Malaria is an infectious disease caused by Plasmodium parasites. Invasion of human red blood cells by the parasite is a complex multistep process that involves interactions of parasite proteins with host receptors that leads to internalization of the parasite. We aim to understand the function of these parasite proteins that lead to successful invasion. In particular, we aim to understand the role of the PCRCR complex (Scally et al, Nat Micro 2022 7(12):2039) in parasite invasion in both Plasmodium falciparum and Plasmodium vivax. To aid this, we have developed monoclonal antibodies and nanobodies to essential invasion proteins that will be utilised as critical reagents to dissect function and structure. Depending on the student’s interests, this project will use a variety of techniques, including molecular biology (CRISPR gene editing), parasitology, immunology, biochemistry and structural biology. Findings from this project will aid in the design of an effective malaria vaccine.
