Unlocking the Writers of the Ubiquitin Code:Functional Genomics to Expand E3 Ligase Biology and Discover New Opportunities for Disease Intervention

• PhD
• Honours

The Feltham Lab is seeking a PhD student to explore how E3 ligases, the “writers” of the ubiquitin code, control protein fate and contribute to disease. Using cutting-edge functional genomics, including CRISPR screening, you will study E3 ligases to uncover novel biology and therapeutic opportunities.

The project combines genome engineering, molecular biology, and cell-based degradation assays to map signalling pathways and identify new targets for drug discovery. This is a unique opportunity to work at the interface of fundamental biology and translational research, with access to world-class facilities and collaborative networks.

The Feltham Lab investigates the ubiquitin system and its role in disease with a focus on harnessing E3 ligases for therapeutic discovery. We combine molecular biology, genetic engineering, chemical biology and targeted protein degradation technologies to uncover how E3 ligases can be exploited to treat disease.

Our research spans fundamental discovery through to translational applications, including collaboration with industry partners. The lab offers a dynamic, collaborative, and supportive environment, with access to cutting-edge technologies including CRISPR screening platforms, proteomics, cell-based degrader systems, and a focus on inflammatory signalling and cancer.

Our team is committed to scientific excellence, innovation, and mentoring the next generation of scientists to develop the skills needed for both academic and industry careers.