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- A new regulator of 'stemness' to create dendritic cell factories for immunotherapy
- Advanced imaging interrogation of pathogen induced NETosis
- Cancer driver deserts
- Cryo-electron microscopy of Wnt signalling complexes
- Deciphering the heterogeneity of breast cancer at the epigenetic and genetic levels
- Developing drugs to block malaria transmission
- Developing new computational tools for CRISPR genomics to advance cancer research
- Developing novel antibody-based methods for regulating apoptotic cell death
- Discovering novel paradigms to cure viral and bacterial infections
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Do membrane forces govern assembly of the deadly apoptotic pore?
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- E3 ubiquitin ligases in neurodegeneration, autoinflammation and cancer
- Engineering improved CAR-T cell therapies
- Epigenetic biomarkers of tuberculosis infection
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- Genomic rearrangement detection with third generation sequencing technology
- How does DNA damage shape disease susceptibility over a lifetime?
- How does DNA hypermutation shape the development of solid tumours?
- How platelets prevent neonatal stroke
- Human lung protective immunity to tuberculosis
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigating the role of dysregulated Tom40 in neurodegeneration
- Investigating the role of mutant p53 in cancer
- Lupus: proteasome inhibitors and inflammation
- Machine learning methods for somatic genome rearrangement detection
- Malaria: going bananas for sex
- Measurements of malaria parasite and erythrocyte membrane interactions using cutting-edge microscopy
- Measuring susceptibility of cancer cells to BH3-mimetics
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Mutational signatures of structural variation
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Revealing the epigenetic origins of immune disease
- Reversing antimalarial resistance in human malaria parasites
- Structural and functional analysis of DNA repair complexes
- Targeting human infective coronaviruses using alpaca antibodies
- Towards targeting altered glial biology in high-grade brain cancers
- Uncovering the real impact of persistent malaria infections
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding how malaria parasites sabotage acquisition of immunity
- Understanding malaria infection dynamics
- Understanding the mechanism of type I cytokine receptor activation
- Unveiling the heterogeneity of small cell lung cancer
- Using alpaca antibodies to understand malaria invasion and transmission
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to cross the blood brain barrier for drug delivery
- Using structural biology to understand programmed cell death
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Seth Masters-Lab team
Researcher:
Team
Sophia Davidson, Postdoctoral Fellow, BBiomedSc(Hons) Newcastle PhD London
Key publication:
Davidson S, McCabe TM, Crotta S, Gad HH, Hessel EM, Beinke S, Hartmann R, Wack A.IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment. EMBO Mol Med. 2016 Sep 1;8(9):1099-112. PMID: 27520969
Katja Hrovat-Schaale, Postdoctoral Fellow, PhD University of Ljubljana
Elisabeth Mulazzani, Postdoctoral Fellow, MD PhD Medical University of Vienna
Annemarie Steiner, Postdoctoral Fellow, BSc Greifswald MSc Jena
Klara Kong, Research Assistant, BBms(Hons) MCRI
Pawat Laohamonthonkul, Research Assistant, BSc(Hons) Queensland
Brooke McDonald, Research Assistant, BSc Monash
June Sun, Research Assistant, BSc(Hons) UNSW
Cassandra Harapas, PhD Student, BSc(Hons) Melbourne
Anja Kopp, PhD Student, BSc Berlin
Thomas Reygaerts, PhD Student, MD Beligium
Sophie Collard, Masters Student, BSc Melbourne
Former lab members
Paul Baker Current position: Postdoctoral Fellow, National Institute of Allergy and Infectious Diseases
Katherine Balka Current position: PhD student, Monash University
Dale Calleja Current position: PhD student, WEHI
Dominic de Nardo Current position: Group Leader, Monash University
Damian D’Silva Current position: Research Assistant, WEHI
Motti Gerlic Current position: Laboratory Head, Tel Aviv University
Jacob Jackson Current position: Research Assistant, WEHI
Man Lyang Kim Current position: Postdoctoral Fellow, WEHI
Jonas Moecking Current position: Postdoctoral Fellow, University of Bonn
Fiona Moghaddas Current position: Immunology and Allergy Registrar, Royal Melbourne Hospital
Hazel Tye Current position: Postdoctoral Fellow, Hudson Institute
Alan Yu Current position: Laboratory Head, Florey Institute of Neuroscience
Collaborators
We collaborate with many external research groups, including:
Professor Luke O’Neill, Trinity College Dublin; Drs Daniel Kastner, Ivona Aksentijevich and Raphaela Goldbach-Masnky, National Institutes of Health; Professors Eicke Latz and Matthias Geyer, University of Bonn; Dr Bruno Reversade, A*Star; Associate Professor Andrew Murphy, Baker IDI; Professor Mike Rogers, Garvan Institute; Associate Professor Richard Ferrero, Monash University; Drs Kate Schroder and Kate Stacey, University of Queensland
Super Content:
Researchers have uncovered clues in the immune system that reveal how the balance of ‘good’ gut bacteria is maintained.
The information could help in the prevention and treatment of inflammatory bowel disease (IBD).