My research aims to identify new and more effective treatments for individuals affected by cancers of the bowel, oral cavity and brain.

After gaining my PhD at Cancer Research UK in 2004, I undertook 6 years postdoctoral training at Cancer Research UK, the University of Oxford and the Ludwig Institute of Cancer Research (LICR Melbourne) in the field of cancer biology.

I was Joint Laboratory Head at the LICR Melbourne from 2009-12, before joining WEHI as Laboratory Head. At WEHI, I set up the Stafford Fox Centre for Cancer Stem Cell Disease Modelling to facilitate the development of precision medicine approaches for cancer utilising patient-derived organoids. I serve as Deputy Chair of the Translational Research Committee of the Australasian Gastro-Intestinal Trials Group (AGITG).

My research team integrates laboratory and clinical studies, working with academic and hospital partners, to advance our understanding of tumour biology and improve outcomes for bowel, oral and brain cancer.


Selected publications from A/Prof Oliver Sieber

1. Palmieri M, Catimel B, Mouradov D, Sakthianandeswaren A, Kapp E, Ang CS, Williamson NA, Nowell CJ, Christie M, Desai J, Gibbs P, Burgess AW, Sieber OM. PI3K-alpha translocation mediates nuclear PtdIns(3,4,5)P3 effector signaling in colorectal cancer. Molecular & Cellular Proteomics. 2023 Apr;22(4):100529. PMID: 36931626

2. Wang Z, Hu H, Heitink L, Rogers K, You Y, Tan T, Suen CLW, Garnham A, Chen H, Lieschke E, Diepstraten ST, Chang C, Chen T, Moujalled D, Sutherland K, Lessene G, Sieber OM, Visvader J, Kelly GL, Strasser A. The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells. Cell Death & Differentiation. 2023 Apr;30(4):1033-1046. PMID: 36739334

3. Mouradov D, Greenfield P, Li S, In EJ, Storey C, Sakthianandeswaren A, Georgeson P, Buchanan DD, Ward RL, Hawkins NJ, Skinner I, Jones IT, Gibbs P, Ma C, Liew YJ, Fung KYC, Sieber OM. Onco-microbial community profiling identifies clinico-molecular and prognostic subtypes of colorectal cancer. Gastroenterology. 2023 Mar 16:S0016-5085(23)00493-6. doi: 10.1053/j.gastro.2023.03.205. Online ahead of print. PMID: 36933623

4. Walker R, Georgeson P, Mahmood K, Joo JE, Makalic E, Clendenning M, Como J, Preston S, Joseland S, Pope BJ, Hutchinson RA, Kasem K, Walsh MD, Macrae FA, Win AK, Hopper JL, Mouradov D, Gibbs P, Sieber OM, O’Sullivan DE, Brenner DR, Gallinger S, Jenkins MA, Rosty C, Winship IM, Buchanan DD. Evaluating Multiple Next-Generation Sequencing-Derived Tumor Features to Accurately Predict DNA Mismatch Repair Status. Journal of Molecular Diagnostics. 2023 Feb;25(2):94-109. PMID: 36396080

5. Jenkins LJ, Luk IY, Fairlie WD, Lee EF, Palmieri M, Schoffer KL, Tan T, Ng I, Vukelic N, Tran S, Tse JWT, Nightingale R, Alam Z, Chionh F, Iatropoulos G, Ernst M, Afshar-Sterle S, Desai J, Gibbs P, Sieber OM, Dhillon AS, Tebbutt NC, Mariadason JM. Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death. Molecular Cancer Therapeutics. 2023 Jan 3;22(1):52-62. PMID: 36343387

6. Luk IY, Jenkins LJ, Schoffer KL, Ng I, Tse JWT, Mouradov D, Kaczmarczyk S, Nightingale R, Burrows AD, Anderson RL, Arango D, Dopeso H, Croft L, Richardson MF, Sieber OM, Liao Y, Mooi JK, Vukelic N, Reehorst CM, Afshar-Sterle S, Whitehall VLJ, Fennell L, Abud HE, Tebbutt NC, Phillips WA, Williams DS, Shi W, Mielke LA, Ernst M, Dhillon AS, Clemons NJ, Mariadason JM. Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression. Cell Death & Differentiation. 2022 Nov;29(11):2288-2302. PMID: 35606410

7. Gately L, Drummond K, Rosenthal M, Harrup R, Dowling A, Gogos A, Lwin Z, Collins I, Campbell D, Ahern E, Phillips C, Gan HK, Bennett I, Sieber OM, Gibbs P. Beyond standard data collection – the promise and potential of BRAIN (Brain tumour Registry Australia INnovation and translation registry). BMC Cancer. 2022 Jun 2;22(1):604. PMID: 35655179

8. Tan T, Hirokawa Y, Clarke J, Sakthianandeswaren A, Sieber OM. Low-viscosity Matrix Suspension Culture for Human Colorectal Epithelial Organoids and Tumoroids. Bio Protocol. 2022 Apr 20;12(8):e4394. PMID: 35800090

9. Georgeson P, Pope BJ, Rosty C, Clendenning M, Mahmood K, Jihoon E. Joo JE, Walker R, Ryan Hutchinson R, Preston S, Como J, Joseland S, Win AK, Finlay A. Macrae FA, Hopper JL, Mouradov D, Gibbs P, Sieber OM, O’Sullivan D, Mealey N, Brenner D, Gallinger S, Jenkins MA, Winship IM, Daniel D. Buchanan DD. Evaluating the utility of tumour mutational signatures for identifying hereditary colorectal cancer and polyposis syndrome carriers. Gut. 2021 Nov;70(11):2138-2149. PMID: 33414168

10. P Mittal, MR Condina, M Klingler-Hoffmann, G Kaur, MK Oehler, OM Sieber, M Palmieri, S Kommoss, S Brucker, MD McDonnell, P Hoffmann. Cancer Tissue Classification Using Supervised Machine Learning Applied to MALDI Mass Spectrometry Imaging. Cancers. 2021 Oct 27;13 (21), 5388. PMID: 34771551

Lab research projects

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