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About

Dr Dagley completed her PhD in Biochemistry and Molecular Biology in 2014 at The University of Melbourne/Bio21 Institute with Prof Tony Purcell but spent most of her PhD on exchange at the University of Toronto, Canada with Prof Andrew Emili.

She has over 13 years’ experience in the application of novel mass spectrometry and proteomics technologies to address key research questions in the fields of infectious and inflammatory diseases and cancer. Since 2021, Laura has been the Head of the Proteomics facility where she leads a multidisciplinary team of 5 research staff and oversees an instrument platform consisting of 6 mass spectrometers, 7 liquid chromatography instruments and an automated robot for hydrogen deuterium exchange (HDX).

She has received several nationally-competitive awards including the Ken Mitchelhill Award from the Australasian Proteomics Society, and several peer-reviewed competitive research grants from the NH&MRC and the AMP Foundation.

She has several productive research collaborations with researchers both internally and externally resulting in 8 first/co-first author publications in leading journals (including Nature Immunology). Laura has also developed key experimental capabilities within the Proteomics facility including co-immunoprecipitation MS, high-throughput sample processing and biomarker discovery in human biofluids.

Visit the Proteomics facility page for detailed information.

 

 

More information

Publications

Selected publications from Dr Laura Dagley

1. Dagley, L. F., Infusini, G., Larsen, R. H., Sandow, J. J., Webb, A. I. Universal Solid-Phase Protein Preparation (USP(3)) for Bottom-up and Top-down Proteomics. (2019) J Proteome Res 18(7): 2915-2924.

2. Rautela, J.*, Dagley, L.F.*, de Oliveira, C.C., Schuster, I.S., Hediyeh-Zadeh, S., Delconte R.B., Cursons J., et al. Therapeutic blockade of activin-A improves NK cell function and antitumor immunity. (2019) Sci Signal. 2(596): eaat7527 * JOINT FIRST AUTHOR

3. Ju Y., Kelly H.G., Dagley L.F., Reynaldi A., Schlub T.E., Spall S.K., et al. Person-Specific Biomolecular Coronas Modulate Nanoparticle Interactions with Immune Cells in Human Blood. (2020) ACS Nano 14(11):15723-37.

4. Louis C., Souza-Fonseca-Guimaraes F., Yang Y., D’Silva D., Kratina T., Dagley L., Hediyeh-Zadeh S., Rautela J., Masters S.L., Davis M.J., Babon J.J., Ciric B., Vivier E., Alexander W.S., Huntington N.D., Wicks I.P. NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (2020) J Exp Med. 217(5):e20191421

5. Marapana, D.S., Dagley, L.F., Sandow, J.J., Nebl, T., Triglia, T., Pasternak, M., Dickerman, B.K., Crabb, B., Gilson, P.R., Webb, A.I., Boddey, J.A., Cowman, A.F. Plasmepsin V cleaves malaria effector proteins in a distinct ER translocation interactome for export to the erythrocyte. (2018) Nat Microbiol. 3(9): 1010-1022.

6. Triglia, T., Scally, S.W., Seager, B.A., Pasternak, M., Dagley, L.F., and Cowman, A.F. Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion. Nat Commun 14, 2219. (2023) 10.1038/s41467-023-37890-2.

7. Steiner, A. Hrovat-Schaale, K., Prigione, I., Yu, C.H., Laohamonthonkul, P., Harapas, C.R., Low, R.R.J., De Nardo, D., Dagley, L.F. et al. Deficiency in coatomer complex I causes aberrant activation of STING signalling. Nat Commun. 13, 2321 (2022).

8. O’Donnell L*, Rebourcet D*, Dagley L.F.*, Sgaier R, Infusini G, O’Shaughnessy PJ, et al. Sperm proteins and cancer-testis antigens are released by the seminiferous tubules in mice and men. (2021) FASEB J. 35(3):e21397 * JOINT FIRST AUTHOR

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