Ubiquitin, a small but mighty protein, is present in nearly all human tissues and plays a crucial role in controlling cellular processes. However, when Ub signalling goes awry, it has been associated with various diseases.
The Feltham laboratory is a place where cutting-edge research is being conducted to unravel the mysteries of how Ub signalling becomes disrupted.
In the Feltham laboratory, we’re all about finding new and improved ways to fight chronic inflammation-driven diseases like cancer and Parkinson’s disease. We focus on discovering and targeting “undruggable” proteins that play a critical role in these diseases, using a cutting-edge technology; PROTACs.
PROTACs are a game-changer in the world of therapeutics, allowing us to target proteins that were previously considered impossible to tackle.
Our approach is simple but effective: identify, validate, and target. We screen for new disease proteins, then use the latest tech to make sure they’re worth designing drugs against. Finally, we use PROTACs to target those proteins, removing them entirely from the equation.
We’re making incredible strides towards a future where chronic inflammation can be cooled down and patients can live better lives. Together, we can make a real difference in the fight against chronic diseases.