Prof Sant-Rayn Pasricha, Lab Head | WEHI Researcher Profile

Q: Dissecting iron homeostasis in health and disease

Iron is essential for life. Tight control of bodily iron levels is critical since too much (iron overload) and too little (iron deficiency) both have untoward consequences. We are defining how iron levels are controlled under normal conditions as well as manipulating key players in iron regulation to further understand their role. This knowledge helps us determine how iron homeostasis is altered in diseases where iron regulation is perturbed (e.g. blood cancer, infectious diseases) and during distinct life stages (e.g. infancy, pregnancy).

Q: Studies in red blood cell production

We study erythropoiesis (red blood cell production) using a range of experimental techniques including genomic and epigenetic studies, live cell imaging, genome engineering and proteomics. Using these techniques we hope to find ways to improve red cell health and hence prevent and treat anaemia.

Q: Disorders of blood cell production and function

Through collaboration with Royal Melbourne Hospital and Peter MacCallum Cancer Centre we utilise samples from patients with a range of blood disorders, and apply state-of-the-art genomic, transcriptomic, and imaging technologies to define cellular and systemic changes caused by these conditions. Diseases studied include myeloproliferative neoplasms (e.g. Polycythaemia Vera, Essential Thrombocythaemia and Myelofibrosis).

Q: Placental signatures: unveiling the key to maternal and infant health

The placenta acts as a mediator for communication between the mother and fetus, facilitating the transfer of maternal nutrients, metabolites, immunoglobulins, and oxygen to the developing fetus. It also plays a crucial role in producing hormones that support fetal growth, eliminates fetal waste and carbon dioxide, and, importantly, enables the maternal immune system to tolerate the presence of fetal tissues. As a fetal organ, the delivered placenta represents a unique window into fetal development and metabolism.We are currently using established histopathology characterisation techniques together with advanced state-of-the-art spatial transcriptomic and imaging approaches to answer questions related to placental development, placental iron biology and transport, placental response to infection (such as Malaria) and inflammation and to evaluate the contribution of placental dysfunction to maternal, fetal and infant outcomes in our trial cohorts.

Q: Improving women's and children's health

Anaemia and undernutrition is very common in low- and middle-income countries, especially in pregnancy and in young children. We are undertaking a program of large randomised controlled trials in rural Bangladesh and Malawi to assess new solutions for anaemia control with the goal of improving maternal and child health, including pregnancy outcomes, maternal wellbeing, infection risk and child growth and development.

Q: Epigenetic regulation of iron homeostasis

Iron is critical for red blood cell development as well as every other tissue in the body. Absorption and distribution of iron is regulated by the liver-derived hormone, hepcidin. We have found that hepcidin expression is affected by gene-locus specific chromatin state and regulated by HDAC3.This project will use cutting edge genetic tools and epigenetic assays to establish the role of epigenetic regulation in systemic iron homeostasis, potentially opening new opportunities for treatments of patients with iron disorders.

Q: Improving menstrual health in low and middle-income countries

Menstrual health remains an understudied topic, with limited knowledge existing on the impacts and contributing factors of menstrual health issues, especially in low and middle-income countries. Women and girls in low and middle-income countries encounter multiple barriers in managing their menstrual health – and there is an urgent need to further define the issue and identify potential solutions. One consequence of poor menstrual health is menstrual-related absenteeism from school, work or social activities, hindering women's education, workforce participation and gender equity. Those women and girls who experience heavy menstrual bleeding may be particularly impacted. We are conducting research to understand contributing factors to menstrual-related absenteeism and evaluate new approaches to manage heavy menstrual bleeding with the aim to improve the health and wellbeing of women and girls in low and middle-income countries.

About

In the laboratory, we study how the master controller of systemic iron homoestasis, hepcidin, is regulated. Hepcidin is responsible for controlling iron absorption from the intestine and iron recycling from degraded red cells by the macrophage.

We are using novel epigenetic approaches to characterise new pathways which may regulate hepcidin gene expression. In addition, we are studying mechanisms by which erythropoiesis and anaemia may affect hepcidin expression.

In the field, we are undertaking large randomised controlled trials of iron interventions in rural Bangladesh (infants) and Malawi (pregnant women). These trials will provide much needed evidence to inform global health anaemia control policies. Samples from these trials will be available for analysis using cutting edge platforms including 16S rRNA gene sequencing for microbiota, CyTOF and flow cytometry, and molecular characterization, for example using high throughput RNA sequencing.

Finally, we assist and advise international and national organisations with research and policy development.

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Selected publications from Prof Sant-Rayn Pasricha

Larson LM, Baldi A, Hasan MI, Jones N, Owens Pickle E, Ataide R, Bennett C, Bhuiyan MSA, Tipu SMU, Tofail F, Biggs B-A, Hamadani J, Pasricha S-R, Braat S. Role of hepcidin on benefits and risks of supplementation with iron syrup and multiple micronutrient powders in Bangladeshi children: a sub-study to a randomized controlled trial. American Journal of Clinical Nutrition. 2025;121(5):10.1016/j.ajcnut.2025.02.018

Fielding KL, Bennett C, Pettikiriarachchi A, Jones N, Harding R, McLean ARD, Randall LM, Schaeper U, Martinez A, Ataide R, Pasricha S-R. Maternal Tmprss6 is required for hepcidin suppression and fetal health. Blood. 2025;:10.1182/blood.2024027563

Sertori R, Pasricha S-R. QTLs unlock RBC storage hemolysis secrets. Blood. 2025;145(7):10.1182/blood.2024027136

Starr M, Harding R, Ataíde R, Von Dinklage N, Sinharoy SS, Jayasinghe Y, Manda-Taylor L, Fisher J, Braat S, Pasricha S-R. Epidemiology of menstrual-related absenteeism in 44 low-income and middle-income countries: a cross-sectional analysis of Multiple Indicator Cluster Surveys. The Lancet Global Health. 2025;13(2):10.1016/s2214-109x(24)00468-6

Pasricha S-R, Moya E, Ataíde R, Mzembe G, Harding R, Mwangi MN, Zinenani T, Prang K-H, Kaunda J, Mtambo OPL, Vokhiwa M, Mhango G, Mamani-Mategula E, Fielding K, Demir A, Von Dinklage N, Verhoef H, McLean AR, Manda-Taylor L, Braat S, Phiri KS. Ferric carboxymaltose for anemia in late pregnancy: a randomized controlled trial. Nature Medicine. 2025;31(1):10.1038/s41591-024-03385-w

Pasricha S-R, Moya E, Ataíde R, Mzembe G, Harding R, Mwangi MN, Zinenani T, Prang K-H, Kaunda J, Mtambo OPL, Vokhiwa M, Mhango G, Mamani-Mategula E, Fielding K, Demir A, Von Dinklage N, Verhoef H, McLean AR, Manda-Taylor L, Braat S, Phiri KS. Author Correction: Ferric carboxymaltose for anemia in late pregnancy: a randomized controlled trial. Nature Medicine. 2025;31(1):10.1038/s41591-025-03492-2

Mzembe G, Moya E, Mwangi MN, Ataide R, Harding R, Kaunda J, Zinenani T, Mhango G, Stones W, Mtambo O, Demir AY, Verhoef H, Braat S, Pasricha S-R, Phiri KS. Postpartum maternal and infant haematological effects of second-trimester ferric carboxymaltose versus standard-of-care oral iron in Malawi: longitudinal follow-up of a randomised controlled trial. The Lancet Global Health. 2024;12(12):10.1016/s2214-109x(24)00380-2

Hasan MI, Ahmed S, McLean ARD, M Quaiyum Rahman A, Bhuiyan MSA, Tipu SMMU, Braat S, Arifeen SE, Hamadani JD, Pasricha S-R, Davidson EM. High anaemia and iron deficiency prevalence among pregnant women living in low groundwater iron areas of Bangladesh. BMC Public Health. 2024;24(1):10.1186/s12889-024-20480-2

Raman I, Bennett C, Juneja S, Yannakou CK, Indran T, Pasricha S-R. Dysregulated Complement Activation in Polycythemia Vera: A Novel Mechanism for Thrombosis in Myeloproliferative Neoplasms Uncovered By Proteomic Analysis. Blood. 2024;144(Supplement 1):10.1182/blood-2024-206614

Bennett C, Pettikiriarachchi A, McLean ARD, Harding R, Blewitt ME, Seillet C, Pasricha S. Serum iron and transferrin saturation variation are circadian regulated and linked to the harmonic circadian oscillations of erythropoiesis and hepatic Tfrc expression in mice. American Journal of Hematology. 2024;99(11):10.1002/ajh.27447

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Lab research projects

Dissecting iron homeostasis in health and disease

Studies in red blood cell production

Disorders of blood cell production and function

Placental signatures: unveiling the key to maternal and infant health

Improving women’s and children’s health

Epigenetic regulation of iron homeostasis

Improving menstrual health in low and middle-income countries

Student research projects

Improving maternal and childhood health in low income settings

Graduate Research Masters/Honours/Masters by Coursework/PhD

More information

Disorders of red blood cell and iron physiology

Graduate Research Masters/Honours/Masters by Coursework/PhD

More information

Improving maternal and childhood health in low income settings

Graduate Research Masters/Honours/Masters by Coursework/PhD

More information

Disorders of red blood cell and iron physiology

Graduate Research Masters/Honours/Masters by Coursework/PhD

More information

View all student research projects

Prof Sant-Rayn Pasricha

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