The Zeiss Lightsheet Z.1 microscope offers scientists the opportunity to image large 3D objects that would be impossible or far too time consuming to analyse on traditional microscopes.

With the Zeiss Z.1 system scientists can utilise a developing technology to acquire large volumetric data sets of 3D structures.

Unlike traditional widefield and confocal microscopes, the Z.1 utilises a ‘sheet’ of light shone through the sample and the image is then detected perpendicular to the lightsheet.

The Z.1 system is intended for fluorescently labelled samples (both endogenous and antibody labelled). It also has the capability of acquiring a bright-field reference image.

The system comes with a number of specific imaging chambers, however sample preparation and mounting are very flexible. This allows for a wide range of sample types to be imaged.

This microscope provides scientists with the ability to image large ‘cleared’ samples to a much greater depth and at faster speeds than has previously been possible.

The Zeiss Lattice Lightsheet is the first pre-commercial system for lattice light sheet microscopy, enabling a greater number of researchers to access the current state of the art technology for live-cell imaging.

Lattice light sheet microscopy is at the cutting edge of technology for live cell imaging due to its combination of high spatial and temporal resolution whilst simultaneously being incredibly gentle on the samples that are imaged.

This technology is now available as a pre-commercial platform offering researchers experimental flexibility in an easy to use system. The technology offers the ability to interrogate complex biological dynamics in 4D with high resolution over long time periods.

Lattice light sheet microscopy is the current state of the art for live cell imaging, enabling unprecedented 4D imaging capabilities.

Imaging biology in 4D has been a significant challenge in recent decades. The light used for imaging usually damages biological samples, making long term time-lapse microscopy extremely difficult.

Lattice light sheet microscopy is at the cutting edge of technology for live cell imaging because it is incredibly gentle on samples, allowing high resolution imaging over time.

This lattice light sheet was custom-built by staff at the Centre for Dynamic Imaging and was the first of its kind in Australia.