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T Cell Interaction Lab

Laboratory Head
7 members

About the lab

Our immune system consists of dedicated immune cells that collaborate to protect against infection and disease. T cells are orchestrators of immune responses and require multiple interactions with distinct partner cells to steer their function. Our laboratory observes and dissects these interactions with unprecedented precision to understand how cellular interactions can be harnessed to direct the outcome of immune responses.

We aim to identify how T cell interactions:

  • determine the clearance of pathogens (such as influenza and SARS-CoV-2) or cancer cells
  • are tailored between infections and go awry in asthma, rheumatoid arthritis and lupus, and during immune-related adverse immunotherapy events; and
  • understand how memory cells are generated and maintained for long-lived vaccine protection.

Our mission

Our goal is to apply these discoveries to enable the design of new vaccine strategies and drive the generation of novel therapies to overcome cancer, asthma and autoimmunity.

Impact

Research from our lab has highlighted the importance of precise T cell location and their cell contacts in directing and modulating these responses.
Discovery: T cell fates are programmed within distinct lymph node niches
Discovery: Development of vaccine platform that specifically enhances memory formation
Discovery: Identified new niche where T cells reside long-term
Discovery: Identified flexible transcriptional pathogen-specific programs
Tech development: Generation of the first chemokine reporter mouse
Tech development: Tissue clearing of intact organs and analysis pipeline for analysis of cells in 3D space
Tech development: New microfluidics chamber to assess cell migration decisions

Lab research projects

Lab team

We work closely with the other members of the Immunology division and WEHI’s Centre for Dynamic Imaging, Genomics facility and Bioinformatics.

We seek driven students and scientists who are open to new technologies and interested in dissecting the influence of cell migration and interactions on immune outcomes.

7 members
Research Officer
Bailey Williams
Research Assistant
Lennard Dalit
PhD Student
Raymond Qin
PhD Student
Research Officer
Interested in supporting our research?

Your support will help WEHI’s researchers make discoveries and find treatments to ensure healthier, longer lives for you and your loved ones.

Contact our friendly team to find out how you can help.