Dr Isabelle Lucet

Dr Isabelle Lucet

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Isabelle Lucet

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Dr
Isabelle
Lucet

BSc(Hons) Nantes PhD Angers

Laboratory Head

Division:

My laboratory investigates how defects in signalling molecules called protein kinases cause major human diseases. In a normal cell, protein kinases control cell behaviour by regulating many fundamental processes within the cell. But when protein kinases are out of control, normal cell development goes awry and can lead to cancers and inflammatory disorders.

We study the molecular structure of protein kinases to fully unravel their mechanism of action. We aim to identify new kinase-controlled regulatory pathways and develop novel therapeutic strategies for the treatment of blood cancers, inflammatory disorders and infectious diseases.

Research interest

My laboratory has a long-standing interest in providing fundamental insights into the molecular structure of key protein kinases that play prominent role in human diseases. Our ultimate goal is to develop rationally designed therapeutic strategies to counter various cancers, inflammatory diseases and infectious diseases.

We are particularly interested in:

  • Developing strategies to gain insights into the structure, function and biology of a group of kinase-like proteins, called Pseudokinases, that have recently emerged as crucial regulators of signalling transduction, acting as modulators of the catalytic activities of bona fide kinases or as scaffolding proteins that promote the assembly of signaling complexes.
  • Exploring the druggability of the Plasmodium falciparum kinome in order to identify anti-malarials with novel modes of action.

We employ a multidisciplinary approach that includes:

  • Kinase biochemistry

  • Structural biology

  • Medicinal chemistry

  • Chemical biology

  • High-throughput screening

These are allowing us to identify new kinase-controlled regulatory pathways and develop novel chemical compounds for future drug development initiatives.

Dr Isabelle Lucet and Dr Onisha Patel

Researchers have produced the first 3D map of a molecular structure called SgK223, known to play a critical role in the development and spread of aggressive breast, colon and pancreatic cancers.

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