Lab team

I lead a multidisciplinary, highly motivated team committed to elucidating the molecular and cellular basis of immunological tolerance. We collaborate closely with groups at the Institute, Monash University, Harvard Medical School, The University of Basel and the VIB (Belgium).

Julie Sheridan Senior Postdoctoral Fellow BSc(Hons) Leeds PhD Edinburgh

Project: Molecular control of thymic epithelial cell death and differentiation

Key Publication: Sheridan J, Gray D. Reinforcing the 'gauntlet' of thymic negative selection via exosomal transfer of self-antigens. Immunol Cell Biol. 2015 Sep;93(8):679-80. PMID: 26032582

Reema Jain Postdoctoral Fellow MSc Auckland PhD Melbourne

Project: Thymic epithelial cell homeostasis and differentiation

Key Publication: Jain R, Gray DHD. Isolation and Analysis of Thymic Epithelial Cells by Flow Cytometry. Curr Protoc Immunol. 2014 Nov 3;107:3.26.1-15. PMID: 25367128

Charis Teh Postdoctoral Fellow BSc(Hons) ANU PhD ANU

Project: Treg development and homeostasis

Key Publication: Teh, Lalaoui, Jain, Policheni, Heinlein, Alvarez-Diaz, Sheridan, Rieser, Deuser, Darding, Koay, Hu, Kupresanin, O’Reilly, Godfrey, Smyth, Bouillet, Andreas Strasser, Walczak, John Silke and Gray. Linear Ubiquitin Chain Assembly Complex  Coordinates Late Thymic T Cell Differentiation and Regulatory T Cell Homeostasis Nat. Comm. 2016 Nov 18;7:13353. doi: 10.1038/ncomms13353 PMID: 27857075

Melanie Heinlein PhD Student BSc Masters (Molecular Medicine) Albert-Ludwigs-University

Project: The mechanisms of stromal cell death and survival in the thymus and bone marrow

Key Publication: Teh, Lalaoui, Jain, Policheni, Heinlein, Alvarez-Diaz, Sheridan, Rieser, Deuser, Darding, Koay, Hu, Kupresanin, O’Reilly, Godfrey, Smyth, Bouillet, Andreas Strasser, Walczak, John Silke and Gray. Linear Ubiquitin Chain Assembly Complex  Coordinates Late Thymic T Cell Differentiation and Regulatory T Cell Homeostasis Nat. Comm. 2016 Nov 18;7:13353. doi: 10.1038/ncomms13353 PMID: 27857075

Antonia Policheni PhD Student BSc(Hons) Melbourne BBiomedSc Monash

Project: How does deletional tolerance integrate with anergy?

Key Publication: Pierson W, Cauwe B, Policheni A, Schlenner SM, Franckaert D, Berges J, Humblet-Baron S, Schönefeldt S, Herold MJ, Hildeman D, Strasser A, Bouillet P, Lu LF, Matthys P, Freitas AA, Luther RJ, Weaver CT, Dooley J, Gray DH, Liston A. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells. Nat. Immunol. 2013 Sep;14(9):959-65. PMID: 23852275