As a haematologist, I am interested in how blood cells are produced from stem cells, and how this process is corrupted in blood diseases. Blood cells are critical for health and wellbeing. They carry oxygen throughout the body, fight infection and control bleeding. Throughout our lifetime, blood cells need to be replaced in a constant, tightly controlled manner.
Our division has revealed many of the genes that are critical for blood cell development. Many of these genes are also involved in the development of blood diseases, such as leukaemia and lymphoma in children, adolescents and adults. By understanding the processes that control blood cell development, I aim to advance the treatment of blood diseases for both children and adults.
Our laboratory focuses on the use of genetic approaches to decipher mechanisms which regulate blood cells in normal development and disease. This involves in vitro and in vivo model systems which can be manipulated to understand how genes such as transcription factors, signaling molecules and cell receptors control these processes.
By integrating fundamental biology with translational approaches using genomics and chemical biology, we aim to develop a strong basis for the understanding of blood development and disease, to allow precision medicine approaches for rational drug design.
My research interests are:
Australia, University of Melbourne, BMedSci MBBS(Hons)
Australia, University of Melbourne, FRACP FRCPA PhD
1995 Bachelor of Medical Science Prize, The University of Melbourne
2011-2013 Leukaemia Foundation Australia/Cure Cancer Australia Post-Doctoral Award
2008-2010 NHMRC Postgraduate Award
2014-2016 NHMRC Project Grant
2011-2014 Lions Fellowship, Cancer Council of Victoria
2012-2014 Leukaemia Foundation Annual Patient Conference Speaker
2013-2014 Victorian Comprehensive Cancer Centre IM-ICT Committee
2007 Joint Supervisory Advisory Committee, Royal Australasian College of Physicians, Royal College of Pathologists Australasia
2006 Royal Australasian College of Physicians, Victoria Basic and Advanced Trainee Representative
Ng AP, Kauppi M, Metcalf D, Hyland CD, Josefsson EC, Lebois M, Zhang JG, Baldwin TM, Di Rago L, Hilton DJ, Alexander WS. Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation. Proc Natl Acad Sci U S A. 2014 Apr 7;111(16):5884-9. PMID: 24711413.
Stevenson WS, Morel-Kopp MC, Chen Q, Liang HP, Bromhead CJ, Wright S, Turakulov R, Ng AP, Roberts AW, Bahlo M, Ward CM. GFI1B mutation causes a bleeding disorder with abnormal platelet function. J Thromb Haemost. 2013 Nov;11(11):2039-47. PMID: 23927492.
Tang JZ, Carmichael CL, Shi W, Metcalf D, Ng AP, Hyland CD, Jenkins NA, Copeland NG, Howell VM, Zhao ZJ, Smyth GK, Kile BT, Alexander WS. Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6091-6. PMID: 23533276.
Ng AP, Kauppi M, Metcalf D, Di Rago L, Hyland CD, Alexander WS. Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2364-9. PMID: 22308484.
Ng AP, Hyland CD, Metcalf D, Carmichael CL, Loughran SJ, Di Rago L, Kile BT, Alexander WS. Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood. 2010 May 13;115(19):3966-9. PMID: 20007548.