-
Areas
Diseases
Technologies

About

My research aims to identify new and more effective treatments for individuals affected by cancers of the bowel, oral cavity and brain.

After gaining my PhD at Cancer Research UK in 2004, I undertook 6 years postdoctoral training at Cancer Research UK, the University of Oxford and the Ludwig Institute of Cancer Research (LICR Melbourne) in the field of cancer biology.

I was Joint Laboratory Head at the LICR Melbourne from 2009-12, before joining WEHI as Laboratory Head. At WEHI, I set up the Stafford Fox Centre for Cancer Stem Cell Disease Modelling to facilitate the development of precision medicine approaches for cancer utilising patient-derived organoids. I serve as Deputy Chair of the Translational Research Committee of the Australasian Gastro-Intestinal Trials Group (AGITG).

My research team integrates laboratory and clinical studies, working with academic and hospital partners, to advance our understanding of tumour biology and improve outcomes for bowel, oral and brain cancer.

Publications

Selected publications from A/Prof Oliver Sieber

Al-Ani A, Pang J, Patel K, Young SN, Kong I, Chen JJ, Barrios M, Rickard J, Chen S, Foroughi S, Cawthorne W, Jacobsen A, Jois A, Weir A, Whitehead L, Rajasekhar P, Horne C, Azeez I, Zhang Y, Sieber O, Spelman T, Giulino-Roth L, Hawkins E, Rogers K, Bowden R, Nicholson S, Lawlor K, Samson AL, Vince JE, Murphy JM, Christensen B. DOP109 A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease. Journal of Crohn’s and Colitis. 2025;19(Supplement_1):10.1093/ecco-jcc/jjae190.0148

Storey C, Gately L, Drummond K, Gogos A, Mouradov D, Christie M, Brasier H, Priest E, Fakhri A, Gibbs P, Sieber O. TMOD-15. TOWARD BRAIN CANCER ORGANOID-INFORMED PRECISION MEDICINE FOR GLIOBLASTOMA. Neuro-Oncology. 2024;26(Supplement_8):10.1093/neuonc/noae165.1279

Brydon SC, Poad BLJ, Fang M, Rustam YH, Young RSE, Mouradov D, Sieber OM, Mitchell TW, Reid GE, Blanksby SJ, Marshall DL. Cross-Validation of Lipid Structure Assignment Using Orthogonal Ion Activation Modalities on the Same Mass Spectrometer. Journal of The American Society for Mass Spectrometry. 2024;35(8):10.1021/jasms.4c00221

Tan T, Mouradov D, Gibbs P, Sieber OM. Protocol for generation of and high-throughput drug testing with patient-derived colorectal cancer organoids. STAR Protocols. 2024;5(2):10.1016/j.xpro.2024.103090

Jenkins LJ, Luk IY, Chionh F, Tan T, Needham K, Ayton J, Reehorst CM, Vukelic N, Sieber OM, Mouradov D, Gibbs P, Williams DS, Tebbutt NC, Desai J, Hollande F, Dhillon AS, Lee EF, Merino D, Fairlie WD, Mariadason JM. BCL-XL inhibitors enhance the apoptotic efficacy of BRAF inhibitors in BRAFV600E colorectal cancer. Cell Death & Disease. 2024;15(3):10.1038/s41419-024-06478-z

Wang Z, Burigotto M, Ghetti S, Vaillant F, Tan T, Capaldo BD, Palmieri M, Hirokawa Y, Tai L, Simpson DS, Chang C, Huang AS, Lieschke E, Diepstraten ST, Kaloni D, Riffkin C, Huang DCS, Suen CSNLW, Garnham AL, Gibbs P, Visvader JE, Sieber OM, Herold MJ, Fava LL, Kelly GL, Strasser A. Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells. Cancer Discovery. 2024;14(2):10.1158/2159-8290.cd-23-0402

Tan T, Mouradov D, Lee M, Gard G, Hirokawa Y, Li S, Lin C, Li F, Luo H, Wu K, Palmieri M, Leong E, Clarke J, Sakthianandeswaren A, Brasier H, Tie J, Tebbutt NC, Jalali A, Wong R, Burgess AW, Gibbs P, Sieber OM. Unified framework for patient-derived, tumor-organoid-based predictive testing of standard-of-care therapies in metastatic colorectal cancer. Cell Reports Medicine. 2023;4(12):10.1016/j.xcrm.2023.101335

In E-J, Tan T, Mouradov D, Sakthianandeswaren A, Au A, Lowes K, Sieber O. Abstract C043: Discovery of new drug combinations for metastatic colorectal cancer. Molecular Cancer Therapeutics. 2023;22(12_Supplement):10.1158/1535-7163.targ-23-c043

Mouradov D, Greenfield P, Li S, In E-J, Storey C, Sakthianandeswaren A, Georgeson P, Buchanan DD, Ward RL, Hawkins NJ, Skinner I, Jones IT, Gibbs P, Ma C, Liew YJ, Fung KYC, Sieber OM. Oncomicrobial Community Profiling Identifies Clinicomolecular and Prognostic Subtypes of Colorectal Cancer. Gastroenterology. 2023;165(1):10.1053/j.gastro.2023.03.205

Palmieri M, Catimel B, Mouradov D, Sakthianandeswaren A, Kapp E, Ang C-S, Williamson NA, Nowell CJ, Christie M, Desai J, Gibbs P, Burgess AW, Sieber OM. PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)P3 Effector Signaling in Colorectal Cancer. Molecular & Cellular Proteomics. 2023;22(4):10.1016/j.mcpro.2023.100529

Lab research projects

Interested in supporting our research?

Your support will help WEHI’s researchers make discoveries and find treatments to ensure healthier, longer lives for you and your loved ones.

Contact our friendly team to find out how you can help.