A/Prof Oliver Sieber

Laboratory Head


We have a major focus on bowel cancer genomics, the application of high-throughput molecular profiling technologies to identify principal cancer genes and biomarkers of cancer risk and prognosis. We are conducting next-generation sequencing and microarray studies involving Australian and international patient cohorts to define molecular signatures associated with tumour characteristics and outcome.

Patient-focused investigations are being complemented with functional studies on cancer cell lines to distinguish driver from passenger mutations and to gain insights into molecular pathways of carcinogenesis. Molecularly-annotated cancer cell lines are further being used to explore the efficacy of novel drug therapies, both as single-agents and in combination with standard therapies.

We are developing organoids as ‘avatars’ of patient tumours to direct the use of therapies and to discover new treatment opportunities.


Selected publications from A/Prof Oliver Sieber

1. Palmieri M, Catimel B, Mouradov D, Sakthianandeswaren A, Kapp E, Ang CS, Williamson NA, Nowell CJ, Christie M, Desai J, Gibbs P, Burgess AW, Sieber OM. PI3K-alpha translocation mediates nuclear PtdIns(3,4,5)P3 effector signaling in colorectal cancer. Molecular & Cellular Proteomics. 2023 Apr;22(4):100529. PMID: 36931626

2. Wang Z, Hu H, Heitink L, Rogers K, You Y, Tan T, Suen CLW, Garnham A, Chen H, Lieschke E, Diepstraten ST, Chang C, Chen T, Moujalled D, Sutherland K, Lessene G, Sieber OM, Visvader J, Kelly GL, Strasser A. The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells. Cell Death & Differentiation. 2023 Apr;30(4):1033-1046. PMID: 36739334

3. Mouradov D, Greenfield P, Li S, In EJ, Storey C, Sakthianandeswaren A, Georgeson P, Buchanan DD, Ward RL, Hawkins NJ, Skinner I, Jones IT, Gibbs P, Ma C, Liew YJ, Fung KYC, Sieber OM. Onco-microbial community profiling identifies clinico-molecular and prognostic subtypes of colorectal cancer. Gastroenterology. 2023 Mar 16:S0016-5085(23)00493-6. doi: 10.1053/j.gastro.2023.03.205. Online ahead of print. PMID: 36933623

4. Walker R, Georgeson P, Mahmood K, Joo JE, Makalic E, Clendenning M, Como J, Preston S, Joseland S, Pope BJ, Hutchinson RA, Kasem K, Walsh MD, Macrae FA, Win AK, Hopper JL, Mouradov D, Gibbs P, Sieber OM, O’Sullivan DE, Brenner DR, Gallinger S, Jenkins MA, Rosty C, Winship IM, Buchanan DD. Evaluating Multiple Next-Generation Sequencing-Derived Tumor Features to Accurately Predict DNA Mismatch Repair Status. Journal of Molecular Diagnostics. 2023 Feb;25(2):94-109. PMID: 36396080

5. Jenkins LJ, Luk IY, Fairlie WD, Lee EF, Palmieri M, Schoffer KL, Tan T, Ng I, Vukelic N, Tran S, Tse JWT, Nightingale R, Alam Z, Chionh F, Iatropoulos G, Ernst M, Afshar-Sterle S, Desai J, Gibbs P, Sieber OM, Dhillon AS, Tebbutt NC, Mariadason JM. Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death. Molecular Cancer Therapeutics. 2023 Jan 3;22(1):52-62. PMID: 36343387

6. Luk IY, Jenkins LJ, Schoffer KL, Ng I, Tse JWT, Mouradov D, Kaczmarczyk S, Nightingale R, Burrows AD, Anderson RL, Arango D, Dopeso H, Croft L, Richardson MF, Sieber OM, Liao Y, Mooi JK, Vukelic N, Reehorst CM, Afshar-Sterle S, Whitehall VLJ, Fennell L, Abud HE, Tebbutt NC, Phillips WA, Williams DS, Shi W, Mielke LA, Ernst M, Dhillon AS, Clemons NJ, Mariadason JM. Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression. Cell Death & Differentiation. 2022 Nov;29(11):2288-2302. PMID: 35606410

7. Gately L, Drummond K, Rosenthal M, Harrup R, Dowling A, Gogos A, Lwin Z, Collins I, Campbell D, Ahern E, Phillips C, Gan HK, Bennett I, Sieber OM, Gibbs P. Beyond standard data collection – the promise and potential of BRAIN (Brain tumour Registry Australia INnovation and translation registry). BMC Cancer. 2022 Jun 2;22(1):604. PMID: 35655179

8. Tan T, Hirokawa Y, Clarke J, Sakthianandeswaren A, Sieber OM. Low-viscosity Matrix Suspension Culture for Human Colorectal Epithelial Organoids and Tumoroids. Bio Protocol. 2022 Apr 20;12(8):e4394. PMID: 35800090

9. Georgeson P, Pope BJ, Rosty C, Clendenning M, Mahmood K, Jihoon E. Joo JE, Walker R, Ryan Hutchinson R, Preston S, Como J, Joseland S, Win AK, Finlay A. Macrae FA, Hopper JL, Mouradov D, Gibbs P, Sieber OM, O’Sullivan D, Mealey N, Brenner D, Gallinger S, Jenkins MA, Winship IM, Daniel D. Buchanan DD. Evaluating the utility of tumour mutational signatures for identifying hereditary colorectal cancer and polyposis syndrome carriers. Gut. 2021 Nov;70(11):2138-2149. PMID: 33414168

10. P Mittal, MR Condina, M Klingler-Hoffmann, G Kaur, MK Oehler, OM Sieber, M Palmieri, S Kommoss, S Brucker, MD McDonnell, P Hoffmann. Cancer Tissue Classification Using Supervised Machine Learning Applied to MALDI Mass Spectrometry Imaging. Cancers. 2021 Oct 27;13 (21), 5388. PMID: 34771551

Lab research projects

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