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About

As a haematologist, I am interested in how blood cells are produced from stem cells, and how this process is corrupted in blood diseases. Blood cells are critical for health and wellbeing. They carry oxygen throughout the body, fight infection and control bleeding. Throughout our lifetime, blood cells need to be replaced in a constant, tightly controlled manner.

Our division has revealed many of the genes that are critical for blood cell development. Many of these genes are also involved in the development of blood diseases, such as leukaemia and lymphoma in children, adolescents and adults. By understanding the processes that control blood cell development, I aim to advance the treatment of blood diseases for both children and adults.

Publications

Selected publications from Dr Ashley Ng

DuVall AS, McNeer J, Cheung MC, Adrianzen-Herrera DA, Advani A, Aljurf M, Audino A, Benitez L, Deeter A, Dworkin E, Hiltbrand O, Isenalumhe L, Li L, Miller-Chism C, Mozessohn L, Ng AP, Pu JJ, Shafer D, Madueno FV, Viny A, Wadhwa A, Yang J, Zarnegar-Lumley S, Mai HJ, Kanaan G, Sereda Y, Saldanha IJ, Balk EM, Stock W, Wolfson JA. American Society of Hematology 2026 guidelines for frontline management of acute lymphoblastic leukemia in adolescents and young adults. Blood Advances. 2026;10(13):10.1182/bloodadvances.2021006469

Magtoto CM, Mieruszynski S, Dong H, Ng AP, Di Rago L, Kueh AJ, Brzozowski M, Grohmann C, Walker JR, Chua NK, Dagley LF, Ciulli A, Lessene G, Herold MJ, Heath JK, Silke J, Feltham R. The benchmarking and application of tag-degraders in vivo to validate therapeutic targets. Nature Communications. 2026;:10.1038/s41467-026-73681-1

Schenk P, Devine SM, Cobbold SA, Geoghegan ND, Kyran EL, Ang C-S, Alexandrovics JA, Calleja DJ, Multari DH, Vaibhav V, Lu BGC, Klemm TA, Dagley LF, Lowes KN, Williamson NA, Eichhorn PJA, Ng AP, Feltham R, Komander D. Global analysis of cancer cell responses to USP9X inhibition. The EMBO Journal. 2026;45(9):10.1038/s44318-026-00742-y

Ng AP, Nutt SL. Flicking the switch for B-cell development. Genes & Development. 2026;40(3-4):10.1101/gad.353397.125

Greenwood M, Gangatharan S, Osborn M, Ng AP, Fleming S, Fedele P, Trahair T, Casey J, Mapp S, Cheung C, Armytage T, Henderson M, Sutton R, Rehn J, Page E, Heatley S, Button P, Rowley L, Larsen SR, Presgrave P, Kwan J, Bennett S, Fong CY, Pozza LD, Yeung D, White D, Group TALAL. Blinatumomab in de novo AYA ALL—Results of the Australasian Leukaemia and Lymphoma Group ALL09 “SUBLIME” study. HemaSphere. 2026;10(1):10.1002/hem3.70291

Morel-Kopp M-C, Levade M, Beutler L, Chen Q, Othman J, Steffen P, McKay MJ, Molloy MP, Selvadurai MV, Liang HPH, Whittaker S, van der Wal DE, Gabrielli S, Hamilton JR, Chen VM, Ng AP, Ward CM, Stevenson WS. Growth factor independent 1B is a metabolic regulator that exerts pleiotropic effects on platelet function. Journal of Thrombosis and Haemostasis. 2025;23(10):10.1016/j.jtha.2025.06.021

Collett S, Earnest L, Edeling MA, Yap AHY, Montoya JC, Attard C, Di Rago L, Farley A, Ng AP, Monagle P, Torresi J. Adenovirus vectors can infect mouse megakaryocytes – implications for vaccine-induced thrombosis/thrombocytopenia. Research and Practice in Thrombosis and Haemostasis. 2025;9(4):10.1016/j.rpth.2025.102909

Iland HJ, Reynolds J, Boddy AV, Schultz HB, Khoo L, Fleming S, Lane SW, Weber N, Gasiorowski R, Armytage T, Harrup R, Watson A-M, Tan P, Filshie R, Kwok F, Stevenson W, Yuen S, Ng AP, Rowley L, Marlton P, Wei AH, Group ALAL. ALLG APML5: bioavailability and safety of oral arsenic trioxide assessed during consolidation therapy for APL. Blood Advances. 2025;9(6):10.1182/bloodadvances.2024015397

Nie J, Ng AP, Nutt SL. Post-translational control of B lineage commitment. Nature Immunology. 2024;25(12):10.1038/s41590-024-02019-0

Anderton H, Bandala-Sanchez E, Simpson DS, Rickard JA, Ng AP, Di Rago L, Hall C, Vince JE, Silke J, Liccardi G, Feltham R. Correction to: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development. Cell Death & Differentiation. 2024;31(12):10.1038/s41418-024-01401-7

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