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- A new regulator of stemness to create dendritic cell factories for immunotherapy
- Advanced methods for genomic rearrangement detection
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- Defining the protein modifications associated with respiratory disease
- Delineating the pathways driving cancer development and therapy resistance
- Developing a new drug that targets plasmacytoid dendritic cells for the treatment of lupus
- Development and mechanism of action of novel antimalarials
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- Development of tau-specific therapeutic and diagnostic antibodies
- Discovering novel therapies for major human pathogens
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- Essential role of glycobiology in malaria parasites
- Evolution of haematopoiesis in vertebrates
- Human lung protective immunity to tuberculosis
- Identifying novel treatment options for ovarian carcinosarcoma
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigating the role of mutant p53 in cancer
- Microbiome strain-level analysis using long read sequencing
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Modelling spatial and demographic heterogeneity of malaria transmission risk
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Structural basis of catenin-independent Wnt signalling
- Structure and biology of proteins essential for Toxoplasma parasite invasion
- T lymphocytes: how memories are made
- TICKER: A cell history recorder for longitudinal patient monitoring
- Targeting host pathways to develop new broad-spectrum antiviral drugs
- Targeting post-translational modifications to disrupting the function of secreted proteins
- Targeting the epigenome to rewire pro-allergic T cells
- Targeting the immune microenvironment to treat KRAS-mutant adenocarcinoma
- The E3 ubiquitin ligase Parkin and mitophagy in Parkinson’s disease
- The molecular controls on dendritic cell development
- Understanding malaria infection dynamics
- Understanding the genetics of neutrophil maturation
- Understanding the neuroimmune regulation of innate immunity
- Understanding the proteins that regulate programmed cell death at the molecular level
- Using cutting-edge single cell tools to understand the origins of cancer
- When healthy cells turn bad: how immune responses can transition to lymphoma
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Gray-Lab team
Researcher:
Lab team
I lead a multidisciplinary, highly motivated team committed to elucidating the molecular and cellular basis of immunological tolerance. We collaborate closely with groups at the Institute, Monash University, Harvard Medical School, The University of Basel and the VIB (Belgium).
Julie Sheridan, Senior Postdoctoral Fellow, BSc(Hons) Leeds PhD Edinburgh
Project: Molecular control of thymic epithelial cell death and differentiation
Key Publication: Sheridan JM, Keown A, Policheni A, Roesley SNA, Rivlin N, Kadouri N, Ritchie ME, Jain R, Abramson J, Heng TSP and Gray DHD. Thymospheres are formed by mesenchymal cells with the potential to generate adipocytes but not epithelial cells. Cell Rep. 2017. 21; 934-942. PMID: 29069601
Antonia Policheni, Postdoctoral Fellow, BSc(Hons) Melbourne BBiomedSc Monash PhD Melbourne
Project: How apoptosis controls competition among T cell progenitors in the thymus
Key Publication: Nolan E, Savas P, Policheni AN, Darcy PK, Vaillant F, Mintoff CP, Dushyanthen S, Mansour M, Pang JB, Fox SB, Kathleen Cuningham Foundation Consortium for Research into Familial Breast C, Perou CM, Visvader JE, Gray DHD*, Loi S*, Lindeman GJ*. (*co-senior authors) Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer. Sci Transl Med 2017; 9(393). PMID: 28592566
Charis Teh, Postdoctoral Fellow, BSc(Hons) ANU PhD ANU
Projects: Treg development and homeostasis; Mass cytometric analysis of blood cancer cell death
Key Publication: Teh, Lalaoui, Jain, Policheni, Heinlein, Alvarez-Diaz, Sheridan, Rieser, Deuser, Darding, Koay, Hu, Kupresanin, O’Reilly, Godfrey, Smyth, Bouillet, Andreas Strasser, Walczak, John Silke and Gray. Linear Ubiquitin Chain Assembly Complex Coordinates Late Thymic T Cell Differentiation and Regulatory T Cell Homeostasis Nat. Comm. 2016 Nov 18;7:13353. doi: 10.1038/ncomms13353 PMID: 27857075
Clare Weeden, Postdoctoral Fellow, BA UWA BSc(Hons) UWA PhD Melbourne
Project: Deep profiling of lung cancer, their metastases and the immune microenvironment
Key Publication: Weeden CE, Ah-Cann C, Holik AZ, Pasquet J, Garnier JM, Merino D, Lessene G, Asselin-Labat ML. Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition. Oncogene. 2018. Doi:10.1038/s41388-018-0268-2. PMID: 29743589
Melanie Heinlein, PhD Student, BSc Masters (Molecular Medicine) Albert-Ludwigs-University
Project: The mechanisms of stromal cell death and survival in the thymus and bone marrow
Key Publication: Jain R, Sheridan JM, Policheni AN, Heinlein M, Gandolfo LC, Dewson G, Smyth GK, Sansom SN, Fu, NY, Visvader JE, Hollander GA, Strasser A and Gray DHD. A critical epithelial survival axis regulated by MCL-1 maintains thymic epithelial cell function in mice. Blood. 2017. 130 (23): 2504-2515. PMID: 28972012
Alissa Robbins, PhD student, BMedSc(Hons) Sydney
Project: TNF receptor signalling in T cell differentiation and function
Tania Tan, Research Assistant, BSc(Hons) Melbourne
Project: Mass cytometric analysis of blood cancer cell death