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Themes / Divisions

About

We use genetics and genomics tools to probe physiological gene function and to discover the molecular regulators controlling blood cell production and activity. Through collaborations with other laboratories, we apply a multidisciplinary approach to dissect the biology, biochemistry, molecular biology and genetics of regulators of blood cells.

Publications

Selected publications from Prof Warren Alexander

Stonehouse OJ, Biben C, Weber TS, Garnham A, Fennell KA, Farley A, Terreaux AF, Alexander WS, Dawson MA, Naik SH, Taoudi S. Clonal analysis of fetal hematopoietic stem/progenitor cells reveals how post-transplantation capabilities are distributed. Stem Cell Reports. 2024;19(8):10.1016/j.stemcr.2024.07.003

Behrens K, Kauppi M, Viney EM, Kueh AJ, Hyland CD, Willson TA, Salleh L, de Graaf CA, Babon JJ, Herold MJ, Nicola NA, Alexander WS. Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease. Leukemia. 2024;38(6):10.1038/s41375-024-02219-5

Bergamasco MI, Ranathunga N, Abeysekera W, Li-Wai-Suen CSN, Garnham AL, Willis SN, McRae HM, Yang Y, D’Amico A, Di Rago L, Wilcox S, Nutt SL, Alexander WS, Smyth GK, Voss AK, Thomas T. The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function. Stem Cell Reports. 2024;19(4):10.1016/j.stemcr.2024.02.005

Behrens K, Brajanovski N, Xu Z, Viney EM, DiRago L, Hediyeh-Zadeh S, Davis MJ, Pearson RB, Sanij E, Alexander WS, Ng AP. ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemia. Science Advances. 2024;10(10):10.1126/sciadv.adj8803

Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang J-G, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NPD, Linossi EM, Burns CJ, Carotta S, Gray DHD, Seillet C, Hutchinson DS, Belz GT, Webb AI, Alexander WS, Li SS, Bullock AN, Babon JJ, Smyth MJ, Nicholson SE, Huntington ND. Author Correction: CIS is a potent checkpoint in NK cell–mediated tumor immunity. Nature Immunology. 2024;25(2):10.1038/s41590-023-01714-8

Bennett C, Jackson VE, Pettikiriarachchi A, Hayman T, Schaeper U, Moir-Meyer G, Fielding K, Ataide R, Clucas D, Baldi A, Garnham AL, Li-Wai-Suen CSN, Loughran SJ, Baxter EJ, Green AR, Alexander WS, Bahlo M, Burbury K, Ng AP, Pasricha S-R. Iron homeostasis governs erythroid phenotype in polycythemia vera. Blood. 2023;141(26):10.1182/blood.2022016779

Abdulla HD, Alserihi R, Flensburg C, Abeysekera W, Luo M-X, Gray DHD, Liu X, Smyth GK, Alexander WS, Majewski IJ, McCormack MP. Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition. Journal of Experimental Medicine. 2023;220(6):10.1084/jem.20212383

Doggett K, Keating N, Dehkhoda F, Bidgood GM, Meza Guzman LG, Leong E, Kueh A, Nicola NA, Kershaw NJ, Babon JJ, Alexander WS, Nicholson SE. The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo. Cytokine. 2023;165:10.1016/j.cyto.2023.156167

Au AE, Corbin J, Lebois M, Gangatirkar P, Yassinson F, Hyslop SR, Cannon P, Mason KD, Li-Wai-Suen CSN, Garnham AL, Moujalled D, Cimmino L, Alexander WS, Josefsson EC. Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels. Blood Advances. 2023;7(8):10.1182/bloodadvances.2022007849

Li K, Guzman LGM, Whitehead L, Leong E, Kueh A, Alexander WS, Kershaw NJ, Babon JJ, Doggett K, Nicholson SE. SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine. Bioscience Reports. 2022;42(12):10.1042/bsr20221683

Lab research projects

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