Our researchers are using proteomics to better understand how proteins function in health and disease. This is providing new avenues for diagnosis and treatment of disease.
Our researchers are using proteomics to understand how proteins function within cells in health and disease. Important aspects include:
Our proteomics research is integrated with other research fields including:
Proteins are intricate molecules that are crucial for processes that make cells function. Proteomics studies the proteins produced by cells, called the proteome.
The proteomes of cells can vary:
Differences between how cells function occur because of the variations in their proteomes. These differences can be seen in:
These differences can be linked to changes that occur in cells to cause disease, or in response to a disease.
Studying proteomes can provide insights into cell behaviour that may not be reached by looking at a few individual proteins. Proteomics also allows researchers to discover previously unknown changes in individual proteins that may not have been considered in studies of single proteins.
Proteomics also complements genomics research, as changes in a cell’s genetic material do not always reflect changes within the proteome.
Cells contain thousands of different proteins that can be present in different amounts, and many proteins can be subtly modified. Our proteomics researchers rely on high-throughput techniques to rapidly assess and compare the proteomes of different samples.
Key aspects of our proteomics research include:
Many changes occurring within cells in health or disease are subtle and complex. Understanding slight changes in a cell’s genetic material (genome), coupled with changes in the proteome, can provide new insights into diseases.
Systems biology brings proteomic and genomic information together. This can be a powerful approach to understanding how diseases occur, and how they may be better diagnosed and treated.