-
Diseases
Themes / Divisions
  • New Medicines and Advanced Technologies
  • Colonial Foundation Healthy Ageing Centre

About

We collaborate widely with scientists and clinicians to advanced proteomics technologies to identify and quantify proteins in cells and biofluids.

Our laboratory covers diverse range of areas that can be categorised into five key focus areas:
* Interactions: Elucidation of protein-protein and protein-drug interactions
* Protein dynamics: Investigating the mechanisms of protein function
* Signalling: Investigation of signalling pathways (using phosphoproteomics and ubiquitin enrichment strategies)
* Biomarkers: Identification of prognostic and diagnostic biomarkers of disease in biofluids
* Epigenetics: Quantification of intact histones and their modifications in developmental and disease models

Publications

Selected publications from A/Prof Andrew Webb

Emery‐Corbin SJ, Yousef JM, Adhikari S, Sumardy F, Nhu D, van Delft MF, Lessene G, Dziekan J, Webb AI, Dagley LF. Improved drug target deconvolution with PISA‐DIA using an extended, overlapping temperature gradient. Proteomics. 2024;:10.1002/pmic.202300644

Dagley LF, Yousef J, Preaudet A, Loving A, Webb AI, Ernst M, Putoczki TL. Identification of Serum Biomarkers to Monitor Therapeutic Response in Intestinal-Type Gastric Cancer. International Journal of Molecular Sciences. 2024;25(6):10.3390/ijms25063129

Nicolson S, Manning JA, Lim Y, Jiang X, Kolze E, Dayan S, Umargamwala R, Xu T, Sandow JJ, Webb AI, Kumar S, Denton D. The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy. Communications Biology. 2024;7(1):10.1038/s42003-024-05834-1

Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang J-G, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NPD, Linossi EM, Burns CJ, Carotta S, Gray DHD, Seillet C, Hutchinson DS, Belz GT, Webb AI, Alexander WS, Li SS, Bullock AN, Babon JJ, Smyth MJ, Nicholson SE, Huntington ND. Author Correction: CIS is a potent checkpoint in NK cell–mediated tumor immunity. Nature Immunology. 2024;25(2):10.1038/s41590-023-01714-8

Fietz D, Sgaier R, O’Donnell L, Stanton PG, Dagley LF, Webb AI, Schuppe H-C, Diemer T, Pilatz A. Proteomic biomarkers in seminal plasma as predictors of reproductive potential in azoospermic men. Frontiers in Endocrinology. 2024;15:10.3389/fendo.2024.1327800

Horne CR, Oliver MR, Shrestha S, Keown JR, Liang L-Y, Young SN, Sandow JJ, Webb AI, Goldstone DC, Lucet IS, Kannan N, Metcalf P, Murphy JM. It takes two to tango: structure of viral kinase PK-1 reveals a new mode of kinase regulation. Acta Crystallographica Section A: Foundations and advances. 2023;79(a2):10.1107/s2053273323087715

Hediyeh-Zadeh S, Webb AI, Davis MJ. MsImpute: Estimation of Missing Peptide Intensity Data in Label-Free Quantitative Mass Spectrometry. Molecular & Cellular Proteomics. 2023;22(8):10.1016/j.mcpro.2023.100558

Pandey K, Wang SS, Mifsud NA, Faridi P, Davenport AJ, Webb AI, Sandow JJ, Ayala R, Monje M, Cross RS, Ramarathinam SH, Jenkins MR, Purcell AW. A combined immunopeptidomics, proteomics, and cell surface proteomics approach to identify immunotherapy targets for diffuse intrinsic pontine glioma. Frontiers in Oncology. 2023;13:10.3389/fonc.2023.1192448

Mintern J, Liu H, Webb A, Johnston A, Villadangos J. New participants and pathways in immune receptor trafficking. Molecular Immunology. 2022;150:10.1016/j.molimm.2022.05.061

Liu L, Sandow JJ, Leslie Pedrioli DM, Samson AL, Silke N, Kratina T, Ambrose RL, Doerflinger M, Hu Z, Morrish E, Chau D, Kueh AJ, Fitzibbon C, Pellegrini M, Pearson JS, Hottiger MO, Webb AI, Lalaoui N, Silke J. Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death. Science Advances. 2022;8(19):10.1126/sciadv.abh2332

Lab research projects

Interested in supporting our research?

Your support will help WEHI’s researchers make discoveries and find treatments to ensure healthier, longer lives for you and your loved ones.

Contact our friendly team to find out how you can help.