We collaborate widely with scientists and clinicians to advanced proteomics technologies to identify and quantify proteins in cells and biofluids.

Our laboratory covers diverse range of areas that can be categorised into five key focus areas:

  • Interactions: Elucidation of protein-protein and protein-drug interactions
  • Protein dynamics: Investigating the mechanisms of protein function
  • Signalling: Investigation of signalling pathways (using phosphoproteomics and ubiquitin enrichment strategies)
  • Biomarkers: Identification of prognostic and diagnostic biomarkers of disease in biofluids
  • Epigenetics: Quantification of intact histones and their modifications in developmental and disease models

A/Prof Andrew Webb is Head of the Colonial Foundation Healthy Ageing Centre.


Selected publications from A/Prof Andrew Webb

Nachbur U, Stafford C, Bankovacki A, Zhan Y, Lindqvist L, Fiil B, Khakam Y, Ko HJ, Sandow J, Falk H, Holien J, Chau D, Hildebrand J, Vince J, Sharp P, Webb AI, Jackman K, Mühlen S, Kennedy C, Lowes K, Murphy J, Hansen MG, Parker M, Hartland E, Lew A, Huang D, Lessene G, and Silke J. A novel RIPK2 inhibitor delays NOD signalling complex formation yet prevents inflammatory cytokine production. Nature Communications. Accepted Jan 2015.

Hildebrand JM, Tanzer MC, Lucet IS, Young SN, Spall SK, Sharma P, Pierotti C, Garnier JM, Dobson RC, Webb AI, Tripaydonis A, Babon JJ, Mulcair MD, Scanlon MJ, Alexander WS, Wilks AF, Czabotar PE, Lessene G, Murphy JM, Silke J. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proceedings of the National Academy of Sciences. 111,42,15072-15077, 2014. PMID: 25288762

Wong W*, Webb AI*, Olshina MA, Infusini G, Tan YH, Hanssen E, Catimel B, Suarez C, Condron M, Angrisano F, Nebi T, Kovar DR, Baum J. A Mechanism for Actin Filament Severing by Malaria Parasite Actin Depolymerizing Factor 1 via a Low Affinity Binding Interface. Journal of Biological Chemistry. 289,7,4043-4054, 2014. PMID: 24371134

Chambers JM, Lindqvist LM, Webb AI, Huang DC, Savage GP, Rizzacasa MA. Synthesis of biotinylated Episilvestrol: highly selective targeting of the translation factors eIF4AI/II. Organic letters. 15,6,1406-1409, 2013. PMID: 23461621

Etemadi N, Webb AI, Bankovacki A, Silke J, Nachbur U. Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1. Immunology and cell biology. 91(10) 661-4, 2013. PMID: 24100384

Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Lung TW, Mansell A, Riedmaier P, Oates CV, Zaid A, Mühlen S, Crepin VF, Marches O, Ang CS, Williamson NA, O’Reilly LA, Bankovacki A, Nachbur U, Infusini G, Webb AI, Silke J, Strasser A, Frankel G, Hartland EL. A type III effector antagonizes death receptor signalling during bacterial gut infection, Nature, 501,7466,247-251, 2013. PMID: 24025841

Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS., The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism, Immunity, 39,3,443-453, 2013. PMID: 24012422

Dejnirattisai W*, Webb AI*, Chan V, Jumnainsong A, Davidson A, Mongkolsapaya J, Screaton G. Lectin switching during dengue virus infection. Journal of Infectious Diseases. 203,12,1775-1783, 2011. PMID: 21606536

Gerlach B*, Cordier SM*, Schmukle AC*, Emmerich CH*, Rieser E*, Haas TL*, Webb AI*, Rickard JA, Anderton H, Wong WW, Nachbur U, Gangoda L, Warnken U, Purcell AW, Silke J, Walczak H. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature. 471,7340,591-596, 2011. PMID: 21455173

Theodossis A1, Guillonneau C, Welland A, Ely LK, Clements CS, Williamson NA, Webb AI, Wilce JA, Mulder RJ, Dunstone MA, Doherty PC, McCluskey J, Purcell AW, Turner SJ, Rossjohn J. Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition. Proceedings of the National Academy of Sciences. 107,12,5534-5539, 2010. PMID: 20212169

Lab research projects

Interested in supporting our research?

Your support will help WEHI’s researchers make discoveries and find treatments to ensure healthier, longer lives for you and your loved ones.

Contact our friendly team to find out how you can help.