D, Irving L, John T, Bozinovski S, Leong TL, Steinfort D. Methods for assessment of the tumour microenvironment and immune interactions in non-small cell lung cancer. A narrative review. Frontiers in Oncology. 2023;13:10.3389/fonc.2023.1129195

Balasubramanian A, John T, Asselin-Labat M-L. Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance. Biochemical Society Transactions. 2022;50(2):10.1042/bst20210961

Interested in supporting our research?

Your support will help WEHI’s researchers make discoveries and find treatments to ensure healthier, longer lives for you and your loved ones.

Contact our friendly team to find out how you can help.