Brain Cancer Research Lab

We use a variety of spatial technologies to investigate the tumour microenvironment, including transcriptomics and metabolomics, to better understand the architecture of glioma.

Venture Grant funding: ‘Brightest cancer researchers’: WEHI teams awarded new funding grants

Team members: Jurgen Kriel, Joel Moffet, Lutz Freytag, Tianyao Lu

The lab uses a variety of genomic techniques with a strong focus on technologies that can resolve cellular complexity, such as single cell transcriptomics, spatial transcriptomics, Nanostring and MIBIscope.

Project resource: GLIMMER funding

Team members: Oluwaseun Fatunla, Montana Spiteri

Our lab is developing a strong foundation of pre-clinical models to study glioma development in immune-competent systems with an intact blood brain barrier.

Team member: Shannon Oliver

Our lab generates patient derived models (eg. neuropshere, and patient derived xenografts) to test new anti-cancer agents and combinations.

Team members: Adam Valkovic, Zac Moore, Montana Spiteri

Our lab is intimately involved with the Australia-first perioperative clinical trial program for brain cancer, and is leading the translational research for these studies.

Team member: Rob Tobler

Correct brain development is critically dependent on genetic and environmental cues and signals. When the process goes wrong it can result in malformations of cortical development and cause severe epilepsy, often requiring surgical resection of the affected brain regions. Exploiting technologies that allow the characterization of individual cells, Saskia, and her collaborators at MCRI are investigating how epilepsy arises.