Call Lab

Division Head
Laboratory Head
13 members

About the lab

Each of our bodies contain trillions of cells that work together to make up a human and each and every one of those cells needs to coordinate with its neighbours to know what to do and when. Many of these external cues are sensed by receptors that sit at the surface of cells and transmit information from the outside of the cell to the interior causing cell behaviour to change depending on the environmental changes in any given instant.

Our laboratory studies the structure and function of cellular sensors that direct blood cell development and immune responses. These sensors, also called receptors, receive physiological cues such as growth hormones, stress signals and signs of infection, and translate them into biochemical reactions that drive cellular responses.

We are interested in understanding:

  • how these receptors do their work as biochemical translators of information
  • what happens when they don’t function correctly, for example cancer, immunodeficiency and other blood diseases; and
  • how we can use this knowledge to build better custom sensors for adoptive cell therapies such as chimeric antigen receptor (CAR) T-cell immunotherapy.

Our mission

Our mission is to translate fundamental discoveries about how natural immune sensors work into new diagnostic and therapeutic applications.

Lab research projects

Lab team

Most projects are led cooperatively by Matthew Call and Melissa Call, with particular aspects of training and project management directed by Matthew or Melissa according to particular areas of expertise.

13 members
Corinna Clemens
Visiting International Masters Student
Pranav Runwal
Visiting PhD Student
Xinyu Wu
PhD Student
Research Officer
Dr Lincoln Smith
Research Assistant
Senior Research Officer
Dr Colin Hockings
Senior Research Officer
Senior Research Officer
Research Assistant
Research Officer
Margareta Go
Research Assistant
Interested in supporting our research?

Your support will help WEHI’s researchers make discoveries and find treatments to ensure healthier, longer lives for you and your loved ones.

Contact our friendly team to find out how you can help.