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Diseases
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Themes / Divisions

About

My research interest is in developing personalized therapies for brain cancer, through the advanced investigation of the molecular features of cancer. This expertise, together with Dr Sarah Best (personalised oncology) and Dr Jim Whittle (clinical) provides the multidisciplinary foundations of the Brain Cancer Research Laboratory.

The research interests of the lab include:
– Research that is patient-centred and informed by consumers
– Integrating advanced diagnostics together with clinical data to discover new biomarkers
– Applying deep learning to identify prognostic biomarkers
– Developing new pre-clinical models of brain cancer
– Dissecting glioma heterogeneity and its microenvironment
– Identifying existing drugs for repurposing in brain cancer
– Establishing innovative clinical trial design strategies to progress new treatments and combinations for patients
– Support and collaboration across brain cancer research fields

Publications

Selected publications from Dr Saskia Freytag

Herring CA, Simmons RK, Freytag S, Poppe D, Moffet JJD, Pflueger J, Buckberry S, Vargas-Landin DB, Clément O, Echeverría EG, Sutton GJ, Alvarez-Franco A, Hou R, Pflueger C, McDonald K, Polo JM, Forrest ARR, Nowak AK, Voineagu I, Martelotto L, Lister R. Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution. Cell. 2022;185(23):10.1016/j.cell.2022.09.039

Freytag S, Lister R. schex avoids overplotting for large single-cell RNA-sequencing datasets. Bioinformatics. 2020;36(7):10.1093/bioinformatics/btz907

Freytag S, Tian L, Lönnstedt I, Ng M, Bahlo M. Comparison of clustering tools in R for medium-sized 10x Genomics single-cell RNA-sequencing data. F1000Research. 2018;7:10.12688/f1000research.15809.1

Freytag S, Burgess R, Oliver KL, Bahlo M. brain-coX: investigating and visualising gene co-expression in seven human brain transcriptomic datasets. Genome Medicine. 2017;9(1):10.1186/s13073-017-0444-y

Cain SA, Topp M, Rosenthal M, Tobler R, Freytag S, Best SA, Whittle JR, Drummond KJ. A perioperative study of Safusidenib in patients with IDH1-mutated glioma. Future Oncology. 2024;ahead-of-print(ahead-of-print):10.1080/14796694.2024.2383064

Bertlich M, Hartmann D, Freytag S, French LE, Oppel E. Sensitization against medical hyaluronidase in patients with confirmed hypersensitivity against hymenoptera species and its clinical implications. British Journal of Dermatology. 2024;:10.1093/bjd/ljae290

Moffet J, Kriel J, Lu T, Freytag L, Whittle J, Best S, Freytag S. Abstract 5498: Multi-modal examination of spatial heterogeneity in the astrocytoma microenvironment. Cancer Research. 2024;84(6_Supplement):10.1158/1538-7445.am2024-5498

Brown DV, Anttila CJA, Ling L, Grave P, Baldwin TM, Munnings R, Farchione AJ, Bryant VL, Dunstone A, Biben C, Taoudi S, Weber TS, Naik SH, Hadla A, Barker HE, Vandenberg CJ, Dall G, Scott CL, Moore Z, Whittle JR, Freytag S, Best SA, Papenfuss AT, Olechnowicz SWZ, MacRaild SE, Wilcox S, Hickey PF, Amann-Zalcenstein D, Bowden R. A risk-reward examination of sample multiplexing reagents for single cell RNA-Seq. Genomics. 2024;116(2):10.1016/j.ygeno.2024.110793

Swain T, Pflueger C, Freytag S, Poppe D, Pflueger J, Nguyen TV, Li JK, Lister R. A modular dCas9-based recruitment platform for combinatorial epigenome editing. Nucleic Acids Research. 2024;52(1):10.1093/nar/gkad1108

Bertlich M, Freytag S, Huber P, Dombrowski T, Oppel E, Gröger M. Serological Cross-Reactivity of Various Aspergillus spp. with Aspergillus fumigatus: A Diagnostic Blind Spot. International Archives of Allergy and Immunology. 2024;185(8):10.1159/000538082

Moffet J, Fatunla O, Whittle J, Jordan J, Roberts-Thomson S, Pavenko A, Scoville D, Zhang L, Liang Y, Morokoff A, Freytag S, Best S. TMIC-36. SPATIAL ARCHITECTURE OF HIGH-GRADE GLIOMA REVEALS TUMOR HETEROGENEITY WITHIN DISTINCT DOMAINS. Neuro-Oncology. 2023;25(Supplement_5):10.1093/neuonc/noad179.1102

Lu T, Freytag L, Narayana VK, Moore Z, Oliver SJ, Valkovic A, Nijagal B, Peterson AL, de Souza DP, McConville MJ, Whittle JR, Best SA, Freytag S. Matrix Selection for the Visualization of Small Molecules and Lipids in Brain Tumors Using Untargeted MALDI-TOF Mass Spectrometry Imaging. Metabolites. 2023;13(11):10.3390/metabo13111139

Borger JG, Ng AP, Anderton H, Ashdown GW, Auld M, Blewitt ME, Brown DV, Call MJ, Collins P, Freytag S, Harrison LC, Hesping E, Hoysted J, Johnston A, McInneny A, Tang P, Whitehead L, Jex A, Naik SH. Artificial intelligence takes center stage: exploring the capabilities and implications of ChatGPT and other AI‐assisted technologies in scientific research and education. Immunology and Cell Biology. 2023;101(10):10.1111/imcb.12689

Dewdney B, Jenkins MR, Best SA, Freytag S, Prasad K, Holst J, Endersby R, Johns TG. From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progress. Signal Transduction and Targeted Therapy. 2023;8(1):10.1038/s41392-023-01637-8

Lab research projects

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