Hamish King - Publications

Hamish King - Publications

Researcher: 

Selected publications

  1. King HW, Wells KL*, Shipony Z*, Kathiria AS, Wagar LE, Lareau C, Orban N, Capasso R, Davis MM, Steinmetz LM, James LK & Greenleaf WJ§. Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci. bioRxiv. 2021. https://doi.org/10.1101/2021.03.16.435578 (preprint)
  2. King HW§, Orban N, Riches JC, Clear AJ, Warnes G, Teichmann SA & James LK§. Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics. Science Immunology. 2021. 6(56):eabe6291. PMID: 33579751
  3. James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL, King HW, Stares MD, Bareham BR, Ferdinand JR, Petrova VN, Polański K, Forster SC, Jarvis LB, Suchanek O, Howlett S, James LK, Jones JL, Meyer KB, Clatworthy MR, Saeb-Parsy K, Lawley TD & Teichmann SA. Distinct microbial and immune niches of the human colon. Nature Immunology. 2020. 21(3):343-353. PMID: 32066951
  4. Kleshchevnikov V, Shmatko A, Dann E, Aivazidis A, King HW, Li T, Lomakin A, Kedlian V, Jain MS, Park JS, Ramona L, Tuck E, Arutyunyan A, Vento-Tormo R, Gerstung M, James L, Stegle O & Bayraktar OA. Comprehensive mapping of tissue cell architecture via integrated single cell and spatial transcriptomics. bioRxiv. 2020. https://doi.org/10.1101/2020.11.15.378125 (preprint)
  5. Cusack M, King HW, Spingardi P, Kessler BM, Klose RJ & Kriaucionis S. Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors. Genome Research. 2020. 30(10):1393-1406. PMID: 32963030
  6. Fursova NA*, Blackledge NP*, Nakayama M, Ito S, Koseki Y, Farcas AM, King HW, Koseki H & Klose RJ. Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression. Molecular Cell. 2019. 74(5):1020-1036.e8. PMID: 31029541
  7. King HW§, Fursova NA, Blackledge NP & Klose RJ§. Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes. Genome Research. 2018. 28(10):1494-1507. PMID: 30154222
  8. King HW & Klose RJ. The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells. eLife. 2017. 6:e22631. PMID: 28287392
  9. Rose NR*, King HW*, Blackledge NP*, Fursova NA, Ember KJI, Fischer R, Kessler BM & Klose RJ. RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes. eLife. 2016. 5:e18591. PMID: 27705745
  10. Blackledge NP*, Farcas AM*, Kondo T*, King HW, Mcgouran JF, Hanssen LLP, Ito S, Cooper S, Kondo K, Koseki Y, Ishikura T, Long HK, Sheahan TW, Brockdorff N, Kessler BM, Koseki H & Klose RJ. Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation. Cell. 2014. 157(6):1445-1459. PMID: 24856970

* equal contribution

§ corresponding authors