Dr Andrew Webb

Dr Andrew Webb

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Dr Andrew Webb in the lab

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Dr
Andrew
Webb

BSc (MSc) Monash PhD Monash

Acting Division Head

Our research applies the latest proteomics methods to understand how changes in proteins in our body influence health and disease.

In particular we are interested in developing new techniques to advance basic laboratory research and clinical studies. Ongoing research studies include:

  • Understanding the cell signalling pathways contributing to inflammatory conditions such as rheumatoid arthritis.
  • Developing a blood test to predict which children are at risk of developing rheumatic fever.
  • Detecting a test for detecting stomach cancer at early, more treatable stages.

Research interest 

We collaborate widely with scientists and clinicians to advanced proteomics technologies to identify and quantify proteins in cells and biofluids.

Our laboratory covers diverse range of areas that can be categorised into five key focus areas:

  • Interactions: Elucidation of protein-protein and protein-drug interactions
  • Protein dynamics: Investigating the mechanisms of protein function
  • Signalling: Investigation of signalling pathways (using phosphoproteomics and ubiquitin enrichment strategies)
  • Biomarkers: Identification of prognostic and diagnostic biomarkers of disease in biofluids
  • Epigenetics: Quantification of intact histones and their modifications in developmental and disease models
Animation still showing X inactivation

WEHI.TV animation: X inactivation is a vital process that occurs in all DNA-containing cells of the female body. It is also an important research model and tool for studying epigenetics.

We have discovered that cartilage plays an active role in the destruction and remodelling of joints seen in rheumatoid arthritis.