Our current understanding of chromatin-based gene regulation in immune cells relies upon the function of ubiquitously-expressed epigenetic readers and writers. However, specific chromatin readers and writers are uniquely over-expressed or restricted to immune cell lineages.
This project aims to identify such chromatin-associated factors and investigate how and where they interact with the epigenomes of different immune cell lineages.
We leverage both in vitro and ex vivo immune cell culture methods, combined with cutting edge bulk and single-cell genomics to understand how normal, and disease-specific, gene regulatory networks are defined and controlled by chromatin readers and writers.