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Technologies
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About

Many mechanisms have evolved to ensure that the immune system does not attack our own tissues; a property referred to as immunological tolerance. The main goal of our team is to understand how to modify tolerance mechanisms to create new ways to treat cancer and autoimmune diseases.

A major project focuses on understanding how defects in cell death and immune homeostasis engender disease. We employ novel pre-clinical models, high dimensional cytometry and advanced imaging approaches to address how these processes shape the development and function of T cells in health and disease.

Publications

Selected publications from Prof Daniel Gray

Luo M-X, Tan T, Trussart M, Poch A, Nguyen M-HT, Speed TP, Hicks DG, Bandala-Sanchez E, Peng H, Chappaz S, Slade C, Utzschneider DT, Koldej RM, Ritchie D, Strasser A, Thijssen R, Ritchie ME, Tam CSL, Lindeman GJ, Huang DCS, Lew TE, Anderson MA, Roberts AW, Teh CE, Gray DHD. Venetoclax Dose Escalation Rapidly Activates a BAFF/BCL-2 Survival Axis in Chronic Lymphocytic Leukemia. Blood. 2024;:10.1182/blood.2024024341

Kousa AI, Jahn L, Zhao K, Flores AE, Acenas D, Lederer E, Argyropoulos KV, Lemarquis AL, Granadier D, Cooper K, D’Andrea M, Sheridan JM, Tsai J, Sikkema L, Lazrak A, Nichols K, Lee N, Ghale R, Malard F, Andrlova H, Velardi E, Youssef S, Burgos da Silva M, Docampo M, Sharma R, Mazutis L, Wimmer VC, Rogers KL, DeWolf S, Gipson B, Gomes ALC, Setty M, Pe’er D, Hale L, Manley NR, Gray DHD, van den Brink MRM, Dudakov JA. Age-related epithelial defects limit thymic function and regeneration. Nature Immunology. 2024;25(9):10.1038/s41590-024-01915-9

Biemond M, Vremec D, Gray DH, Hodgkin PD, Heinzel S. Programmed death receptor 1 (PD‐1) ligand Fc fusion proteins reduce T‐cell proliferation in vitro independently of PD‐1. Immunology and Cell Biology. 2024;102(2):10.1111/imcb.12714

Joyce R, Pascual R, Heitink L, Capaldo BD, Vaillant F, Christie M, Tsai M, Surgenor E, Anttila CJA, Rajasekhar P, Jackling FC, Trussart M, Milevskiy MJG, Song X, Li M, Teh CE, Gray DHD, Smyth GK, Chen Y, Lindeman GJ, Visvader JE. Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers. Nature Cell Biology. 2024;26(1):10.1038/s41556-023-01315-5

Chua CC, Anstee N, Flensburg C, Teh C, Ivey A, Amin N, Thijssen R, Bohlander SK, Kakadia PM, Xu Z, Fong CY, Ting S, Loo S, Tiong IS, Gray D, Fleming S, Davidson N, Roberts AW, Majewski I, Wei AH, Brown FC. Venetoclax Has Potent Efficacy in NPM1 mutated AML with Acquired Resistance Associated with Either Perturbed Pro-Survival Signalling or NPM1 wild-Type Populations. Blood. 2023;142(Supplement 1):10.1182/blood-2023-185321

Tiong IS, Nguyen T, Teh C, Chua CC, Ftouni S, Lew TE, Brown FC, Moujalled D, Muttiah C, Gray D, Anderson MA, Thompson PA, Tam CS, Seymour JF, Dawson S-J, Wei AH, Lindeman G, Blombery P. BAX Mutated Clonal Hematopoiesis Arises Following Treatment with the BCL2 Inhibitor Class of Therapeutics across a Range of Hematological and Non-Hematological Neoplasms. Blood. 2023;142(Supplement 1):10.1182/blood-2023-180386

Xu C, Li S, Fulford TS, Christo SN, Mackay LK, Gray DH, Uldrich AP, Pellicci DG, I Godfrey D, Koay H-F. Expansion of MAIT cells in the combined absence of NKT and γδ-T cells. Mucosal Immunology. 2023;16(4):10.1016/j.mucimm.2023.05.003

Teh CE, Peng H, Luo M-X, Tan T, Trussart M, Howson LJ, Chua CC, Muttiah C, Brown F, Ritchie ME, Wei AH, Roberts AW, Bryant VL, Anderson MA, Lindeman GJ, Huang DCS, Thijssen R, Gray DHD. Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells. Blood Advances. 2023;7(12):10.1182/bloodadvances.2022008221

Abdulla HD, Alserihi R, Flensburg C, Abeysekera W, Luo M-X, Gray DHD, Liu X, Smyth GK, Alexander WS, Majewski IJ, McCormack MP. Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition. Journal of Experimental Medicine. 2023;220(6):10.1084/jem.20212383

Weeden CE, Gayevskiy V, Marceaux C, Batey D, Tan T, Yokote K, Ribera NT, Clatch A, Christo S, Teh CE, Mitchell AJ, Trussart M, Rankin L, Obers A, McDonald JA, Sutherland KD, Sharma VJ, Starkey G, D’Costa R, Antippa P, Leong T, Steinfort D, Irving L, Swanton C, Gordon CL, Mackay LK, Speed TP, Gray DHD, Asselin-Labat M-L. Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer. Cancer Cell. 2023;41(5):10.1016/j.ccell.2023.03.019

Lab research projects

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