Many mechanisms have evolved to ensure that the immune system does not attack our own tissues; a property referred to as immunological tolerance. The main goal of our team is to understand how to modify tolerance mechanisms to create new ways to treat cancer and autoimmune diseases.

A major project focuses on understanding how defects in cell death and immune homeostasis engender disease. We employ novel pre-clinical models, high dimensional cytometry and advanced imaging approaches to address how these processes shape the development and function of T cells in health and disease.


Selected publications from Prof Daniel Gray

Weeden, C. E., Gayevskiy, V., Marceaux, C., …, Mackay L., Speed, T. P., Gray, D. H. D.*., Asselin-Labat ML*. (*equal contribution) (2023) Early immune pressure imposed by tissue resident memory T cells sculpts tumour evolution in non-small cell lung cancer. Cancer Cell(accepted)http://dx.doi.org/10.2139/ssrn.4187262

Policheni AN, Teh CE, Robbins AK, Tuzlak S, Strasser A, Gray DHD. PD-1 cooperates with AIRE-mediated tolerance to prevent lethal autoimmune disease. Proc Natl Acad Sci U S A Apr 12;119(15):e2120149119. doi: 10.1073/pnas.212019119. Epub 2022 Apr 8. PMID: 35394861

Teh CE*, Preston SP*, Robbins AK, Stutz MD, … Kallies A, Strasser A, Pellegrini M*, Gray DHD* (* equal contribution). Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage. Sci Immunol. 2022 Mar 25;7(69):eabn8041. doi: 10.1126/sciimmunol.abn8041. Epub 2022 Mar 25 PMID: 35333545

Melanie Heinlein, Luke C Gandolfo, Kelin Zhao, Charis E Teh, Nghi Nguyen, Jonathan B Baell, Yael Goldfarb, Jakub Abramson, Johannes Wichmann, Anne K Voss, Andreas Strasser, Gordon K Smyth, Tim Thomas, Daniel H D Gray. The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance. Sci Immunol. 2022 Jan 21;7(67):eabb6032. doi: 10.1126/sciimmunol.abb6032. Epub 2022 Jan 21. PMID: 35061506

Jain R., Zhao K., Sheridan J.M., Heinlein M., Kupresanin F., Abeysekera W., Hall C., Rickard J., Bouillet P., Walczak H., Strasser A., Silke J. and Gray D.H.D. Dual roles for LUBAC signaling in thymic epithelial cell development and survival. Cell Death and Differentiation, Aug 11 doi 10.1038/s41418-021-00850-8. PMID:34381167

Teh, C.E., Gong, J.N., Segal, D., Tan, T., Vandenberg, C.J., Fedele, P.L., Low, M.S.Y., Grigoriadis, G., Harrison, S.J., Strasser, A., Roberts, A.W., Huang, D.C.S., Nolan, G.P.*,#, Gray, D.H.D.*,#, and Ko, M.E*. Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells. (* co-senior author; # corresponding authors) Cell Death and Differentiation. 2020 Jul;27(7):2217-2233. doi: 10.1038/s41418-020-0498-z. PMID:31988495

Jain, R., Sheridan, J.M., Policheni, A., Heinlein, M., Gandolfo, L.C., Dewson, G., Smyth, G.K., Sansom, S.N., Fu, N.Y., Visvader, J.E., Hollander, G.A., Strasser, A., and Gray, D.H.D. A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice. Blood 2017, Dec 7;130(23):2504-2515. Doi: 10.1182/blood-2017-03-771576. PMID:28972012

Teh, C.E., Lalaoui, N., Jain, R., Policheni, A.N., Heinlein, M., Alvarez-Diaz, S., Sheridan, J.M., Rieser, E., Deuser, S., Darding, M., Koay, H.-F., Hu, Y., Kupresanin, F., O’Reilly, L.A., Godfrey, D.I., Smyth, G.K., Bouillet, P., Strasser, A., Walczak, H., Silke, J., and Gray, D.H.D. Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis. Nature Communications 2016; 7: 13353. Doi: 10.1038/ncomms13353. PMID:27857075

Liston, A., and Gray, D.H.D. Homeostatic control of regulatory T cell diversity. Nature Reviews Immunology 2014; 14(3): 154-65. PMID: 24481337

Pierson, W., Cauwe, B., Policheni, A., … Weaver, C.T., Dooley, J., Gray, D.H.D.*, and Liston, A.* (joint senior/corresponding authors) Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3(+) regulatory T cells. Nature Immunology 2013; 14(9): 959-65. PMID:23852275

Lab research projects

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