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- A multi-pronged approach to targeting myeloproliferative neoplasms
- A new paradigm of machine learning-based structural variant detection
- A whole lot of junk or a treasure trove of discovery?
- Advanced imaging interrogation of pathogen induced NETosis
- Analysing the metabolic interactions in brain cancer
- Atopic dermatitis causes and treatments
- Boosting the efficacy of immunotherapy in lung cancer
- Building a cell history recorder using synthetic biology for longitudinal patient monitoring
- Characterisation of malaria parasite proteins exported into infected liver cells
- Deciphering the heterogeneity of the tissue microenvironment by multiplexed 3D imaging
- Defining the mechanisms of thymic involution and regeneration
- Delineating the molecular and cellular origins of liver cancer to identify therapeutic targets
- Developing computational methods for spatial transcriptomics data
- Developing drugs to block malaria transmission
- Developing models for prevention of hereditary ovarian cancer
- Developing statistical frameworks for analysing next generation sequencing data
- Development and mechanism of action of novel antimalarials
- Development of novel RNA sequencing protocols for gene expression analysis
- Discoveries in red blood cell production and function
- Discovering epigenetic silencing mechanisms in female stem cells
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Dissecting mechanisms of cytokine signalling
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- Epigenetic biomarkers of tuberculosis infection
- Epigenetics – genome wide multiplexed single-cell CUT&Tag assay development
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Exploiting the cell death pathway to fight Schistosomiasis
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- How do nutrition interventions and interruption of malaria infection influence development of immunity in sub-Saharan African children?
- Human lung protective immunity to tuberculosis
- Improving therapy in glioblastoma multiforme by activating complimentary programmed cell death pathways
- Innovating novel diagnostic tools for infectious disease control
- Integrative analysis of single cell RNAseq and ATAC-seq data
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigation of a novel cell death protein
- Malaria: going bananas for sex
- Mapping spatial variation in gene and transcript expression across tissues
- Mechanisms of Wnt secretion and transport
- Multi-modal computational investigation of single-cell communication in metastatic cancer
- Nanoparticle delivery of antibody mRNA into cells to treat liver diseases
- Naturally acquired immune response to malaria parasites
- Organoid-based discovery of new drug combinations for bowel cancer
- Organoid-based precision medicine approaches for oral cancer
- Removal of tissue contaminations from RNA-seq data
- Reversing antimalarial resistance in human malaria parasites
- Role of glycosylation in malaria parasite infection of liver cells, red blood cells and mosquitoes
- Screening for novel genetic causes of primary immunodeficiency
- Single-cell ATAC CRISPR screening – Illuminate chromatin accessibility changes in genome wide CRISPR screens
- Spatial single-cell CRISPR screening – All in one screen: Where? Who? What?
- Statistical analysis of single-cell multi-omics data
- Structural and functional analysis of epigenetic multi-protein complexes in genome regulation
- Structural basing for Wnt acylation
- Structure, dynamics and impact of extra-chromosomal DNA in cancer
- Targeted deletion of disease-causing T cells
- Targeting cell death pathways in tissue Tregs to treat inflammatory diseases
- The cellular and molecular calculation of life and death in lymphocyte regulation
- The role of hypoxia in cell death and inflammation
- The role of ribosylation in co-ordinating cell death and inflammation
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding cellular-cross talk within a tumour microenvironment
- Understanding the genetics of neutrophil maturation
- Understanding the roles of E3 ubiquitin ligases in health and disease
- Unveiling the heterogeneity of small cell lung cancer
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to understand malaria invasion and transmission
- Using structural biology to understand programmed cell death
- Validation and application of serological markers of previous exposure to malaria
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Melissa Davis - Publications
Researcher:
Selected publications
- Detchokul S, Elangovan A, Crampin EJ, Davis MJ* and Frauman AG* (*Co-senior authors). Network analysis of an in vitro model of androgen-resistance in prostate cancer. BMC Cancer. 2015 Nov 10; 15:883. PMID: 26553226
- Cursors J, Leuchowius KJ, Waltham M, Thomaskovic-Crook E, Foroutan M, Bracken CP, Redfern A, Crampin EJ, Street I*, Davis MJ*, and Thompson EW* (*Co-senior authors). Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines. Cell Com. Sig. 2015 May 15; 13:26. PMID: 25975820
- Budden DM, Hurley DG, Cursors J, Markham JF, Davis MJ and Crampin EJ. Predicting expression: the complementary power of histone modification and transcription factor binding data. Epigenetics Chromatin. 2014 Nov 24; 7(1):36. PMID: 25489339
- Genovese LA, Ng CG, Davis MJ, Remke M, Taylor MD, Adams DJ, Rust AG, Ward JM, Ban KH, Jenkins NA, Copeland NG, Wainwright BJ. Sleeping Beauty mutagenesis in a mouse medulloblastoma model identifies networks that discriminate between human molecular subgroups. PNAS. 2013 Nov 12; 110(46):E4325-34. PMID: 24167280
- Davis MJ and Ragan MA. Understanding cellular function and disease with comparative pathway analysis. Genome Med. 2013 Jul 26; 5(7):64. PMID: 23889971
- Collins BM, Davis MJ, Hancock JF and Parton RG. Structure-based reassessment of the cave-in signalling model: do caveolae regulate signalling through caveolin-protein interactions? Dev Cell. 2012 Jul 17; 23(1):11-20. PMID: 22814599
- Davis MJ, Shin CJ, Jing N and Ragan MA. Rewiring the dynamic interactome. Mol Biosyst. 2012 Aug; 8(8):2054-66. PMID: 22729145
- Davis KM, Hanson KA, Clark F, Zhang F, Kasukawa T, Kai C, Kawai J, Carninci P and Teasdale RD. Differential use of signal peptides and membrane domains is a common occurrence in the protein output of transcriptional units. PLoS Genetics. 2006 Apr; 2(4):e46. PMID: 16683029
- Carninci P, (Davis MJ, 18th of 195 authors) and Hayashizaki Y. The Transcriptional landscape of the mammalian genome. Science. Sep2; 309(5740):1559-63. PMID: 16141072
- Kanapin A, Batalov S, Davis MJ, Gough J, Grimmond S, Kawaji H, Margrane M, Matsuda H, Schonbach C, Teasdale RD, RIKEN GER Group and Yuan Z. Mouse Proteome Analysis. Genome Res. 2003 Jun; 13(6B):1335-44. PMID: 12819131
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