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The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release.
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Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.
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Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.
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RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
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Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.
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Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.
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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
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