Dr Naiyang Fu obtained his Bachelor of Science at Xiamen University (China), and then his Master of Science at Sun Yat-sen University (China). He subsequently completed his PhD study at the Institute of Molecular and Cell Biology (IMCB) / National University of Singapore (NUS). After his postdoctoral training at WEHI, he returned to Singapore and has been appointed as a Laboratory Head at the Duke-NUS Medical School since 2016. He currently holds an adjoint faculty appointment at WEHI and Duke-NUS.

His research has unmasked novel cellular and molecular mechanisms underpinning normal development, regeneration and tumorigenesis in epithelial tissues, including breast, skin and liver. His laboratory at WEHI focuses on delineating the molecular and cellular origins in liver cancer for identification of novel biomarkers and therapeutic targets for this malignant disease. To this end, they combine cutting edge technologies in molecular biology, single-cell profiling, organoids, 3D imaging and mouse genetic approaches for their research.

The ultimate goal of his research is to provide novel insights into prevention, diagnosis and treatment of cancer.


Selected publications from A/Prof Naiyang Fu

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.
J Yang, F Guo, H San Chin, GB Chen, CH Ang, Q Lin, W Hong, NY Fu
Cell Reports (2023), 42 (2): 112065.

Trajectory of immune evasion and cancer progression in hepatocellular carcinoma.
Nguyen PHD…. Fu NY, Yu CV, Zhai W, Albani S, Chow PKH and Chew V. Trajectory of immune evasion and cancer progression in Hepatocellular carcinoma,
Nature Communications (2022), 13 (1): 1441.

Physiological Functions of Mcl-1: insights from genetic mouse models.
Chin HS and Fu NY.
Front. Cell Dev. Biol (2021). 9:704547. doi: 10.3389/fcell.2021.704547.

MOAP‐1‐mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling
CT Tan, HC Chang, Q Zhou, C Yu, NY Fu, K Sabapathy, VC Yu
EMBO reports (2021), 22 (1): e50854

Halting triple negative breast cancer by targeting PROCR.
Fu NY, Visvader JE.
Cell Research (2019), 29: 875-876.

Stem cells and the differentiation hierarchy in mammary gland development.
Fu N, Nolan E, Lindeman GJ, Visvader JE.
Physiol Rev (2019), 100: 489-523

Lgr5+ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis.
Ang CH, Hsu SH, Guo F, Tan CT, Yu VC, Visvader JE, Chow PKH, Fu NY*.
PNAS (2019), 116(39): 19530-19540.

Foxp1 is indispensable for ductal morphogenesis and controls the exit of mammary stem cells from quiescence.
Fu NY*, Pal B, Chen Y, Jackling FC, Milevskiy M, Vaillant F, Capaldo BD, Guo F, Liu KH, Rios AC, Lim N, Kueh AJ, Virshup DM, Herold MJ, Tucker HO, Smyth GK, Lindeman GJ, Visvader JE*.
Developmental Cell (2018), 47: 629-644. (Cover Story and Featured Article; *Corresponding authors)

Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive.
Fu NY*, Rios AC*, Pal B, Law CW, Jamieson P, Liu R, Vaillant F, Jackling F, Liu
KH, Smyth GK, Lindeman GJ, Ritchie ME, Visvader JE.
Nature Cell Biology (2017), 19: 164-176. (*Joint first author; Article)

The complexities and caveats of lineage tracing in the mammary gland.
Rios AC*, Fu NY*, Cursons J, Lindeman GJ, Visvader JE.
Breast Cancer Research (2016), 18: 116. (*Joint first author)

MOAP-1 mediates Fas-induced apoptosis in liver by facilitating tBid recruitment to mitochondria.
Tan CT, Zhou QL, Su YC, Fu NY, Chang HC, Tao RN, Sukumaran SK, Baksh S, Tan YJ, Sabapathy K, Yu CD, Yu VC.
Cell Reports (2016), 16:174-185.

Essential role for a novel population of binucleated mammary epithelial cells in lactation.
Rios AC*, Fu NY*, Jamieson PR, Pal B, Whitehead L, Nicholas KR, Lindeman GJ, Visvader JE.
Nature Communications (2016), 7:11400. (*Joint first author)

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival.
Fu NY, Rios AC, Pal B, Soetanto R, Lun AT, Liu K, Beck T, Best SA, Vaillant F, Bouillet P, Strasser A, Preiss T, Smyth GK, Lindeman GJ, Visvader JE.
Nature Cell Biology (2015), 17: 365-375. (Article; highlighted on the cover of the issue)

In situ identification of bipotent stem cells in the mammary gland.
Rios AC*, Fu NY*, Lindeman GJ and Visvader JE.
Nature (2014), 506: 322-327. (*Joint first author; Article)

Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2.
Pal B, Bouras T, Shi W, Vaillant F, Sheridan JM, Fu NY, Breslin K, Jiang K, Ritchie ME, Young M, Lindeman GJ, Smyth GK and Visvader JE.
Cell Reports (2013), 3: 411-426.

A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.
Sukumaran SK, Fu NY, Chua BT, Lee SS, Wan KF and Yu VC.
Molecular Cell (2010), 37: 768-783.

Baxβ: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism.
Fu NY, Sukumaran SK, Kerk SY and Yu VC.
Molecular Cell (2009), 33: 15-29. (Featured Article in the issue)

Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria.
Fu NY, Sukumaran SK. and Yu VC.
PNAS (2007), 104: 10051-10057.

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