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About

The focus of my lab is to understand how immune signals are interpreted by lymphocytes to generate protective immunity. To investigate this problem we take a quantitative approach, using computer models to describe and measure individual components of the immune response. This allows us to accurately measure the contribution of immune signals, or genetic variation on the effectiveness of the lymphocyte function. Conversely, we can use the same theory to investigate how therapeutic interventions can be applied to target individual pathways, or components of the model, that are defective in immune disorders.

Therefore, my laboratory has two arms. One is to apply models to study lymphocyte function as described above, while the second is to construct and test new models. We do this through a combination of quantitative in vitro analysis integrated with single cell imaging techniques both in vitro and in vivo.

Publications

Selected publications from A/Prof Edwin Hawkins

Tye H, Conos SA, Djajawi TM, Gottschalk TA, Abdoulkader N, Kong IY, Kammoun HL, Narayana VK, Kratina T, Speir M, Emery J, Simpson DS, Hall C, Vince AJ, Russo S, Crawley R, Rashidi M, Hildebrand JM, Murphy JM, Whitehead L, De Souza DP, Masters SL, Samson AL, Lalaoui N, Hawkins ED, Murphy AJ, Vince JE, Lawlor KE. Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice. Life Science Alliance. 2025;8(1):10.26508/lsa.202302446

Chiou S, Cawthorne W, Soerianto T, Hofferek V, Patel KM, Garnish SE, Tovey Crutchfield EC, Hall C, Hildebrand JM, McConville MJ, Lawlor KE, Hawkins ED, Samson AL, Murphy JM. MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions. Cell Death & Disease. 2024;15(11):10.1038/s41419-024-07242-z

Atkin-Smith GK, Santavanond JP, Light A, Rimes JS, Samson AL, Er J, Liu J, Johnson DN, Le Page M, Rajasekhar P, Yip RKH, Geoghegan ND, Rogers KL, Chang C, Bryant VL, Margetts M, Keightley MC, Kilpatrick TJ, Binder MD, Tran S, Lee EF, Fairlie WD, Ozkocak DC, Wei AH, Hawkins ED, Poon IKH. In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions. Nature Communications. 2024;15(1):10.1038/s41467-024-52867-5

Todorovski I, Tsang M-J, Feran B, Fan Z, Gadipally S, Yoannidis D, Kong IY, Bjelosevic S, Rivera S, Voulgaris O, Zethoven M, Hawkins ED, Simpson KJ, Arnau GM, Papenfuss AT, Johnstone RW, Vervoort SJ. RNA kinetics influence the response to transcriptional perturbation in leukaemia cell lines. NAR Cancer. 2024;6(4):10.1093/narcan/zcae039

Lieschke E, Thomas AF, Kueh A, Atkin-Smith GK, Baldoni PL, La Marca JE, Young S, Huang AS, Ross AM, Whelan L, Kaloni D, Tai L, Smyth GK, Herold MJ, Hawkins ED, Strasser A, Kelly GL. Mouse models to investigate in situ cell fate decisions induced by p53. The EMBO Journal. 2024;43(19):10.1038/s44318-024-00189-z

Chiou S, Al-Ani AH, Pan Y, Patel KM, Kong IY, Whitehead LW, Light A, Young SN, Barrios M, Sargeant C, Rajasekhar P, Zhu L, Hempel A, Lin A, Rickard JA, Hall C, Gangatirkar P, Yip RK, Cawthorne W, Jacobsen AV, Horne CR, Martin KR, Ioannidis LJ, Hansen DS, Day J, Wicks IP, Law C, Ritchie ME, Bowden R, Hildebrand JM, O’Reilly LA, Silke J, Giulino-Roth L, Tsui E, Rogers KL, Hawkins ED, Christensen B, Murphy JM, Samson AL. An immunohistochemical atlas of necroptotic pathway expression. EMBO Molecular Medicine. 2024;16(7):10.1038/s44321-024-00074-6

Speir M, Tye H, Gottschalk TA, Simpson DS, Djajawi TM, Deo P, Ambrose RL, Conos SA, Emery J, Abraham G, Pascoe A, Hughes SA, Weir A, Hawkins ED, Kong I, Herold MJ, Pearson JS, Lalaoui N, Naderer T, Vince JE, Lawlor KE. A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation. EMBO Reports. 2023;24(11):10.15252/embr.202356865

Mosteo L, Rocha L, Maceiras AR, Cavadas B, Pereira C, Lopes M, Chacim S, Ramos I, Hawkins E, Mariz JM, Porto G, Duarte D. P481: FAILURE OF BONE MARROW ERYTHROPOIESIS IN ACUTE MYELOID LEUKEMIA IS DRIVEN BY LOSS OF ERYTHROBLASTIC ISLANDS. HemaSphere. 2023;7(Suppl):10.1097/01.hs9.0000968832.21173.fa

Trezise S, Kong IY, Hawkins ED, Herold MJ, Willis SN, Nutt SL. An arrayed CRISPR screen of primary B cells reveals the essential elements of the antibody secretion pathway. Frontiers in Immunology. 2023;14:10.3389/fimmu.2023.1089243

Kong IY, Trezise S, Light A, Todorovski I, Arnau GM, Gadipally S, Yoannidis D, Simpson KJ, Dong X, Whitehead L, Tempany JC, Farchione AJ, Sheikh AA, Groom JR, Rogers KL, Herold MJ, Bryant VL, Ritchie ME, Willis SN, Johnstone RW, Hodgkin PD, Nutt SL, Vervoort SJ, Hawkins ED. Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis. Cell Death & Differentiation. 2022;29(12):10.1038/s41418-022-01037-5

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