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About

I studied Biochemistry in Melbourne at La Trobe University where I completed my bachelors with honours, and undertook a PhD in drug discovery and inflammation. La Trobe has an exceptional biochemistry program, and I was thrilled to be accepted and be part of it. I then made the leap across to London for four years to continue my research at the Institute of Cancer Research, where I got to be part of a fantastic lab and where I learnt many critical skills. I then accepted a position as Laboratory Head at WEHI in 2020 and I now lead a team of 10 incredible scientists, 4 post-doctoral researchers, 5 PhD students and 1 RA to target ‘undruggable’ inflammatory proteins.

My team is highly motivated, has a fierce intellect and collaborate extensively nationally and internationally to achieve our scientific goals.

Our most recent achievement has been the introduction of an innovative drug discovery technology to WEHI and we are the leaders behind the development, integration and uptake of this technology amongst the larger biosciences sector across Australia.

Publications

Selected publications from Dr Bekky Feltham

Anderton H, Bandala-Sanchez E, Simpson DS, Rickard JA, Ng AP, Di Rago L, Hall C, Vince JE, Silke J, Liccardi G, Feltham R. Correction to: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development. Cell Death & Differentiation. 2024;:10.1038/s41418-024-01401-7

Simpson DS, Anderton H, Yousef J, Vaibhav V, Cobbold SA, Bandala-Sanchez E, Kueh AJ, Dagley LF, Herold MJ, Silke J, Vince JE, Feltham R. Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death. PNAS Nexus. 2023;3(1):10.1093/pnasnexus/pgad438

Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SS, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE. Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications. 2023;14(1):10.1038/s41467-023-42706-4

Chen H, Nguyen NH, Magtoto CM, Cobbold SA, Bidgood GM, Guzman LGM, Richardson LW, Corbin J, Au AE, Lechtenberg BC, Feltham R, Sutherland KD, Grohmann C, Nicholson SE, Sleebs BE. Design and characterization of a heterobifunctional degrader of KEAP1. Redox Biology. 2023;59:10.1016/j.redox.2022.102552

Frank D, Garnish SE, Sandow JJ, Weir A, Liu L, Clayer E, Meza L, Rashidi M, Cobbold SA, Scutts SR, Doerflinger M, Anderton H, Lawlor KE, Lalaoui N, Kueh AJ, Eng VV, Ambrose RL, Herold MJ, Samson AL, Feltham R, Murphy JM, Ebert G, Pearson JS, Vince JE. Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death. iScience. 2022;25(7):10.1016/j.isci.2022.104632

Grohmann C, Magtoto CM, Walker JR, Chua NK, Gabrielyan A, Hall M, Cobbold SA, Mieruszynski S, Brzozowski M, Simpson DS, Dong H, Dorizzi B, Jacobsen AV, Morrish E, Silke N, Murphy JM, Heath JK, Testa A, Maniaci C, Ciulli A, Lessene G, Silke J, Feltham R. Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms. Nature Communications. 2022;13(1):10.1038/s41467-022-29670-1

Simpson DS, Pang J, Weir A, Kong IY, Fritsch M, Rashidi M, Cooney JP, Davidson KC, Speir M, Djajawi TM, Hughes S, Mackiewicz L, Dayton M, Anderton H, Doerflinger M, Deng Y, Huang AS, Conos SA, Tye H, Chow SH, Rahman A, Norton RS, Naderer T, Nicholson SE, Burgio G, Man SM, Groom JR, Herold MJ, Hawkins ED, Lawlor KE, Strasser A, Silke J, Pellegrini M, Kashkar H, Feltham R, Vince JE. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity. 2022;55(3):10.1016/j.immuni.2022.01.003

Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SS, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE. Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications. 2021;12(1):10.1038/s41467-021-26983-5

Vijayaraj SL, Feltham R, Rashidi M, Frank D, Liu Z, Simpson DS, Ebert G, Vince A, Herold MJ, Kueh A, Pearson JS, Dagley LF, Murphy JM, Webb AI, Lawlor KE, Vince JE. The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation. Nature Communications. 2021;12(1):10.1038/s41467-021-22979-3

Magtoto CM, Feltham R. K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2VHL. Molecular Cell. 2021;81(7):10.1016/j.molcel.2021.02.030

Lab research projects

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