Longley Lab leverages naturally acquired immune responses against infections, particularly malaria, for both novel surveillance tools and development of vaccines. Our work uses immunological and epidemiological approaches and is underpinned by equitable partnerships with researchers in disease-endemic countries.
Tham Lab has made fundamental discoveries in novel host-pathogen interactions and examined their molecular and structural mechanisms to drive rational design of new therapies against infectious diseases against malaria parasites and viruses. Our work intersects with the fields of structural biology, nanobody technology and development of functional-blocking assays.
References:
Longley, Nat Med 2020 26(5):741-749
Bareng and Wu, bioRxiv 2025 https://doi.org/10.1101/2025.07.07.663616
Gruszczyk, Science 2018 359(6371):48-55.
Pymm and Adair, Proc Natl Acad Sci U S A. 2021 11;118(19):e2101918118.