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About

In the laboratory, we study how the master controller of systemic iron homoestasis, hepcidin, is regulated. Hepcidin is responsible for controlling iron absorption from the intestine and iron recycling from degraded red cells by the macrophage.

We are using novel epigenetic approaches to characterise new pathways which may regulate hepcidin gene expression. In addition, we are studying mechanisms by which erythropoiesis and anaemia may affect hepcidin expression.

In the field, we are undertaking large randomised controlled trials of iron interventions in rural Bangladesh (infants) and Malawi (pregnant women). These trials will provide much needed evidence to inform global health anaemia control policies. Samples from these trials will be available for analysis using cutting edge platforms including 16S rRNA gene sequencing for microbiota, CyTOF and flow cytometry, and molecular characterization, for example using high throughput RNA sequencing.

Finally, we assist and advise international and national organisations with research and policy development.

Publications

Selected publications from Prof Sant-Rayn Pasricha

2024;

Castro OL, De Franceschi L, Ganz T, Kanter J, Kato GJ, Pasricha S, Rivella S, Wood JC. Iron restriction in sickle cell disease: When less is more. American Journal of Hematology. 2024;99(7):10.1002/ajh.27267

Casal MNG, Rogers LM, Pasricha S-R. Updated WHO Guidelines on the Assessment of Haemoglobin and Cutoffs for Defining Anaemia. Current Developments in Nutrition. 2024;8:10.1016/j.cdnut.2024.102942

Fielding KL, Braat S, Pasricha S-R. The effects of upward revision of haemoglobin thresholds for anaemia in blood donations – Authors’ reply. The Lancet Haematology. 2024;11(6):10.1016/s2352-3026(24)00112-1

Pasricha S-R, Rogers L, Branca F, Garcia-Casal M-N. Measuring haemoglobin concentration to define anaemia: WHO guidelines. The Lancet. 2024;403(10440):10.1016/s0140-6736(24)00502-6

Braat S, Fielding KL, Han J, Jackson VE, Zaloumis S, Xu JXH, Moir-Meyer G, Blaauwendraad SM, Jaddoe VWV, Gaillard R, Parkin PC, Borkhoff CM, Keown-Stoneman CDG, Birken CS, Maguire JL, Team GHR, Bahlo M, Davidson EM, Pasricha S-R. Haemoglobin thresholds to define anaemia from age 6 months to 65 years: estimates from international data sources. The Lancet Haematology. 2024;11(4):10.1016/s2352-3026(24)00030-9

Ahmed S, Hasan MI, Rahman AMQ, Bhuiyan MSA, Tipu SMMU, Braat S, McLean ARD, Arifeen SE, Hamadani JD, Pasricha S-R, Davidson EM. Prevalence and determinants of anaemia during the second or third trimester of pregnancy in Bangladesh: a cross-sectional study protocol. Gates Open Research. 2024;8:10.12688/gatesopenres.15120.1

Pasricha S-R, Moya E, Ataide R, Mzembe G, Harding R, Phiri K. The REVAMP trial: key questions remain – Authors’ reply. The Lancet. 2024;403(10421):10.1016/s0140-6736(23)01915-3

Manda-Taylor L, Kufankomwe M, Chatha G, Chipeta E, Mamani-Mategula E, Mwangi MN, Kelaher M, Prang K-H, Ataíde R, Pasricha S-R, Phiri KS. Perceptions and experiences of intravenous iron treatment for anaemia in pregnancy in Malawi: a formative qualitative study. Gates Open Research. 2024;6:10.12688/gatesopenres.13631.4

Goncalves I, Lewis C, Grainger B, Dring R, Lee N, Pasricha S-R, Szer J, Mason K. Thrombosis in patients with immune thrombocytopenia: incidence, risk, and clinical outcomes. Research and Practice in Thrombosis and Haemostasis. 2024;8(1):10.1016/j.rpth.2024.102342

Lab research projects

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