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About

We are interested in how cytokines such as interleukin-6 help orchestrate development of the haematapoietic system. Cytokines control blood cell differentiation by acting as inter-cellular messengers. However their action needs to be tightly controlled in order to prevent proliferative diseases such as leukemia. The proteins responsible for this control include the SOCS (suppressors of cytokine signaling) family. We are interested in understanding the action of the SOCS proteins and other inhibitory molecules at a molecular level.

Publications

Selected publications from A/Prof Jeff Babon

Lv Y, Qi J, Babon JJ, Cao L, Fan G, Lang J, Zhang J, Mi P, Kobe B, Wang F. Correction: The JAK-STAT pathway: from structural biology to cytokine engineering. Signal Transduction and Targeted Therapy. 2024;9(1):10.1038/s41392-024-01975-1

Lv Y, Qi J, Babon JJ, Cao L, Fan G, Lang J, Zhang J, Mi P, Kobe B, Wang F. The JAK-STAT pathway: from structural biology to cytokine engineering. Signal Transduction and Targeted Therapy. 2024;9(1):10.1038/s41392-024-01934-w

Behrens K, Kauppi M, Viney EM, Kueh AJ, Hyland CD, Willson TA, Salleh L, de Graaf CA, Babon JJ, Herold MJ, Nicola NA, Alexander WS. Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease. Leukemia. 2024;38(6):10.1038/s41375-024-02219-5

Lv Y, Mi P, Babon JJ, Fan G, Qi J, Cao L, Lang J, Zhang J, Wang F, Kobe B. Small molecule drug discovery targeting the JAK-STAT pathway. Pharmacological Research. 2024;204:10.1016/j.phrs.2024.107217

Zhang Y, Morris R, Brown GJ, Lorenzo AMD, Meng X, Kershaw NJ, Kiridena P, Burgio G, Gross S, Cappello JY, Shen Q, Wang H, Turnbull C, Lea-Henry T, Stanley M, Yu Z, Ballard FD, Chuah A, Lee JC, Hatch A-M, Enders A, Masters SL, Headley AP, Trnka P, Mallon D, Fletcher JT, Walters GD, Šestan M, Jelušić M, Cook MC, Athanasopoulos V, Fulcher DA, Babon JJ, Vinuesa CG, Ellyard JI. Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity. Journal of Experimental Medicine. 2024;221(4):10.1084/jem.20221080

Sarson-Lawrence KTG, Hardy JM, Iaria J, Stockwell D, Behrens K, Saiyed T, Tan C, Jebeli L, Scott NE, Dite TA, Nicola NA, Leis AP, Babon JJ, Kershaw NJ. Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin. Nature Communications. 2024;15(1):10.1038/s41467-024-45356-2

Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang J-G, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NPD, Linossi EM, Burns CJ, Carotta S, Gray DHD, Seillet C, Hutchinson DS, Belz GT, Webb AI, Alexander WS, Li SS, Bullock AN, Babon JJ, Smyth MJ, Nicholson SE, Huntington ND. Author Correction: CIS is a potent checkpoint in NK cell–mediated tumor immunity. Nature Immunology. 2024;25(2):10.1038/s41590-023-01714-8

Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SS, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE. Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications. 2023;14(1):10.1038/s41467-023-42706-4

Sarson-Lawrence KTG, Hardy JM, Iaria J, Saiyed T, Leis AP, Babon JJ, Kershaw NJ. Structural studies of the thrombopoietin–thrombopoietin receptor signalling complex. Acta Crystallographica Section A: Foundations and advances. 2023;79(a2):10.1107/s2053273323086734

Liang S, Tran E, Du X, Dong J, Sudholz H, Chen H, Qu Z, Huntington ND, Babon JJ, Kershaw NJ, Zhang Z-Y, Baell JB, Wiede F, Tiganis T. A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity. Nature Communications. 2023;14(1):10.1038/s41467-023-40170-8

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