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About

I am the Proteomics Facility manager at The Walter and Eliza Hall Institute (WEHI). I have over 13 years’ experience in the application of novel mass spectrometry and proteomics technologies to address key research questions in the fields of infectious & inflammatory diseases and cancer. In 2009, I received a postgraduate scholarship from Multiple Sclerosis Research Australia to pursue my PhD with Prof. Tony Purcell (Monash). In 2010, I was awarded funding from multiple sources to continue my PhD research at the University of Toronto, Canada (with Prof. Andrew Emili). Here, I received world-class training in the use of mass spectrometry instruments and published collaborative research in top-tier proteomics journals. During my postdoctoral training at WEHI with Dr. Sandra Nicholson (2013-2015) and then A/Prof. Andrew Webb (2015-2020), I applied my comprehensive mass spectrometry training to address novel research questions, facilitating a range of productive research collaborations resulting in 8 first/co-first author publications in leading journals (including Nature Immunology). I am an active board member of the Australasian Proteomics Society (APS) executive committee and the Human Proteome Organisation (HUPO) Award committee.

Publications

Selected publications from Dr Laura Dagley

Horne CR, Wang T, Young SN, Dite TA, Nyvall HG, Suresh S, Davies KA, Castro AG, Vaibhav V, Mather LJ, Dagley LF, Belousoff MJ, Manning G, Means AR, Burke JE, Petersen J, Scott JW, Murphy JM. Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity. Biochemical Journal. 2025;482(23):10.1042/bcj20253431

Liu H, Francis L, Dagley LF, Cobbold SA, Webb AI, Komander D, Villadangos JA, Mintern JD. Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain. Scientific Reports. 2025;15(1):10.1038/s41598-025-25817-4

Black KA, Mobbs JI, Venugopal H, Dite TA, Leis A, Wong LL, Dagley LF, Thal DM, Glukhova A. Structural basis for Porcupine inhibition. Communications Chemistry. 2025;8(1):10.1038/s42004-025-01726-5

Raman I, Bennett C, Pettikiriarachchi A, Ataide R, Zhu Y, Tsui E, Juneja S, Emery-Corbin S, Spall S, Yousef J, Dagley L, Yannakou C, Pasricha S-R. Characterisation of the megakaryocyte proteome in patients with Philadelphia negative myeloproliferative neoplasms. Blood. 2025;146(Supplement 1):10.1182/blood-2025-5539

Keragala CB, Emery-Corbin SJ, Olechnowicz SW, Yousef J, Bowden R, Attard C, Dagley LF, Medcalf RL, Monagle P, Chunilal S, Tran H, McFadyen J, Stevens H, Ho H. P-018 Alterations in pathways of complement and platelet signalling are evident following proteome profiling of plasma from patients with Vaccine Induced Immune Thrombotic Thrombocytopenia (VITT). Journal of Thrombosis and Haemostasis. 2025;23:10.1016/s1538-7836(25)00782-2

Dietrich MH, Chmielewski J, Chan L-J, Tan LL, Adair A, Lyons FMT, Gabriela M, Lopaticki S, Dite TA, Dagley LF, Pazzagli L, Gupta P, Kamil M, Vaughan AM, Rojrung R, Abraham A, Mazhari R, Longley RJ, Zeglinski K, Gouil Q, Mueller I, Fabb SA, Shandre-Mugan R, Pouton CW, Glukhova A, Shakeel S, Tham W-H. Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex. Science. 2025;389(6765):10.1126/science.ady0241

Cooney JP, Hirons A, Jansz N, Allison CC, Hickey P, Teh CE, Tan T, Dagley LF, Yousef J, Yurick D, Khoury G, Preston SP, Arandjelovic P, Davidson KC, Williams LJ, Bader SM, Wang L, Bhandari R, Mackiewicz L, Dayton M, Clow W, Faulkner GJ, Gray DH, Einsiedel L, Purcell DFJ, Doerflinger M, Pellegrini M. Combination antiretroviral therapy and MCL-1 inhibition mitigate HTLV-1 infection in vivo. Cell. 2025;188(18):10.1016/j.cell.2025.06.023

Cagigas ML, Masedunskas A, Lin Y, Emery‐Corbin SJ, Yousef JM, Dagley LF, Olechnowicz S, Bowden R, Hayward R, Low G, Muirhead R, Brand‐Miller J, Fogeltholm M, Raben A, Demaria M, Fuller SJ, Fontana L. Short‐Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study. Aging Cell. 2025;24(8):10.1111/acel.70123

Kuo S, Spall S, Mohamed A, Dagley L, Cavero DA, Binos S, Chow K, Webb A, Hughes P. Quantitative Urine Proteomics Analysis Reveals Differences Between Kidney Transplant Rejection and Normal Pathology. American Journal of Transplantation. 2025;25(8):10.1016/j.ajt.2025.07.2198

Kuo SF-T, Spall S, Emery-Corbin SI, Mohamed A, Dite T, Chow K, Hughes P, Dagley LF, Webb AI. Quantitative Proteomic Analysis Unveils Protein Concentration Effects in Neat Urine Compared to Urine Extracellular Vesicles. Journal of Proteome Research. 2025;24(7):10.1021/acs.jproteome.5c00060

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