Exploring the role of protein glycosylation in myelofibrosis

• PhD
• Graduate Research Masters
• Honours

The aim of this project is to better understand the role that protein glycosylation plays in the progression of myelofibrosis (MF) and how it might be targeted to deliver new drugs for this incurable disease. Myeloproliferative neoplasms are a group of rare blood cancers that arise from mutations in the blood-forming cells that reside within the bone marrow. MF is the most severe of these diseases and it is currently managed with non-curative drugs that have serious side-effects. This project will use tools developed in my laboratory to examine how targeting different cellular glycosylation pathways might impact the progression of MF. This project can be tailored to someone with a strong background in either biochemistry, cell biology or chemistry.

The Goddard-Borger laboratory studies the glycobiology of human diseases and works towards the development of new therapeutics using techniques in chemical, structural and molecular biology. Our research is highly collaborative, leading us to work closely with leading scientists at the institute, across Australia and around the world. This provides an excellent interdisciplinary training environment for students and postdoctoral researchers as well as opportunities to build valuable networks within the industry.