Wai-Hong Tham-Publications

Wai-Hong Tham-Publications

Selected publications

  1. Gruszczyk J, Lim NT, Arnott A, He WQ, Nguitragool W, Roobsoong W, Mok YF, Murphy JM, Smith KR, Lee S, Bahlo M, Mueller I, Barry AE, Tham WH. Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold  for alternate receptor engagement. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E191-200. doi: 10.1073/pnas.1516512113. Epub 2015 Dec 29. PubMed PMID:  26715754; PubMed Central PMCID: PMC4720341.   
  2. Kennedy AT, Schmidt CQ, Thompson JK, Weiss GE, Taechalertpaisarn T, Gilson PR, Barlow PN, Crabb BS, Cowman AF, Tham WH. Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection. J Immunol. 2016 Feb 1;196(3):1239-48. doi: 10.4049/jimmunol.1501581. Epub 2015 Dec  23. PubMed PMID: 26700768.   
  3. Tham WH, Lim NT, Weiss GE, Lopaticki S, Ansell BR, Bird M, Lucet I, Dorin-Semblat D, Doerig C, Gilson PR, Crabb BS, Cowman AF. Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes. PLoS Pathog. 2015 Dec 22;11(12):e1005343. doi: 10.1371/journal.ppat.1005343. eCollection 2015 Dec. PubMed PMID: 26694741; PubMed Central PMCID: PMC4687929.   
  4. Lim NT, Harder MJ, Kennedy AT, Lin CS, Weir C, Cowman AF, Call MJ, Schmidt CQ, Tham WH. Characterization of Inhibitors and Monoclonal Antibodies That Modulate the Interaction between Plasmodium falciparum Adhesin PfRh4 with Its Erythrocyte  Receptor Complement Receptor 1. J Biol Chem. 2015 Oct 16;290(42):25307-21. doi: 10.1074/jbc.M115.657171. Epub 2015 Aug 31. PubMed PMID: 26324715; PubMed Central  PMCID: PMC4646181.   
  5. Tham WH, Kennedy AT. Malaria: a master lock for deadly parasites. Nature. 2015 Jun 11;522(7555):158-9. doi: 10.1038/522158a. PubMed PMID: 26062503.   
  6. Schmidt CQ, Kennedy AT, Tham WH. More than just immune evasion: Hijacking complement by Plasmodium falciparum. Mol Immunol. 2015 Sep;67(1):71-84. doi: 10.1016/j.molimm.2015.03.006. Epub 2015 Mar 26. Review. PubMed PMID: 25816986.   
  7. Tham WH, Schmidt CQ, Hauhart RE, Guariento M, Tetteh-Quarcoo PB, Lopaticki S,  Atkinson JP, Barlow PN, Cowman AF. Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes. Blood. 2011 Aug 18;118(7):1923-33. doi: 10.1182/blood-2011-03-341305. Epub 2011 Jun 17.  PubMed PMID: 21685372; PubMed Central PMCID: PMC3158720.   
  8. Tham WH, Wilson DW, Lopaticki S, Schmidt CQ, Tetteh-Quarcoo PB, Barlow PN, Richard D, Corbin JE, Beeson JG, Cowman AF. Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17327-32. doi: 10.1073/pnas.1008151107. Epub 2010 Sep 20. PubMed PMID: 20855594; PubMed Central PMCID: PMC2951459.   
  9. Tham WH, Healer J, Cowman AF. Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum. Trends Parasitol. 2012 Jan;28(1):23-30. doi: 10.1016/j.pt.2011.10.002. Epub 2011 Dec 16. Review. PubMed PMID: 22178537.   
  10. Weiss GE, Gilson PR, Taechalertpaisarn T, Tham WH, de Jong NW, Harvey KL, Fowkes FJ, Barlow PN, Rayner JC, Wright GJ, Cowman AF, Crabb BS. Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes. PLoS Pathog. 2015 Feb 27;11(2):e1004670. doi: 10.1371/journal.ppat.1004670. eCollection 2015 Feb. PubMed PMID: 25723550; PubMed Central PMCID: PMC4344246.  

 

More information