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About

As a haematologist, I am interested in how blood cells are produced from stem cells, and how this process is corrupted in blood diseases. Blood cells are critical for health and wellbeing. They carry oxygen throughout the body, fight infection and control bleeding. Throughout our lifetime, blood cells need to be replaced in a constant, tightly controlled manner.

Our division has revealed many of the genes that are critical for blood cell development. Many of these genes are also involved in the development of blood diseases, such as leukaemia and lymphoma in children, adolescents and adults. By understanding the processes that control blood cell development, I aim to advance the treatment of blood diseases for both children and adults.

Publications

Selected publications from Dr Ashley Ng

Iland HJ, Reynolds J, Boddy AV, Schultz HB, Khoo L, Fleming S, Lane SW, Weber N, Gasiorowski R, Armytage T, Harrup R, Watson A-M, Tan P, Filshie R, Kwok F, Stevenson W, Yuen S, Ng AP, Rowley L, Marlton P, Wei AH, Group. ALAL, Batt T, Bazargan A, Bryant C, Bokhari W, Calogero T, Chua C, Estell J, Hsu D, Kwan J, Leahy M, Lyons A, Murphy N, Tam C, Thiagarajah N, Tiley C. ALLG APML5: Bioavailability and safety of oral arsenic trioxide assessed during consolidation therapy for APL. Blood Advances. 2025;:10.1182/bloodadvances.2024015397

Nie J, Ng AP, Nutt SL. Post-translational control of B lineage commitment. Nature Immunology. 2024;25(12):10.1038/s41590-024-02019-0

Anderton H, Bandala-Sanchez E, Simpson DS, Rickard JA, Ng AP, Di Rago L, Hall C, Vince JE, Silke J, Liccardi G, Feltham R. Correction to: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development. Cell Death & Differentiation. 2024;31(12):10.1038/s41418-024-01401-7

Kremyanskaya M, Hoffman R, Chew LP, Sharif A, Semov B, Kori AN, Sia H, Grove CS, Ng AP, Kalro A, Raman I, Kasinathan G, Oduwole O, Gomez-Palou M, Fok H, Romano S, Rambaran C, Martinez A. Initial Results from a Phase 1/2 Study Evaluating Divesiran, a Novel Galnac Conjugated siRNA, in Patients with Polycythemia Vera (SANRECO). Blood. 2024;144(Supplement 1):10.1182/blood-2024-205854

Pitiyarachchi O, King MT, Gangatharan S, Osborn M, Ng AP, Fleming S, Fedele P, Trahair TN, Casey J, Mapp S, Cheung CC, Armytage T, McCloud P, Button P, Rowley L, Larsen SR, Presgrave P, Kwan J, Bennett S, Fong CY, Dalla-Pozza L, Greenwood M. Health-Related Quality of Life in Adolescents and Young Adults Treated with Blinatumomab Consolidation for CD19+ Ph-Negative Acute Lymphoblastic Leukemia in the Australasian Lymphoma and Leukaemia Group (ALLG) ALL09 “Sublime” Study. Blood. 2024;144(Supplement 1):10.1182/blood-2024-209043

Ng AP. Catch ’em all! CDK9’s RUNX1 mega evolution. Blood. 2024;144(17):10.1182/blood.2024026377

Ng AP. Hit the road JAK, don’t P-STAT, stem more!. Blood. 2024;144(7):10.1182/blood.2024025441

Vu M, Degeling K, Ryland GL, Hofmann O, Ng AP, Westerman D, IJzerman MJ. Economic Impact of Whole Genome Sequencing and Whole Transcriptome Sequencing Versus Routine Diagnostic Molecular Testing to Stratify Patients with B-Cell Acute Lymphoblastic Leukemia. Journal of Molecular Diagnostics. 2024;26(8):10.1016/j.jmoldx.2024.04.006

Ng AP, Adams R, Tiong IS, Seymour L, Talaulikar D, Palfreyman E, Enjeti A, Tate C. Reporting bone marrow biopsies for myelodysplastic neoplasms and acute myeloid leukaemia incorporating WHO 5th edition and ICC 2022 classification systems: ALLG/RCPA joint committee consensus recommendations. Pathology. 2024;56(4):10.1016/j.pathol.2024.02.002

Behrens K, Brajanovski N, Xu Z, Viney EM, DiRago L, Hediyeh-Zadeh S, Davis MJ, Pearson RB, Sanij E, Alexander WS, Ng AP. ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemia. Science Advances. 2024;10(10):10.1126/sciadv.adj8803

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