The Genomics Laboratory implements advanced genomics technologies, seeking the most effective ways to prepare biological samples for sequencing on our Illumina, MGI, PacBio and Oxford Nanopore platforms.
Members of the Bowden Laboratory are expert in:
Our team enables genomics-based discovery through collaboration. WEHI’s 2021-2025 Genomics Strategic plan provides for the expansion of the institute’s genomics capability in enhanced service, collaboration and R&D. We are focused on institutional provision, extensive collaboration and selected external partnerships centred in Parkville.
Australia, Adelaide University, BSc (Hons), 1991
UK, University of Cambridge PhD, 1997
UK, Oxford University, Dip App Stats, 1998
Co-Chair MACH (Melbourne Academic Centre for Health) Omics Special Advisory Group
1. D Bonsall, T Golubchik, M de Cesare, M Limbada, B Kosloff, G MacIntyre-Cockett, M Hall, C Wymant, MA Ansari, L Abeler-Dorner, A Schaap, A Brown, E Barnes, E Piwowar-Manning, S Eshleman, E Wilson, L Emel, R Hayes, S Fidler, H Ayles, R Bowden, C Fraser, and H team, A comprehensive genomics solution for HIV surveillance and clinical monitoring in low income settings, J. Clin. Microbiol. (2020) PMID: 32669382.
2. AG Hinch, G Zhang, PW Becker, D Moralli, R Hinch, B Davies, R Bowden, and P Donnelly, Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm, Science 363 (6433), eaau8861 (2019) PMID: 30898902.
3. J Kinchen, HH Chen, K Parikh, A Antanaviciute, M Jagielowicz, D Fawkner-Corbett, N Ashley, L Cubitt, E Mellado-Gomez, M Attar, E Sharma, Q Wills, R Bowden, FC Richter, D Ahern, KD Puri, J Henault, F Gervais, H Koohy, and A Simmons, Structural remodeling of the human colonic mesenchyme in inflammatory bowel disease, Cell 175 (2), 372-386.e317 (2018) PMID: 30270042.
4. MA Ansari, V Pedergnana, CLC Ip, A Magri, A Von Delft, D Bonsall, N Chaturvedi, I Bartha, D Smith, G Nicholson, G McVean, A Trebes, P Piazza, J Fellay, G Cooke, GR Foster, E Hudson, J McLauchlan, P Simmonds, R Bowden, P Klenerman, E Barnes, and CCA Spencer, Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus, Nat. Genet. 49, 666-673 (2017) PMID: 28394351.
5. D Bonsall, M Ansari, C Ip, A Trebes, A Brown, P Klenerman, D Buck, P Piazza, E Barnes, and R Bowden, ve-SEQ: Robust, unbiased enrichment for streamlined detection and whole-genome sequencing of HCV and other highly diverse pathogens, F1000Res 4 (1062) (2015) PMID: 27092241.
6. R Bowden, TS Macfie, S Myers, G Hellenthal, E Nerrienet, RE Bontrop, C Freeman, P Donnelly, and NI Mundy, Genomic tools for evolution and conservation in the chimpanzee: Pan troglodytes ellioti Is a genetically distinct population, PLoS Genet 8 (3), e1002504 (2012) PMID: 22396655.
7. T Golubchik, AB Brueggemann, T Street, RE Gertz, Jr., CC Spencer, T Ho, E Giannoulatou, R Link-Gelles, RM Harding, B Beall, TE Peto, MR Moore, P Donnelly, DW Crook, and R Bowden, Pneumococcal genome sequencing tracks a vaccine escape variant formed through a multi-fragment recombination event, Nat. Genet. 44 (3), 352-355 (2012) PMID: 22286217.
8. X Didelot, R Bowden, DJ Wilson, TE Peto, and DW Crook, Transforming clinical microbiology with bacterial genome sequencing, Nat Rev Genet 13 (9), 601-612 (2012) PMID: 22868263.
9. S Myers, R Bowden, A Tumian, RE Bontrop, C Freeman, TS MacFie, G McVean, and P Donnelly, Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination, Science 327 (5967), 876-879 (2010) PMID: 20044541.
10. R Bowden, JP Simas, AJ Davis, and S Efstathiou, Murine gammaherpesvirus 68 encodes tRNA-like sequences which are expressed during latency, J. Gen. Virol. 78 (7), 1675-1687. (1997) PMID: 9225045.
The Cellular Genomics (Projects) team provides single-cell omics, spatial and high-throughput transcriptomics solutions, spanning project design, the application of cutting-edge approaches, and data analysis. Our involvement in your project may range from consultations and transactional services to collaborative projects inside and outside WEHI.
The WEHI Genomics Hub was established in 2013 to operate sequencing platforms for the institute, in conjunction with a genomics ‘hotel’, conceived for scientists to access the specialist facilities and expertise needed to prepare their own samples for analysis.
Since its inception, more than 500 WEHI scientists and external collaborators have benefited from the facility, and the complement of sequencing platforms has grown to include Illumina, PacBio, Oxford Nanopore, and MGI instruments.
We are building on our expertise and track record in genomics innovation to expand the reach of our research and development (R&D) team from cellular genomics into other areas of scientific priority for WEHI, including population health and cohort studies, precision medicine and diagnostics, therapeutic discovery and further advanced genomics and sequencing technologies.
Building on our strengths in applying genomics methods to the efficient, high-throughput, unbiased detection and analysis of pathogen genomes, we are setting up projects in diagnostic methods and studies of host-pathogen interactions, with applications in respiratory infection, population health and infectious disease immunology, and infection in immunosuppressed patients.
We are recruiting a post-doctoral research officer, who will work closely with the lab’s Genomics R&D team.