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Parkinson’s Disease Research Centre

Accelerating the development of diagnostics and new drugs to stop Parkinson’s disease.

The Parkinson’s Disease Research Centre is a collaborative, multi-disciplinary initiative to develop early diagnostic tests and new drugs to improve the lives of people living with Parkinson’s disease.

Our goals are to discover the fundamental mechanisms driving neurodegeneration in Parkinson’s disease and identify blood biomarkers.

Over 200,000 Australians have Parkinson’s
1 person diagnosed every 30 minutes
World’s fastest growing neurological disorder
Cases expected to double in 15 years
No clinical diagnostic test
No drugs to slow or stop progression

The science of Parkinson’s disease

Parkinson’s disease is complex with symptoms varying from person to person in both type and severity. Symptoms can predate clinical diagnosis by years, even decades.

Movement symptoms in Parkinson’s are caused by the death of dopaminergic neurons in the brain. When these brain cells die, the rate at which they are replaced slows as we age.

When the processes that manage cell death, energy production and recycling become dysfunctional, they can lead to the build-up of proteins, such as alpha-synuclein.

When this occurs, it creates a vicious cycle that leads to neurodegenerative diseases including Parkinson’s. Because there is no clinical diagnostic test, diagnosis and treatment is almost impossible in the very early stages of the disease.

Our approach

Our approach capitalises on decades of world-leading research into cell death and immunology at WEHI. To date, most research into Parkinson’s has focussed on controlling symptoms, not stopping disease progression which involves the death of brain cells.

Our unique multi-disciplinary approach brings together world-leading researchers in cell death, mitochondrial function and ubiquitin signalling in the same institute. These three areas are central to stopping Parkinson’s.

“We know why some cells don’t die when they should, and that knowledge has helped kill cancer cells. Our goal is now to stop brain cells dying when they shouldn’t in Parkinson’s.” 
Professor Grant Dewson
Head, Parkinsons Disease Research Centre

Multidisciplined collaboration

The Parkinson’s Disease Research Centre currently has nine labs, dedicated support staff and a team of consumer advocates. We work collaboratively with leading movement disorder clinicians in Melbourne and researchers around the world in programs including Aligning Science Across Parkinson’s and the Global Parkinson’s Genetic Program.

Our team members are leading projects alongside other researchers from institutions including NeuRA, The Florey, UC Berkley, Max Planck Insitute and the University of Vienna.

Scientific entrepreneurship

Members of our leadership team have built links to the pharmaceutical industry, by establishing spin-out companies to accelerate the translation of their research into viable drug therapies through clinical trials.

Partnering with organisations that have access to venture capital provides the Centre with the ability to explore future discoveries in conjunction with WEHI’s National Drug Discovery Centre.

Centre funding and supporters

The centre is funded by grants from Parkinson’s-specific funding bodies and philanthropic donations. This funding is used to support salaries for staff, from PhD stipends through to lab heads, and allowing the purchase of equipment.

These grants and generous donations are central to our ongoing success.

Your support can help accelerate life-changing medical research for Parkinson’s disease and other debilitating conditions.

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