A/Prof Naiyang Fu, Lab Head | WEHI Researcher Profile

About

Dr Naiyang Fu obtained his Bachelor of Science at Xiamen University (China), and then his Master of Science at Sun Yat-sen University (China). He subsequently completed his PhD study at the Institute of Molecular and Cell Biology (IMCB) / National University of Singapore (NUS). After his postdoctoral training at WEHI, he returned to Singapore and has been appointed as a Laboratory Head at the Duke-NUS Medical School since 2016. He currently holds an adjoint faculty appointment at WEHI and Duke-NUS.

His research has unmasked novel cellular and molecular mechanisms underpinning normal development, regeneration and tumorigenesis in epithelial tissues, including breast, skin and liver. His laboratory at WEHI focuses on delineating the molecular and cellular origins in liver cancer for identification of novel biomarkers and therapeutic targets for this malignant disease. To this end, they combine cutting edge technologies in molecular biology, single-cell profiling, organoids, 3D imaging and mouse genetic approaches for their research.

The ultimate goal of his research is to provide novel insights into prevention, diagnosis and treatment of cancer.

Joint appointments

Publications

Selected publications from A/Prof Naiyang Fu

Cho Y-L, Tan HWS, Yang J, Kuah BZM, Lim NSY, Fu N, Bay B-H, Ling S-C, Shen H-M. Glucose-6-phosphate dehydrogenase regulates mitophagy by maintaining PINK1 stability. Life Metabolism. 2025;:10.1093/lifemeta/loae040

Ang CH, Arandjelovic P, Cheng J, Yang J, Guo F, Yu Y, Nelameham S, Whitehead L, Li J, Silver DL, Barker N, Visvader JE, Chow PKH, Smyth GK, Chen Y, Virshup DM, Fu NY. Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries. Cell Reports. 2024;44(1):10.1016/j.celrep.2024.115093

Goh KY, Lee WX, Choy SM, Priyadarshini GK, Chua K, Tan QH, Low SY, San Chin H, Wong CS, Huang S-Y, Fu NY, Nishiyama J, Harmston N, Tang H-W. FOXO-regulated DEAF1 controls muscle regeneration through autophagy. Autophagy. 2024;20(12):10.1080/15548627.2024.2374693

Yang J, Zhang Z, Lam JSW, Fan H, Fu NY. Molecular Regulation and Oncogenic Functions of TSPAN8. Cells. 2024;13(2):10.3390/cells13020193

Yang X, Xu H, Yang X, Wang H, Zou L, Yang Q, Qi X, Li L, Duan H, Yan X, Fu NY, Tan J, Hou Z, Jiao B. Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling. Nature Communications. 2024;15(1):10.1038/s41467-023-44338-0

Ahn M, Chen VC-W, Rozario P, Ng WL, Kong PS, Sia WR, Kang AEZ, Su Q, Nguyen LH, Zhu F, Chan WOY, Tan CW, Cheong WS, Hey YY, Foo R, Guo F, Lim YT, Li X, Chia WN, Sobota RM, Fu NY, Irving AT, Wang L-F. Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases. Cell. 2023;186(10):10.1016/j.cell.2023.03.036

Yang J, Guo F, Chin HS, Chen GB, Ang CH, Lin Q, Hong W, Fu NY. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Cell Reports. 2023;42(2):10.1016/j.celrep.2023.112065

Nguyen PHD, Wasser M, Tan CT, Lim CJ, Lai HLH, Seow JJW, DasGupta R, Phua CZJ, Ma S, Yang J, Suthen SDO, Tam WL, Lim TKH, Yeong J, Leow WQ, Pang YH, Soon G, Loh TJ, Wan WK, Chan CY, Cheow PC, Toh HC, Kow A, Dan YY, Kam JH, Iyer S, Madhavan K, Chung A, Bonney GK, Goh BKP, Fu N, Yu VC, Zhai W, Albani S, Chow PKH, Chew V. Trajectory of immune evasion and cancer progression in hepatocellular carcinoma. Nature Communications. 2022;13(1):10.1038/s41467-022-29122-w

Yu H, He J, Su G, Wang Y, Fang F, Yang W, Gu K, Fu N, Wang Y, Shen Y, Liu X. Fluid shear stress activates YAP to promote epithelial–mesenchymal transition in hepatocellular carcinoma. Molecular Oncology. 2021;15(11):10.1002/1878-0261.13061

Tan CT, Chang H-C, Zhou Q, Yu C, Fu NY, Sabapathy K, Yu VC. MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling. EMBO Reports. 2021;22(1):10.15252/embr.202050854