Selected publications

1. Ke F, Vanyai H, Cowan A, Whitehead L, Delbridge AR, Grabow S, Czabotar P, Voss AK, Strasser A. Rare instances of embryogenesis and adult life in the absence of the intrinsic apoptosis effectors BAX, BAK and BOK. Cell. 2018 (in press)
2. Janic A, Valente LJ, Wakefield MJ, Di Stefano L, Milla L, Wilcox S, Yang H, Tai L, Vandenberg CJ, Kueh AJ, Mizutani S, Brennan MS, Schenk RL, Lindqvist LM, Papenfuss AT, O’Connor L, Strasser A, Herold MJ. Sensitised in vivo shRNA screens identify effectors of p53-mediated tumour suppression and reveal a critical role of DNA repair. Nature Medicine. 2018 (in press)
3. Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kely GL, Gong J, Moujalled D, Bruno A, Csekei M, Paczal A, Szabo Z, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dukorno P, Chen I, Matassova N, Smith J, Pedder C, Graham C, Studeny A, Lysiak-Auvity G, Girard A-M, Grave F, Segal D, Riffkin CD, Pomilio G, Brennan MS, Herold MJ, Chang C, Guasconi G, Cauquil N, Melchiore F, Guigal-Stephan N, Lockhart B, Colland F, Hickman JA, Roberts AW, Huang DCS, Wei A, Strasser A, Lessene G, Geneste O. Potent and selective MCL1 inhibition is tolerable and efficacious in multiple cancer models. Nature. 2016 Oct 27;538(7626):477-482. PMID: 27760111.
4. Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature. 2009 Aug 20;460(7258):1035-9. PMID: 19626005.
5. Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, Strasser A. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell. 2007 Jun 29;129(7):1337-49. PMID: 17604722.
6. Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ, Adams JM, Strasser A. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science. 2003 Nov 7;302(5647):1036-8. PMID: 14500851.
7. Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JM, Strasser A. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science. 1999 Nov 26;286(5445):1735-8. PMID: 10576740.
8. Strasser A, Harris AW, Cory S. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell. 1991 Nov 29;67(5):889-99. PMID: 1959134.
9. Strasser A, Whittingham S, Vaux DL, Bath ML, Adams JM, Cory S, Harris AW. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA. 1991 Oct 1;88(19):8661-5. PMID: 1924327.
10. Strasser A, Harris AW, Bath ML, Cory S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature. 1990 Nov 22;348(6299):331-3. PMID: 2250704.

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