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- A new target in cancer immunotherapy
- Domain-specific BET bromodomain inhibitors for cancer
- Targeting BFL-1 for the treatment of cancer
- Jointly targeting IGF-1R and IR in cancer
- Targeting necroptosis for the treatment of inflammatory diseases
- Soluble CD52 as a therapeutic for inflammatory disease
- TBK inhibitors to treat rheumatoid arthritis
- A novel therapeutic to treat malaria
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- Associate Professor Aaron Jex
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- Catherine Parker
- Dr Andrew Webb
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- Dr Colin Ward
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- Dr Emma Josefsson
- Dr Ethan Goddard-Borger
- Dr Grant Dewson
- Dr Gwo Yaw Ho
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- Dr Ian Majewski
- Dr Ian Street
- Dr Jacqui Gulbis
- Dr James Murphy
- Dr James Vince
- Dr Jason Tye-Din
- Dr Jeff Babon
- Dr Joanna Groom
- Dr John Wentworth
- Dr Julian Clark
- Dr Julie Mercer
- Dr Justin Boddey
- Dr Kate Sutherland
- Dr Kelly Rogers
- Dr Ken Pang
- Dr Leanne Robinson
- Dr Leigh Coultas
- Dr Marco Herold
- Dr Marie-Liesse Asselin-Labat
- Dr Mary Ann Anderson
- Dr Maryam Rashidi
- Dr Matthew Call
- Dr Matthew Ritchie
- Dr Melissa Call
- Dr Melissa Davis
- Dr Michael Low
- Dr Misty Jenkins
- Dr Peter Czabotar
- Dr Philippe Bouillet
- Dr Priscilla Auyeung
- Dr Rhys Allan
- Dr Ruth Kluck
- Dr Samar Ojaimi
- Dr Samir Taoudi
- Dr Sandra Nicholson
- Dr Seth Masters
- Dr Shalin Naik
- Dr Shereen Oon
- Dr Simon Chatfield
- Dr Stephen Wilcox
- Dr Tracy Putoczki
- Dr Wai-Hong Tham
- Dr Wei Shi
- Guillaume Lessene
- Helene Martin
- Isabelle Lucet
- Keely Bumsted-O'Brien
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- Ms Carolyn MacDonald
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- Ms Wendy Hertan
- Nicholas Huntington
- Professor Alan Cowman
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- Professor Andrew Lew
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- Professor Benjamin Kile
- Professor David Huang
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- Professor Doug Hilton
- Professor Gabrielle Belz
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- Professor Nicos Nicola
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- Professor Stephen Nutt
- Professor Suzanne Cory
- Professor Terry Speed
- Professor Tony Burgess
- Professor Warren Alexander
- Student research projects
- A novel role for Mind Bomb-2 (MIB2) in cell death and inflammation
- A systems approach to tackle immune complexity
- Antigenic diversity of malaria parasites: towards more effective malaria vaccines
- Apoptotic caspases, cell death, infection, inflammation and cancer
- Biological sequence analysis and genomic variant discovery
- Cell biology of killer CAR-T cells: improving immunotherapy
- Cell death, homeostasis and senescence in the immune system
- Cell-specific gene expression in autistic and schizophrenic human brains
- Chemical probing to identify effectors of necroptotic cell death
- Choreography of cell death by necroptosis
- Combining imaging and mathematics to understand immunity and cancer
- Computational comparative genomics of the scabies mite
- Computational systems biology of Wnt/cell adhesion signalling in colon cancer
- Controlling apoptotic cell death in cancer
- Cross-talk between cell death and inflammatory signalling pathways
- Cytokine control of blood cell function in health and disease
- Death-eating: how cell death pathways regulate autophagy
- Deciphering mechanisms of thrombocytopenia (low platelet count) in blood cancers
- Defining the function of the interleukin-11 signalling complex
- Determining the geographic origin of pathogenic human mutations
- Determining the migration signals that lead to protective immune responses
- Determining the requirements for T cell memory
- Developing and testing new drugs to treat inflammatory diseases
- Developing intracellular antibodies to trigger apoptotic cell death
- Discovery and analysis of autoimmune regulators
- Drug targets and compounds that block growth of malaria parasites
- Dynamic discovery of innate immunity through imaging and genomics
- Emerging role of pseudokinases in cancer
- Epigenetic targeting of plasmacytoid dendritic cells to treat lupus
- Finding non-standard causes of monogenic disorders
- Function of proteins involved in invasion of erythrocytes by malaria parasites
- Home renovations: understanding how Toxoplasma redecorates its host cell
- How TNF signalling pathways govern T cell development and homeostasis
- How do killer cells detach from target cells?
- Identification of RNA biomarkers in autism
- Identification of malaria parasite entry receptors
- Identification of the key regulators of plasma cell biology
- Identifying new epigenetic approaches to treat autoimmune disease
- Identifying the functional basis of recent selective sweeps in the malaria genome
- Immune evasion strategies of malaria parasites
- Immune mechanisms of vascular disease
- Investigating breast cancer development in BRCA1/2 mutation carriers
- Investigating mechanisms of cell death and survival using zebrafish
- Investigating mechanisms of innate immune activation
- Investigating the biology of lung cancer
- Let me in! How Toxoplasma invades human cells
- Long-read sequencing for transcriptome and epigenome analysis
- Mechanics of T cell receptor activation
- Mechanistic and functional drivers of cancer neochromosomes
- Membrane transport studies
- Molecular genetics of megakaryocytic leukaemia
- New therapeutics for metastatic colorectal and pancreatic cancers
- Next-generation mucolytics to treat lung diseases
- No sex please, we’re inhibited: searching for drugs to prevent malaria transmission
- Novel real-time, quantitative imaging approaches for studying malaria
- Probing the control of lineage fate and function in the blood forming system
- Protein export to hijack human cells during liver-stage malaria
- Quantitation of human T cell expansion in health and disease
- Reconstructing the immune response: from molecules to cells to systems
- Regulation of cytokine signalling
- Regulation of normal and cancerous intestinal stem cell dynamics by PHLDA1
- Role of cell death in blood vessel growth and regression
- Single cell RNA-seq for biomarker discovery and immune status assessment
- Statistical bioinformatic analyses of RNA-seq and ChIP-seq data
- Stopping the rogue immune cells that attack pancreatic islets in diabetes
- Structural and biochemical studies on Notch signal transduction
- Structural and functional analysis of malaria invasion
- Structural biology and drug discovery for Bcl-2 family proteins
- Structural studies of human voltage dependent anion channel 2
- Structural studies of invasion processes during malaria infection
- Structural studies of the Plasmodium and Toxoplasma tight-junction complex
- Structure and function of the enigmatic cell death protein Bok
- Structure function studies of the Pyrin inflammasome
- Student research opportunity
- Systems approach to understand adipose inflammation and type 2 diabetes
- TNF-induced inflammation, inflammatory bowel disease and colon cancer
- Target identification of potent antimalarial agents
- The importance of glycosylation in malaria infection of the mosquito and human host
- The molecular basis of host cell traversal by malaria parasites
- The quantitative impact of immune checkpoints on T cell proliferation
- Towards a molecular description of plasma cell diversity
- Tracking the spread of malaria in the Asia Pacific region
- Transmembrane control of type I cytokine receptor activation
- Tumour heterogeneity and evolution
- Understanding mitochondrial pore formation during apoptotic cell death
- Understanding the ATPase domain of the epigenetic regulator, Smchd1
- Understanding the development of humoral immunity to malaria
- Understanding the mechanisms of drug resistance in acute myeloid leukaemia
- Unraveling excystation in Giardia lablia
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- Renewed support for HIV eradication project
- Supporting research into better treatments for colon cancer
- Taking a single cell focus with the DROP-seq
- Working towards personalised treatments for cancer
International Women's Day
From the earliest days of the institute, women have played pivotal roles in the organisation's success.
To celebrate International Women's Day, we profiled a number of these impressive #WEHIwomen who have produced breakthrough research, driven strategic growth, and helped improve health outcomes.
Kelan is pushing research boundaries in her work with genetics. Her research could help prevent an incurable form of muscular dystrophy. Kelan contributes to our engagement programs aimed at increasing our profile in the Australian-Chinese community as well as Victorian secondary school students.
There is a lot of big data in science, using computational techniques Melissa is studying how networks of molecular interactions process biological information. She is seeking to understand the behaviour of cells in normal and cancerous tissues.
Isabella uses flow cytometery to gain understanding of how epigenetic drugs influence the immune response. She has also contributed to our gender equity initiatives and provided support to our CareerTracker interns.
Working with animals in research is not easy, but it’s incredibly valuable. Gill managed the animal facilities in Kew and always put the welfare of the animal first.
Discovering how ‘good’ T cells supress ‘bad’ T cells has led Esther to discover a method that could revolutionise testing and treatment for type 1 diabetes.
Helene began at the Institute as a research scientist, before moving into management and operational roles. Her work has included liaising between our scientists and corporate groups to coordinate delivery of high-quality services and facilities.
Judith’s contributions to our Consumer Advisory Panel have enabled our researchers to enhance connections with community experiences of disease and expectations of scientific outcomes.
Assisting in the development and delivery of the Institute’s vision for the future, Catherine’s experience in strategic planning and public policy facilitates improvements in our governance and administrative processes.
Misty investigates white blood cells, the ‘serial killers’ of the immune system. Her work in science and the community has been recognised here and internationally, she is an advocate for women in STEMM and encourages Aboriginal students into the scientific field.
Rhiannon has been living, breathing and reading science. In 2016, Rhiannon achieved her Honours in the same year as reading 366 scientific papers in 366 days (2016 being a leap year).
Often called the face of the Institute, Rosie uses her extensive knowledge and experience of the organisation to help our staff, students, visitors and supporters every day.
Wai-Hong is deciphering interactions between parasite and human proteins to discover new ways to prevent malarial blood stage infection.
Before accounting and leadership positions in corporate business, Jane completed a double degree in biochemistry and physiology. Her path back to research has been deeply personal, providing a complex perspective on the challenges facing science and the people it effects.
While completing her PhD in Jerusalem, Emanuela discovered inspiration on the other side of the world, leading to a potential vaccine.
“Actuated by the desire to do something noble for the country in which her husband had met with a substantial reward for his labor,” in 1912 Eliza founded the Walter and Eliza Hall Trust, which led to the establishment of the Walter and Eliza Hall Institute for Research in Pathology and Medicine.
Understanding the combination of factors in the environment, human host and mosquito vector helps malaria research. Alyssa collaborates closely with researchers conducting malaria control programs in the Asia Pacific to develop control and elimination strategies.
One of the first three staff members of the institute, Fannie was a bacteriologist in WWI and contributed to ground-breaking work in combating dysentery.
A clinician/PhD student, Shereen’s research into lupus aims to understand the disease and explore treatment opportunities.
Malaria field work in PNG is precisely how Leanne likes to undertake research. Her work has involved collecting blood samples from hundreds of school children, studying the natural immune responses of children in malarial zones.
In the 1970s, Ora’s expertise in DNA sequencing placed her at the forefront of molecular biology. Her most significant discovery showed how a specific gene impacts the spread of cancer.
Lynn has a reputation as a mentor for young scientists and a champion of the next generation of women coming into the laboratory.
Emma’s research into understanding how platelets are formed has provided insights into potential treatments for patients undergoing chemotherapy.
A pioneer in scientific mouse breeding, Margaret dedicated 50 years to the institute, making significant contributions to immunology research, and was central in the successful management of the organisation.
Susan has been a good friend to the institute over many years, her fundraising efforts have greatly assisted in our work to understand how type 1 diabetes develops and in finding treatments for this life changing disease.
Jane has received awards for her breast cancer research from across the world, but it’s the search for the key to improve disease outcomes that truly inspires her.
Keeping one step ahead of cancer is Clare’s motivational drive. Her ambition is to apply insights fast emerging from blood models to understand solid tumours.
Suzanne is an eminent molecular biologist with a record of significant achievements in immunology and cancer research. In her role as institute director, Suzanne embraced new scientific disciplines and changed the face of the organization, securing funding for the $185 million Parkville redevelopment.
Jacqui’s studies into cellular machinery at a molecular level aims to understand both how proteins transport molecules in and out of cells and how this function is regulated.
Over two decades, Margaret managed our operational requirements, from official visits from the Duke of Edinburgh and Margaret Thatcher to approval for our first PC3 containment lab.
Discoveries need donors and scientists; Susanne drives our award-winning philanthropic engagement program, connecting supporters with researchers.
Working in a culture of collaboration and cooperation, Melissa’s interest in understanding the activation of immune cells has led to exploring cell communication pathways for cancer, infection and immune disorder treatment opportunities.
As a medical researcher, Tracy clearly sees “we donate our lives and our brains to what we do, and hopefully by the time we get to the end of our careers we’ve discovered something exciting … something that patients are receiving, that is improving their lives”.
Anne is and always has been obsessed with T cells, her expertise contributed to the cloning of the first recombinant CSF. Today, her role as CEO of the NHMRC means she oversees the national government research funded programs.
Hailed a martyr to science, Dora’s contributions to scientific outcomes include journal articles on influenza, myxomatosis and the herpes simplex virus, as well as significant insights into scrub typhus, the disease that ultimately killed her.
Driving strategic leadership, Sam implements best practice and continuous improvement to ensure our research and business practices continue to place us as leaders in our field.
Heather’s academic and professional success gained her a public profile, including her collaboration with UK scientists to pioneer the use of electron microscopy to study influenza.
Marnie was 27 when she discovered a ‘new’ gene; her work has progressed to help uncover genetic causes of problems including late miscarriage and muscular dystrophy.
Working closely with clinician researchers to examine genetic disorders, Melanie develops new methods to analyse complex data, producing software that is freely available to others and thereby aiding many research fields.
After years of painstaking investigation, Anne discovered a human protein that has had a huge impact on our understanding of cell biology. This knowledge has led to potentially powerful cancer treatments.
Sara’s studies into mosquito biology and parasitology have led to managing and developing our insectary. Her work enriches our malaria research program, working with scientists here and globally.
An enduring friendship led Katherine to raise over $5000 to support our breast cancer research through swimming, bicycling and running.
From a background in molecular endocrinology research and working with the NHMRC, Julie leads our reputable Research Grants Office.