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About

Our research is focused on understanding the biological events involved in the inflammatory response to gluten in people with coeliac disease and gluten-related disorders. We employ a range of immunological techniques to study this response and collaborate with scientists in the fields of cereal science, structural biology, protein chemistry, microbiome and omics technologies, as well as clinicians and public health specialists. We work closely with industry partners to ensure our research can be translated to the clinic, and the involvement of the national patient association organisation Coeliac Australia helps keep our goals relevant to the needs of people with coeliac disease.

Publications

Selected publications from A/Prof Jason Tye-Din

Daveson AJM, Stubbs R, Polasek TM, Isola J, Anderson R, Tye-Din JA, Schoeman M, Lionnet C, Mei SLCY, Mihajlović J, Wirth M, Peelen E, Schreieck A, Kohlhof H, Vitt D, Muehler A, Buriánek F. Safety, clinical activity, pharmacodynamics, and pharmacokinetics of IMU-856, a SIRT6 modulator, in coeliac disease: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet Gastroenterology & Hepatology. 2025;10(1):10.1016/s2468-1253(24)00248-6

Adams DW, Moleski S, Jossen J, Tye-Din JA. Reply. Gastroenterology. 2024;167(6):10.1053/j.gastro.2024.07.019

Haynes A, Tully A, Smith GJ, Penno MAS, Craig ME, Wentworth JM, Huynh T, Colman PG, Soldatos G, Anderson AJ, McGorm KJ, Oakey H, Couper JJ, Davis EA, Barry SC, Craig ME, Colman PG, Couper JJ, Davis EA, Hamilton-Williams E, Harrison LC, Haynes A, Huynh T, Kim KW, Morahan G, Oakey H, Penno MAS, Rawlinson WD, Sinnott RO, Soldatos G, Thomson RL, Tye-Din J, Vuillermin PJ, Wentworth JM, Cameron F, Day A, Lopez P, Anderson AJ, Ashwood P, Brown JD, Hu W, Huynh D, McGorm KJ, Watson K, Beresford S, Bezuidenhout D, Brandrick S, Butterworth C, Catteau J, Griffiths H, Gwiazdzinski A, Hall C, Hulley A, Henneken L, Kludas R, Mateevici Y, Ramoso B, Roberts A, Tully A, Wood R, Binkowski S, Bui M, Gilbert A, Huang D, Karceva A, Mellor B-R, Naselli G, Ngui K, Nguyen T, Patel B, Prajitno V, Stone N, Tran T, Vaega S, Ward E, Xu Y, Yau C, Battersby R, Brittain B, Foster C, Hope C, Leung P, Mallitt K-A, Roth-Schulze A, Sadlon T, Tillett B, Walker G, Wong Y, Zozaya-Valdes E, Cavenett L. Early Dysglycemia Is Detectable Using Continuous Glucose Monitoring in Very Young Children at Risk of Type 1 Diabetes. Diabetes Care. 2024;47(10):10.2337/dc24-0540

Thomson RL, Oakey H, Haynes A, Craig ME, Harrison LC, Wentworth JM, Anderson A, Ashwood P, Barry S, Brittain B, Brown JD, Colman PG, Davis EA, Hamilton-Williams E, Huynh D, Huynh T, Kim K-W, McGorm KJ, Morahan G, Rawlinson W, Sinnott RO, Soldatos G, Tye-Din JA, Vuillermin PJ, Penno MAS, Couper JJ. Environmental Determinants of Islet Autoimmunity (ENDIA) longitudinal prospective pregnancy to childhood cohort study of Australian children at risk of type 1 diabetes: parental demographics and birth information. BMJ Open Diabetes Research & Care. 2024;12(4):10.1136/bmjdrc-2024-004130

Saitta D, Henneken LM, Apputhurai P, Chen Yi Mei SL, Tye-Din JA. Budesonide Induces Favourable Histologic and Symptomatic Recovery in Patients with Non-responsive and Refractory Coeliac Disease When Given in an Open Capsule Format. Digestive Diseases and Sciences. 2024;69(7):10.1007/s10620-024-08436-3

Hardy MY, Henneken LM, Russell AK, Okura Y, Mizoroki A, Ozono Y, Kobayashi S, Murakami Y, Tye-Din JA. A bispecific antibody targeting HLA-DQ2.5-gluten peptides potently blocks gluten-specific T cells induced by gluten ingestion in patients with celiac disease. Clinical Immunology. 2024;264:10.1016/j.clim.2024.110259

Saitta D, Henneken LM, Apputhurai P, Chen Yi Mei SL, Tye-Din JA. Correction to: Budesonide Induces Favourable Histologic and Symptomatic Recovery in Patients with Non-responsive and Refractory Coeliac Disease When Given in an Open Capsule Format. Digestive Diseases and Sciences. 2024;69(7):10.1007/s10620-024-08510-w

Tye‐Din JA. Evolution in coeliac disease diagnosis and management. JGH Open. 2024;8(7):10.1002/jgh3.13107

Silvester JA, Elli L, Khosla C, Tye-Din JA. Past, Present, and Future of Noninvasive Tests to Assess Gluten Exposure, Celiac Disease Activity, and End-Organ Damage. Gastroenterology. 2024;167(1):10.1053/j.gastro.2024.01.053

Henneken LM, Loh TJ, Ciacchi L, Ciacchi L, Lim J, Reid HH, Tye‐Din JA. Bridging science and accessibility: a tactile journey from gluten through to coeliac disease. Immunology and Cell Biology. 2024;102(5):10.1111/imcb.12716

Lab research projects

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