CAR T cell therapy has transformed the treatment of blood cancers, producing remarkable clinical responses in patients. However, many patients still relapse or experience severe toxicities, highlighting the need for safer and more effective CAR designs.
This project will explore a novel split CAR T cell platform that separates key signalling components into distinct receptor modules to better control T cell activation. Using protein engineering and structural biology approaches, the student will investigate how CAR architecture influences signalling and anti-tumour function to improve the safety and efficacy of CAR T cell therapy.
This project is ideal for students interested in immunology, structural biology and cancer research. Students will gain experience in molecular cloning, mammalian cell culture, flow cytometry and functional immune assays.
