Blood cancers: Research & Insights

Q: Key discoveries made by WEHI’s blood cancer researchers include:

Discovering the growth factors that keep normal and cancerous blood cells alive and pioneering the use of these growth factors to accelerate recovery from chemotherapy and enable blood stem cell transplantation Revealing how certain proteins keep blood cancers alive Contributing to the development and clinical testing of new drugs that force blood cancers to die Explaining how leukaemias can become resistant to anti-cancer drugs Uncovering genetic changes that cause blood cancers Discovering how a key cancer-fighting gene prevents blood cancer

Q: What are blood cancers?

Cancers arise through genetic changes in cells that make them divide and grow uncontrollably. Blood cancers arise from changes in cells of the blood system, often either developing blood cells or immune (white blood) cells. They cause illness by depriving other cells of the space and nutrients they need to function properly.

Q: Our research focuses on a number of different types of blood cancers:

Leukaemia: cancers of immature blood-forming cells Lymphoma: cancers of lymphocytes (and immune cell type) that invade lymphatic tissue such as the lymph nodes or spleen as well as the bone marrow. Myeloma: cancers of antibody-producing plasma cells that arise in the bone marrow Myeloproliferative diseases: cancer-like diseases in which too many mature blood cells are produced in the bone marrow

Q: Support for people with blood cancers

Our researchers are not able to provide specific medical advice specific to individuals. If you have cancer and wish to find out more information about clinical trials, please visit the Australian Cancer Trials or the Australian New Zealand Clinical Trials Registry, or consult your medical specialist. The following organisations provide support for people with specific cancer types and their carers: Leukaemia Foundation Lymphoma Australia Myeloma Australia Myeloproliferative Neoplasms Research Foundation Cancer Council

Introduction

Our researchers are working to understand why blood cancers arise, and developing better treatments. Our goal is to improve the survival of people with blood cancer.

Our blood cancer research

WEHI’s research into blood cancer spans from investigating the molecules that drive blood cancers through to drug development and testing, and involvement in clinical trials.

We particularly focus on:

Defining the genetic and molecular changes that cause blood cancers
Uncovering how blood cancers become resistant to treatment
Discovering molecular targets in blood cancers
Developing and testing new drugs to treat blood cancers
Undertaking pre-clinical and clinical studies of new therapies for blood cancer.

WEHI’s blood cancer research spans more than 60 years and has underpinned the development of new medicines that have improved treatment for millions of patients.