The Majewski laboratory uses genomic approaches to identify germline and somatic alterations that drive cancer biology.

Ian completed a PhD in genetics at WEHI in 2008. He moved overseas to postdoc with René Bernards at the Netherlands Cancer Institute (NKI), where he studied genetic alterations in breast, colon and lung cancer, before returning to Melbourne to start his own laboratory.

Ian’s research has provided new insight into how DNA repair pathways modulate cancer risk. He is particularly interested in how different forms of DNA damage shape the earliest stages of cancer.


Selected publications from A/Prof Ian Majewski

Fang et al., Ganciclovir-induced mutations are present in a diverse spectrum of post-transplant malignancies. Genome Medicine (2022) PMID: 36316687

Palles et al., Germline MBD4 deficiency causes a multi-tumor predisposition syndrome. American Journal of Human Genetics (2022). PMID: 35460607

Sanders et al., MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML. Blood (2018). PMID: 30049810

DiNardo et al., Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML. Blood (2020). PMID: 31932844

Majewski et al., PIK3CA Mutations Are Associated With Decreased Benefit to Neoadjuvant Human Epidermal Growth Factor Receptor 2-Targeted Therapies in Breast Cancer. Journal of Clinical Oncology (2015). PMID: 25559818

Majewski et al., Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing. The Journal of Pathology 230, 270 (2013). PMID: 23661334

Majewski et al., An alpha-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. The Journal of Pathology 229, 621 (2013). PMID: 23208944

Majewski & Bernards, Taming the dragon: genomic biomarkers to individualize the treatment of cancer. Nature Medicine. 2011; 17, 304 (2011). PMID: 21386834

Lab research projects

Interested in supporting our research?

Your support will help WEHI’s researchers make discoveries and find treatments to ensure healthier, longer lives for you and your loved ones.

Contact our friendly team to find out how you can help.