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Areas

About

The Goddard-Borger laboratory studies the glycobiology of human diseases and works towards the development of new therapeutics using techniques in chemical, structural and molecular biology. Our research is highly collaborative, leading us to work closely with leading scientists at the institute, across Australia and around the world. This provides an excellent interdisciplinary training environment for students and postdoctoral researchers.

Publications

Selected publications from Prof Ethan Goddard

Burchill L, Sharma M, Soler NM, Goddard-Borger ED, Davies GJ, Williams SJ. Structure, kinetics, and mechanism of Pseudomonas putida sulfoquinovose dehydrogenase, the first enzyme in the sulfoglycolytic Entner-Doudoroff pathway. Biochemical Journal. 2025;482(02):10.1042/bcj20240605

Heydarchi B, D’Silva DB, Wong HL, Goddard-Borger ED, Wicks IP. Fc mutagenesis enhances the functionality of anti-RhD monoclonal antibodies. Blood Advances. 2024;:10.1182/bloodadvances.2024015082

Li J, Mui JW-Y, da Silva BM, Pires DEV, Ascher DB, Madiedo Soler N, Goddard-Borger ED, Williams SJ. A Broad-Spectrum α-Glucosidase of Glycoside Hydrolase Family 13 from Marinovum sp., a Member of the Roseobacter Clade. Applied Biochemistry and Biotechnology. 2024;196(9):10.1007/s12010-023-04820-3

Arumapperuma T, Snow AJD, Lee M, Sharma M, Zhang Y, Lingford JP, Goddard-Borger ED, Davies GJ, Williams SJ. Capture-and-release of a sulfoquinovose-binding protein on sulfoquinovose-modified agarose. Organic & Biomolecular Chemistry. 2024;22(16):10.1039/d4ob00307a

Li J, Sharma M, Meek R, Alhifthi A, Armstrong Z, Soler NM, Lee M, Goddard-Borger ED, Blaza JN, Davies GJ, Williams SJ. Correction: Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum. Chemical Science. 2024;15(2):10.1039/d3sc90238b

Kaur A, Pickles IB, Sharma M, Soler NM, Scott NE, Pidot SJ, Goddard-Borger ED, Davies GJ, Williams SJ. Widespread Family of NAD+‑Dependent Sulfoquinovosidases at the Gateway to Sulfoquinovose Catabolism. Journal of the American Chemical Society. 2023;145(51):10.1021/jacs.3c11126

Sharma M, Kaur A, Soler NM, Lingford JP, Epa R, Goddard-Borger ED, Davies GJ, Williams SJ. Defining the molecular architecture, metal dependence, and distribution of metal-dependent class II sulfofructose-1-phosphate aldolases. Journal of Biological Chemistry. 2023;299(11):10.1016/j.jbc.2023.105338

Li J, Sharma M, Meek R, Alhifthi A, Armstrong Z, Soler NM, Lee M, Goddard-Borger ED, Blaza JN, Davies GJ, Williams SJ. Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum. Chemical Science. 2023;14(41):10.1039/d3sc01594g

Bloch JS, John A, Mao R, Mukherjee S, Boilevin J, Irobalieva RN, Darbre T, Scott NE, Reymond J-L, Kossiakoff AA, Goddard-Borger ED, Locher KP. Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nature Chemical Biology. 2023;19(5):10.1038/s41589-022-01219-9

Arumapperuma T, Li J, Hornung B, Soler NM, Goddard-Borger ED, Terrapon N, Williams SJ. A subfamily classification to choreograph the diverse activities within glycoside hydrolase family 31. Journal of Biological Chemistry. 2023;299(4):10.1016/j.jbc.2023.103038

Lab research projects

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