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- Alistair Brown
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- A multi-pronged approach to targeting myeloproliferative neoplasms
- A new paradigm of machine learning-based structural variant detection
- A whole lot of junk or a treasure trove of discovery?
- Advanced imaging interrogation of pathogen induced NETosis
- Analysing the metabolic interactions in brain cancer
- Atopic dermatitis causes and treatments
- Boosting the efficacy of immunotherapy in lung cancer
- Building a cell history recorder using synthetic biology for longitudinal patient monitoring
- Characterisation of malaria parasite proteins exported into infected liver cells
- Deciphering the heterogeneity of the tissue microenvironment by multiplexed 3D imaging
- Defining the mechanisms of thymic involution and regeneration
- Delineating the molecular and cellular origins of liver cancer to identify therapeutic targets
- Developing computational methods for spatial transcriptomics data
- Developing drugs to block malaria transmission
- Developing models for prevention of hereditary ovarian cancer
- Developing statistical frameworks for analysing next generation sequencing data
- Development and mechanism of action of novel antimalarials
- Development of novel RNA sequencing protocols for gene expression analysis
- Discoveries in red blood cell production and function
- Discovering epigenetic silencing mechanisms in female stem cells
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Dissecting mechanisms of cytokine signalling
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- Epigenetic biomarkers of tuberculosis infection
- Epigenetics – genome wide multiplexed single-cell CUT&Tag assay development
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Exploiting the cell death pathway to fight Schistosomiasis
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- How do nutrition interventions and interruption of malaria infection influence development of immunity in sub-Saharan African children?
- Human lung protective immunity to tuberculosis
- Improving therapy in glioblastoma multiforme by activating complimentary programmed cell death pathways
- Innovating novel diagnostic tools for infectious disease control
- Integrative analysis of single cell RNAseq and ATAC-seq data
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigation of a novel cell death protein
- Malaria: going bananas for sex
- Mapping spatial variation in gene and transcript expression across tissues
- Mechanisms of Wnt secretion and transport
- Multi-modal computational investigation of single-cell communication in metastatic cancer
- Nanoparticle delivery of antibody mRNA into cells to treat liver diseases
- Naturally acquired immune response to malaria parasites
- Organoid-based discovery of new drug combinations for bowel cancer
- Organoid-based precision medicine approaches for oral cancer
- Removal of tissue contaminations from RNA-seq data
- Reversing antimalarial resistance in human malaria parasites
- Role of glycosylation in malaria parasite infection of liver cells, red blood cells and mosquitoes
- Screening for novel genetic causes of primary immunodeficiency
- Single-cell ATAC CRISPR screening – Illuminate chromatin accessibility changes in genome wide CRISPR screens
- Spatial single-cell CRISPR screening – All in one screen: Where? Who? What?
- Statistical analysis of single-cell multi-omics data
- Structural and functional analysis of epigenetic multi-protein complexes in genome regulation
- Structural basing for Wnt acylation
- Structure, dynamics and impact of extra-chromosomal DNA in cancer
- Targeted deletion of disease-causing T cells
- Targeting cell death pathways in tissue Tregs to treat inflammatory diseases
- The cellular and molecular calculation of life and death in lymphocyte regulation
- The role of hypoxia in cell death and inflammation
- The role of ribosylation in co-ordinating cell death and inflammation
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding cellular-cross talk within a tumour microenvironment
- Understanding the genetics of neutrophil maturation
- Understanding the roles of E3 ubiquitin ligases in health and disease
- Unveiling the heterogeneity of small cell lung cancer
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to understand malaria invasion and transmission
- Using structural biology to understand programmed cell death
- Validation and application of serological markers of previous exposure to malaria
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Alan Cowman-Lab team
Researcher:
We are an interdisciplinary team, combining expertise in cell biology, imaging, structural studies and biological chemistry. We collaborate with scientific institutions in Australia and internationally, including Monash University, Janelia Farm, Imperial College London, and pharmaceutical companies such as Merck & Co., Inc.
We believe that together we can combat malaria.
Lab team
Stella Kyvetos, Division Coordinator, Dip AppSc (Medical Laboratory) RMIT
Julie Healer, Senior Scientist, BSc (Hons) Glasgow MPhil London PhD Edinburgh
Project: Insectary management and vaccine development
Tony Hodder, Senior Scientist, BSc (Hons) PhD Monash
Project: Biochemical studies on the parasite invasion complex
Paola Favuzza, Senior Postdoctoral Fellow, BSc MSc Palermo PhD Basel
Project: In vitro and in vivo studies for drug screening and development
Stephen Scally, Senior Postdoctoral Fellow, BBiomedSci BSc (Hons) Melbourne, PhD Monash
Project: Structural and functional studies of the parasite invasion complex
Tony Triglia, Senior Postdoctoral Fellow, BSc (Hons) MSc Melbourne
Project: Genome editing and the function of the parasite invasion complex
Wilson Wong, Senior Postdoctoral Fellow, BBiomed Griffith BBiomed (Hons) PhD Monash
Project: Cryo-EM and structural studies on the parasite invasion complex
Janni Boding Christensen, Postdoctoral Fellow, BSc Copenhagen MSc PhD Melbourne
Project: Drug discovery
Danushka Marapana, Postdoctoral Fellow, BSc (Hons) PhD Melbourne
Project: Parasite protein export into the host cell
Michał Pasternak, Sir Henry Wellcome Postdoctoral Fellow (joint with Professor Jake Baum at Imperial College London), BSc MSc Warsaw, PhD Cambridge
Project: Advanced light microscopy and cryo-EM tomography
Jenny Thompson, Research Assistant, BSc MSc Melbourne
Project: Drug discovery and resistance studies
Melissa Hobbs, Laboratory Technician, BSc Monash, Dip. Animal Tech. Box Hill TAFE
Bethany Davey, Postgraduate Student, BBiomedSci/BMedChem La Trobe BSci (Hons) Melbourne
Project: Investigating new antimalarial compounds
Benjamin Seager, Postgraduate Student, BBmed (Hons) Melbourne
Project: Biochemical and structural studies of parasite invasion proteins
Kitsanapong Reaksudsan, Postgraduate Student, MSc Chiang Mai
Project: Studies on parasite life cycle during transmission
Julie Verhoef, Visiting Master’s Student, BSc Nijmigen
Project: Superresolution light microscopy and live imaging
Super Content:
Researchers have developed a novel class of antimalarial compounds that can effectively kill malaria parasites.
Light microscopy at the Institute's Centre for Dynamic Imaging is giving researchers new insights into the behaviour of a deadly malaria-causing parasite.