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- A multi-pronged approach to targeting myeloproliferative neoplasms
- A new paradigm of machine learning-based structural variant detection
- A whole lot of junk or a treasure trove of discovery?
- Advanced imaging interrogation of pathogen induced NETosis
- Analysing the metabolic interactions in brain cancer
- Atopic dermatitis causes and treatments
- Boosting the efficacy of immunotherapy in lung cancer
- Building a cell history recorder using synthetic biology for longitudinal patient monitoring
- Characterisation of malaria parasite proteins exported into infected liver cells
- Deciphering the heterogeneity of the tissue microenvironment by multiplexed 3D imaging
- Defining the mechanisms of thymic involution and regeneration
- Delineating the molecular and cellular origins of liver cancer to identify therapeutic targets
- Developing computational methods for spatial transcriptomics data
- Developing drugs to block malaria transmission
- Developing models for prevention of hereditary ovarian cancer
- Developing statistical frameworks for analysing next generation sequencing data
- Development and mechanism of action of novel antimalarials
- Development of novel RNA sequencing protocols for gene expression analysis
- Discoveries in red blood cell production and function
- Discovering epigenetic silencing mechanisms in female stem cells
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Dissecting mechanisms of cytokine signalling
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- Epigenetic biomarkers of tuberculosis infection
- Epigenetics – genome wide multiplexed single-cell CUT&Tag assay development
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Exploiting the cell death pathway to fight Schistosomiasis
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- How do nutrition interventions and interruption of malaria infection influence development of immunity in sub-Saharan African children?
- Human lung protective immunity to tuberculosis
- Improving therapy in glioblastoma multiforme by activating complimentary programmed cell death pathways
- Innovating novel diagnostic tools for infectious disease control
- Integrative analysis of single cell RNAseq and ATAC-seq data
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigation of a novel cell death protein
- Malaria: going bananas for sex
- Mapping spatial variation in gene and transcript expression across tissues
- Mechanisms of Wnt secretion and transport
- Multi-modal computational investigation of single-cell communication in metastatic cancer
- Nanoparticle delivery of antibody mRNA into cells to treat liver diseases
- Naturally acquired immune response to malaria parasites
- Organoid-based discovery of new drug combinations for bowel cancer
- Organoid-based precision medicine approaches for oral cancer
- Removal of tissue contaminations from RNA-seq data
- Reversing antimalarial resistance in human malaria parasites
- Role of glycosylation in malaria parasite infection of liver cells, red blood cells and mosquitoes
- Screening for novel genetic causes of primary immunodeficiency
- Single-cell ATAC CRISPR screening – Illuminate chromatin accessibility changes in genome wide CRISPR screens
- Spatial single-cell CRISPR screening – All in one screen: Where? Who? What?
- Statistical analysis of single-cell multi-omics data
- Structural and functional analysis of epigenetic multi-protein complexes in genome regulation
- Structural basing for Wnt acylation
- Structure, dynamics and impact of extra-chromosomal DNA in cancer
- Targeted deletion of disease-causing T cells
- Targeting cell death pathways in tissue Tregs to treat inflammatory diseases
- The cellular and molecular calculation of life and death in lymphocyte regulation
- The role of hypoxia in cell death and inflammation
- The role of ribosylation in co-ordinating cell death and inflammation
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding cellular-cross talk within a tumour microenvironment
- Understanding the genetics of neutrophil maturation
- Understanding the roles of E3 ubiquitin ligases in health and disease
- Unveiling the heterogeneity of small cell lung cancer
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to understand malaria invasion and transmission
- Using structural biology to understand programmed cell death
- Validation and application of serological markers of previous exposure to malaria
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Andreas Strasser - Lab team
Researcher:
All students and postdocs in my group have clearly demarcated projects. This helps maximise the areas of research that we can tackle. When work within an area needs to be accelerated, help is provided by other members from the lab, particularly research assistants.
We collaborate closely with the Gray and Herold laboratories, both of which are led by former postdocs from my lab, as well as with all other laboratories within the Molecular Genetics of Cancer division. My lab also has close collaborations with many laboratories from other divisions at the Institute, and many laboratories elsewhere in Australia and overseas.
Team
Lorraine O’Reilly, Senior Scientist, BSc Glasgow PhD London
Project: Investigating the role of NF-kB1 as a tumour suppressor in gastric cancer
Project: The use of monoclonal antibodies to isolate novel proteins involved in cellular life or death decisions
Project: Testing the potential of the NF-kB family member c-Rel as a therapeutic target in multiple common autoimmune diseases
Key publication: O'Reilly LA, Putoczki TL, Mielke LA, Low JT, Lin A, Preaudet A, Herold MJ, Yaprianto K, Tai L, Kueh A, Pacini G, Ferrero RL, Gugasyan R, Hu Y, Christie M, Wilcox S, Grumont R, Griffin MDW, O'Connor L, Smyth GK, Ernst M, Waring P, Gerondakis S, Strasser A. Loss of NF-kB1 causes gastric cancer with aberrant inflammation and expression of immune checkpoint regulators in a STAT-1-dependent manner. Immunity. 2018 Mar 20;48(3):570-583.e8. PMID: 29562203
Gemma Kelly, Senior Postdoctoral Fellow, BSc (Hons) Durham PhD Birmingham
Project: Investigating the role of mutant p53 and MCL-1 in the sustained growth of MYC driven lymphomas and strategies for targeted therapy
Project: Investigating the function of the Epstein-Barr virus-encoded viral BCL-2 homologue, BHRF1
Key publication: Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, Valente LJ, Robati M, Tai L, Fairlie WD, Lee EF, Lindstrom MS, Wiman KG, Huang DC, Bouillet P, Rowe M, Rickinson AB, Herold MJ, Strasser A. Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53. Genes Dev. 2014 Jan 1;28(1):58-70. PMID: 24395247
Kerstin Brinkmann, Postdoctoral Fellow, BBiolSc(Hons) Cologne PhD Cologne
Project: The role of MCL-1 in protecting haematopoietic stem and progenitor cells from cancer therapeutics
Project: The molecular control of MCL-1 expression
Key publication: Brinkmann K, Grabow S, Hyland CD, Teh CE, Alexander WS, Herold MJ, Strasser A. The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice. Cell Death Differ. 2017 Dec;24(12):2032-2043. PMID: 28800129
Sarah Diepstraten, Postdoctoral Fellow, BSc(Hons) LaTrobe PhD LaTrobe
Project: Exploring the role of the pro-survival proteins Bcl-w and BFL1 in human cancers
Project: MCL-1 inhibitors as a targeted therapy for MYC-driven lymphomas.
Ana Janic, Postdoctoral Fellow, BSc Belgrade PhD Barcelona
Project: Identification of the critical p53 tumour suppression mechanisms by using in vivo shRNA library screening
Key publication: Janic A, Valente LJ, Wakefield MJ, Di Stefano L, Milla L, Wilcox S, Yang H, Tai L, Vandenberg CJ, Kueh AJ, Mizutani S, Brennan MS, Schenk RL, Lindqvist LM, Papenfuss AT, O’Connor L, Strasser A, Herold MJ. Sensitised in vivo shRNA screens identify effectors of p53-mediated tumour suppression and reveal a critical role of DNA repair. Nature Medicine. 2018 (in press).
Francine Ke, Postdoctoral Fellow, BSc (Hons) PhD Melbourne
Project: Understanding the role of cell death pathways in embryonic development
Project: Pharmacological inhibition of MCL-1 and BCL-XL to treat human medulloblastoma
Key publication: Ke F, Vanyai H, Cowan A, Whitehead L, Delbridge AR, Grabow S, Czabotar P, Voss AK, Strasser A. Rare instances of embryogenesis and adult life in the absence of the intrinsic apoptosis effectors BAX, BAK and BOK. Cell. 2018 (in press)
Shinsuke Mizutani, Postdoctoral Fellow, MD, PhD Kyoto
Project: Whole genome CRISPR screen to identify novel mechanisms of tumour suppression
Key publication: Mizutani S, Yoshida T, Zhao X, Nimer SD, Taniwaki M and Okuda T: Loss of Runx1/AML1 arginine-methylation impairs peripheral T cell homeostasis. Br J Haematol. 2015 Sep;170(6):859-73. PMID: 26010396
Melanie Heinlein, PhD Student, BSc MSc Albert-Ludwigs Freiburg
Project: Novel regulators of immunological tolerance
Key publication: Weber A, Heinlein M, Dengjel J, Alber C, Singh PK, Häcker G. The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. EMBO Rep. 2016 May;17(5):724-38.PMID: 27013495
Lizzie Lieschke, PhD Student, BSc(Hons) Melbourne
Project: Investigating the contributions of cell death, cell cycle arrest and cell senescence to p53 mediated tumor suppression
Jun Ting Low, PhD Student, BBiomedSc (Hons) Melbourne
Project: Understanding the Role of NF-kB1 in Gastric Cancer
Key publication: Low JT, Hughes P, Lin A, Siebenlist U, Jain R, Yaprianto K, Gray DH, Gerondakis S, Strasser A, O'Reilly LA. Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice. Immunol Cell Biol. 2016 Jan;94(1):66-78. PMID: 26084385
Zilu Wang, PhD Student, MD, MSc, Nanjing Medical University
Project: Identification of the mechanisms of APR-246 induced killing of tumour cells.
Catherine Chang, Research Assistant, BBiomedSc Melbourne
Super Content:
Researchers have genetically engineered a laboratory model for testing the effectiveness of new anti-cancer drugs called MCL-1 inhibitors.
Institute researchers have led a study suggesting that abnormalities in cell death (apoptosis) could be linked to common birth defects including spina bifida.
Support from Cancer Council NSW is enabling our researchers to develop ways to better detect the early stages of stomach cancer.
Cell death researcher Associate Professor James Murphy and cancer researcher Dr Gemma Kelly are joint winners of the 2017 Burnet Prize, the Institute's top science prize.