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About

I am the Proteomics Facility manager at The Walter and Eliza Hall Institute (WEHI). I have over 13 years’ experience in the application of novel mass spectrometry and proteomics technologies to address key research questions in the fields of infectious & inflammatory diseases and cancer. In 2009, I received a postgraduate scholarship from Multiple Sclerosis Research Australia to pursue my PhD with Prof. Tony Purcell (Monash). In 2010, I was awarded funding from multiple sources to continue my PhD research at the University of Toronto, Canada (with Prof. Andrew Emili). Here, I received world-class training in the use of mass spectrometry instruments and published collaborative research in top-tier proteomics journals. During my postdoctoral training at WEHI with Dr. Sandra Nicholson (2013-2015) and then A/Prof. Andrew Webb (2015-2020), I applied my comprehensive mass spectrometry training to address novel research questions, facilitating a range of productive research collaborations resulting in 8 first/co-first author publications in leading journals (including Nature Immunology). I am an active board member of the Australasian Proteomics Society (APS) executive committee and the Human Proteome Organisation (HUPO) Award committee.

Publications

Selected publications from Dr Laura Dagley

Cagigas ML, Masedunskas A, Lin Y, Emery‐Corbin SJ, Yousef JM, Dagley LF, Olechnowicz S, Bowden R, Hayward R, Low G, Muirhead R, Brand‐Miller J, Fogeltholm M, Raben A, Demaria M, Fuller SJ, Fontana L. Short‐Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study. Aging Cell. 2025;:10.1111/acel.70123

Kuo SF-T, Spall S, Emery-Corbin SI, Mohamed A, Dite T, Chow K, Hughes P, Dagley LF, Webb AI. Quantitative Proteomic Analysis Unveils Protein Concentration Effects in Neat Urine Compared to Urine Extracellular Vesicles. Journal of Proteome Research. 2025;:10.1021/acs.jproteome.5c00060

Pascual R, Cheng J, De Smet AH, Capaldo BD, Tsai M, Kordafshari S, Vaillant F, Song X, Giner G, Milevskiy MJG, Jackling FC, Pal B, Dite T, Yousef J, Dagley LF, Smyth GK, Fu N, Lindeman GJ, Chen Y, Visvader JE. Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis. The EMBO Journal. 2025;44(11):10.1038/s44318-025-00422-3

Foot NJ, Dinh DT, Emery‐Corbin SJ, Yousef JM, Dagley LF, Russell DL. Comparative Analysis of the Progesterone Receptor Interactome in the Human Ovarian Granulosa Cell Line KGN and Other Female Reproductive Cells. Proteomics. 2025;:10.1002/pmic.202400374

Callegari S, Kirk NS, Gan ZY, Dite T, Cobbold SA, Leis A, Dagley LF, Glukhova A, Komander D. Structure of human PINK1 at a mitochondrial TOM-VDAC array. Science. 2025;388(6744):10.1126/science.adu6445

Cai T, Emery-Corbin SJ, McCafferty C, Van Den Helm S, Letunica N, Barton R, Attard C, Horton S, Bottrell S, Schultz B, MacLaren G, Chiletti R, Best D, Johansen A, Newall F, Butt W, d’Udekem Y, Dagley LF, Yousef JM, Monagle P, Ignjatovic V. Characterization of Protein Binding on an Extracorporeal Membrane Oxygenation (ECMO) Circuit Following the Priming Procedure. ASAIO Journal. 2025;71(4):10.1097/mat.0000000000002273

Kauppi M, Hyland CD, Viney EM, White CA, de Graaf CA, Welch AE, Yousef J, Dagley LF, Emery-Corbin SJ, Di Rago L, Kueh AJ, Herold MJ, Hilton DJ, Babon JJ, Nicola NA, Behrens K, Alexander WS. Cullin-5 controls the number of megakaryocyte-committed stem cells to prevent thrombocytosis in mice. Blood. 2025;145(10):10.1182/blood.2024025406

Horne CR, Dite TA, Young SN, Mather LJ, Dagley LF, Johnson JL, Yaron-Barir TM, Huntsman EM, Daly LA, Byrne DP, Cadell AL, Ng BH, Yousef J, Multari DH, Shen L, McAloon LM, Manning G, Febbraio MA, Means AR, Cantley LC, Tanzer MC, Croucher DR, Eyers CE, Eyers PA, Scott JW, Murphy JM. PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(8):10.1073/pnas.2420961122

Geyer PE, Hornburg D, Pernemalm M, Hauck SM, Palaniappan KK, Albrecht V, Dagley LF, Moritz RL, Yu X, Edfors F, Vandenbrouck Y, Mueller-Reif JB, Sun Z, Brun V, Ahadi S, Omenn GS, Deutsch EW, Schwenk JM. The Circulating ProteomeTechnological Developments, Current Challenges, and Future Trends. Journal of Proteome Research. 2024;23(12):10.1021/acs.jproteome.4c00586

Leinenga G, To XV, Bodea L-G, Yousef J, Richter-Stretton G, Palliyaguru T, Chicoteau A, Dagley L, Nasrallah F, Götz J. Correction: Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry. 2024;29(12):10.1038/s41380-024-02616-3

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