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About

I am the Proteomics Facility manager at The Walter and Eliza Hall Institute (WEHI). I have over 13 years’ experience in the application of novel mass spectrometry and proteomics technologies to address key research questions in the fields of infectious & inflammatory diseases and cancer. In 2009, I received a postgraduate scholarship from Multiple Sclerosis Research Australia to pursue my PhD with Prof. Tony Purcell (Monash). In 2010, I was awarded funding from multiple sources to continue my PhD research at the University of Toronto, Canada (with Prof. Andrew Emili). Here, I received world-class training in the use of mass spectrometry instruments and published collaborative research in top-tier proteomics journals. During my postdoctoral training at WEHI with Dr. Sandra Nicholson (2013-2015) and then A/Prof. Andrew Webb (2015-2020), I applied my comprehensive mass spectrometry training to address novel research questions, facilitating a range of productive research collaborations resulting in 8 first/co-first author publications in leading journals (including Nature Immunology). I am an active board member of the Australasian Proteomics Society (APS) executive committee and the Human Proteome Organisation (HUPO) Award committee.

Publications

Selected publications from Dr Laura Dagley

Dietrich MH, Chmielewski J, Chan L-J, Tan LL, Adair A, Lyons FMT, Gabriela M, Lopaticki S, Dite TA, Dagley LF, Pazzagli L, Gupta P, Kamil M, Vaughan AM, Rojrung R, Abraham A, Mazhari R, Longley RJ, Zeglinski K, Gouil Q, Mueller I, Fabb SA, Shandre-Mugan R, Pouton CW, Glukhova A, Shakeel S, Tham W-H. Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex. Science. 2025;:10.1126/science.ady0241

Kuo SF-T, Spall S, Emery-Corbin SI, Mohamed A, Dite T, Chow K, Hughes P, Dagley LF, Webb AI. Quantitative Proteomic Analysis Unveils Protein Concentration Effects in Neat Urine Compared to Urine Extracellular Vesicles. Journal of Proteome Research. 2025;24(7):10.1021/acs.jproteome.5c00060

Tan W, Park J, Venugopal H, Lou J, Dias PS, Baldoni PL, Moon K-W, Dite TA, Keenan CR, Gurzau AD, Lee J, Johanson TM, Leis A, Yousef J, Vaibhav V, Dagley LF, Ang C-S, Corso LD, Davidovich C, Vervoort SJ, Smyth GK, Blewitt ME, Allan RS, Hinde E, D’Arcy S, Ryu J-K, Shakeel S. MORC2 is a phosphorylation-dependent DNA compaction machine. Nature Communications. 2025;16(1):10.1038/s41467-025-60751-z

Marapana D, Cobbold SA, Pasternak M, Shami GJ, Ralph SA, Lopaticki S, Yousef J, Vaibhav V, Dagley LF, Komander D, Cowman AF. Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes. Scientific Reports. 2025;15(1):10.1038/s41598-025-05342-0

Cooney JP, Hirons A, Jansz N, Allison CC, Hickey P, Teh CE, Tan T, Dagley LF, Yousef J, Yurick D, Khoury G, Preston SP, Arandjelovic P, Davidson KC, Williams LJ, Bader SM, Wang L, Bhandari R, Mackiewicz L, Dayton M, Clow W, Faulkner GJ, Gray DH, Einsiedel L, Purcell DFJ, Doerflinger M, Pellegrini M. Combination antiretroviral therapy and MCL-1 inhibition mitigate HTLV-1 infection in vivo. Cell. 2025;:10.1016/j.cell.2025.06.023

Cagigas ML, Masedunskas A, Lin Y, Emery‐Corbin SJ, Yousef JM, Dagley LF, Olechnowicz S, Bowden R, Hayward R, Low G, Muirhead R, Brand‐Miller J, Fogeltholm M, Raben A, Demaria M, Fuller SJ, Fontana L. Short‐Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study. Aging Cell. 2025;:10.1111/acel.70123

Pascual R, Cheng J, De Smet AH, Capaldo BD, Tsai M, Kordafshari S, Vaillant F, Song X, Giner G, Milevskiy MJG, Jackling FC, Pal B, Dite T, Yousef J, Dagley LF, Smyth GK, Fu N, Lindeman GJ, Chen Y, Visvader JE. Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis. The EMBO Journal. 2025;44(11):10.1038/s44318-025-00422-3

Foot NJ, Dinh DT, Emery‐Corbin SJ, Yousef JM, Dagley LF, Russell DL. Comparative Analysis of the Progesterone Receptor Interactome in the Human Ovarian Granulosa Cell Line KGN and Other Female Reproductive Cells. Proteomics. 2025;25(13):10.1002/pmic.202400374

Callegari S, Kirk NS, Gan ZY, Dite T, Cobbold SA, Leis A, Dagley LF, Glukhova A, Komander D. Structure of human PINK1 at a mitochondrial TOM-VDAC array. Science. 2025;388(6744):10.1126/science.adu6445

Cai T, Emery-Corbin SJ, McCafferty C, Van Den Helm S, Letunica N, Barton R, Attard C, Horton S, Bottrell S, Schultz B, MacLaren G, Chiletti R, Best D, Johansen A, Newall F, Butt W, d’Udekem Y, Dagley LF, Yousef JM, Monagle P, Ignjatovic V. Characterization of Protein Binding on an Extracorporeal Membrane Oxygenation (ECMO) Circuit Following the Priming Procedure. ASAIO Journal. 2025;71(4):10.1097/mat.0000000000002273

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