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About

The main focus of our laboratory is to define how signal transduction by cytokines can modulate tissue homeostasis, and to understand how deregulation of these signalling pathways can promote numerous diseases, including cancer.

We use cell biology, molecular biology and structural biology techniques to understand how cytokines enable cancers to grow, metastasise and develop resistance to current treatments.

Our goal is to use the knowledge gained to facilitate the development of new therapeutic opportunities.

Publications

Selected publications from A/Prof Tracy Putoczki

Pires S, Yang W, Louis C, Tran N, Hassan-Zahraee M, Ye Z, Hung KE, Hyde C, Lukin DJ, Scherl EJ, Targan S, Putoczki T, Wicks I, Longman RS. 220 TL1A DRIVES ILC-MEDIATED GRANULOPOIESIS AND COLITIS ASSOCIATED CANCER. Gastroenterology. 2024;166(5):10.1016/s0016-5085(24)00600-0

Dagley LF, Yousef J, Preaudet A, Loving A, Webb AI, Ernst M, Putoczki TL. Identification of Serum Biomarkers to Monitor Therapeutic Response in Intestinal-Type Gastric Cancer. International Journal of Molecular Sciences. 2024;25(6):10.3390/ijms25063129

Low RRJ, Fung KY, Dagley LF, Yousef J, Emery-Corbin SJ, Putoczki TL. Unbiased Quantitative Proteomics of Organoid Models of Pancreatic Cancer. Methods in Molecular Biology. 2024;2823:10.1007/978-1-0716-3922-1_6

Anand S, Nedeva C, Chitti SV, Fonseka P, Kang T, Gangoda L, Tabassum NI, Abdirahman S, Arumugam TV, Putoczki TL, Kumar S, Mathivanan S. The E3 ubiquitin ligase NEDD4 regulates chemoresistance to 5-fluorouracil in colorectal cancer cells by altering JNK signalling. Cell Death & Disease. 2023;14(12):10.1038/s41419-023-06349-z

Metcalfe RD, Hanssen E, Fung KY, Aizel K, Kosasih CC, Zlatic CO, Doughty L, Morton CJ, Leis AP, Parker MW, Gooley PR, Putoczki TL, Griffin MDW. Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Nature Communications. 2023;14(1):10.1038/s41467-023-42754-w

Lee B, Yousef J, Fung KY, Emery-Corbin S, Dagley L, Baldoni P, Smyth G, Gibbs P, Putoczki T. 174P Unlocking the potential of blood-based biomarkers in pancreatic cancer for early detection and therapeutic screening. Annals of Oncology. 2023;34:10.1016/j.annonc.2023.10.309

Low RRJ, Fung KY, Gao H, Preaudet A, Dagley LF, Yousef J, Lee B, Emery-Corbin SJ, Nguyen PM, Larsen RH, Kershaw NJ, Burgess AW, Gibbs P, Hollande F, Griffin MDW, Grimmond SM, Putoczki TL. Correction to: S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer. Cell Death & Differentiation. 2023;30(5):10.1038/s41418-023-01151-y

Low RRJ, Fung KY, Gao H, Preaudet A, Dagley LF, Yousef J, Lee B, Emery-Corbin SJ, Nguyen PM, Larsen RH, Kershaw NJ, Burgess AW, Gibbs P, Hollande F, Griffin MDW, Grimmond SM, Putoczki TL. S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer. Cell Death & Differentiation. 2023;30(5):10.1038/s41418-023-01126-z

Stuart SF, Bezawork-Geleta A, Areeb Z, Gomez J, Tsui V, Zulkifli A, Paradiso L, Jones J, Nguyen HPT, Putoczki TL, Licciardi PV, Kannourakis G, Morokoff AP, Achuthan AA, Luwor RB. The Interleukin-11/IL-11 Receptor Promotes Glioblastoma Survival and Invasion under Glucose-Starved Conditions through Enhanced Glutaminolysis. International Journal of Molecular Sciences. 2023;24(4):10.3390/ijms24043356

Preaudet A, Fung KY, Putoczki TL. Confocal Endomicroscopy Monitoring of Tumor Formation. Methods in Molecular Biology. 2023;2691:10.1007/978-1-0716-3331-1_20

Lab research projects

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