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About

There are five clear areas of focus for the translational research undertaken by the Gibbs Lab.

* We lead national and international cancer registries that capture comprehensive patient, tumour, treatment and outcome data for all major solid cancers. This data is used to enable audit and research, including supporting the novel concept of registry based clinical trials in oncology collection and translational research by combining data and tissue based research.

* More recently the Gibbs Lab have partnered with the Victorian Comprehensive Cancer Centre (VCCC) to undertake a number of registry-based trials. This work is ongoing with a number of new trial designs under review for inclusion as we expand the portfolio to different modalities of treatment of patients with cancer

* We lead multiple international randomised trials to define the potential of ctDNA as a marker of minimal residual disease to determine recurrence risk and to optimise adjuvant therapy.

* We have initiated studies of patient derived tumour organoids, with the ultimate aim of in vitro sensitivity testing being used to guide clinical treatment selection.

* Clinical Trials working with cooperative groups such as the AGITG and others to provide all aspects of clinical trial start up, initiation, study management to data analysis and close out.

Each program is led by a medical oncologist with appropriate sub-speciality expertise and substantial clinical appointments, with the ultimate focus being clinical relevance and impact.

Publications

Selected publications from Prof Peter Gibbs

Tie J, Kinde I, Wang Y, Wong H, Roebert J, Christie M, Tacey M, Wong R, Singh M, Karapetis C, Desai J, Tran B, Strausberg R, Diaz L, Papadopoulos N, Kinzler K, Vogelstein B, Gibbs P. Circulating Tumor DNA as an Early Marker of Therapeutic Response in Patients with Metastatic Colorectal Cancer. Ann Oncol. 26;1715-22:2015

Tie J, Wang Y, Springer S, Kinde I, Wong HL, Christie M, Tacey M, Kosmider S, Skinner I, Wong R, Steel M, Tran B, Desai J, Jones I, Haydon A, Price T, Hayes T, Strausberg R, Diaz L, Papadopoulos N, Kinzler K, Vogelstein B, Gibbs P. Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer. Sci Transl Med. 8;346:2016.

Tie J, Cohen J, Wang Y, Li L, Kinde I, Elsaleh H, Wong R, Kosmider S, Yip D, Lee M, Tran B, Burge M, Goldstein D, Singh M, Diaz L, Tomasetti C, Papadopoulos N, Kinzler K, Vogelstein B, Gibbs P. Serial Circulating Tumor DNA Analysis During Multimodality Treatment of Locally Advanced Rectal Cancer: A Prospective Biomarker Study. Gut 68;663-671:2019

Tie J, Cohen J, Wang Y, Christie M, Simons K, Lee M, Wong R, Kosmider S, Ananda S, McKendrick J, Lee B, Cho J, Faragher I, Jones I, Ptak J, Schaeffer J, Silliman N, Dobyn L, Li L, Tomasetti C, Papadopoulos N, Kinzler K, Vogelstein B, Gibbs P. Circulating tumor DNA analyses as markers of recurrence risk and adjuvant therapy benefit for stage III colon cancer. JAMA Oncol 5;1710-7:2019

Tie J, Cohen J, Lo S, Wang Y, Li L, Christie M, Lee M, Wong R, Kosmider S, Skinner I, Wong H, Lee B, Burge B, Yip D, Karapetis C, Price T, Tebbutt N, Haydon A, Ptak J, Schaeffer M, Silliman N, Dobbyn L, Tomasetti C, Papadopoulos N, Kinzler K, Vogelstein B, Gibbs P. Prognostic Significance of Post-Surgery Circulating Tumor DNA in Non-Metastatic Colorectal Cancer: Individual Patient Pooled Analysis of Three Cohort Studies. Int J Cancer 148;1014-26:2021

Tie J, Wang Y, Cohen J, Li L, Hong W, Christie M, Wong H, Kosmider S, Wong R, Thomson B, Choi J, Field K, Burge M, Shannaon J, Kotasek D, Tebbut N, Underhill C, Haydon A, Shapiro J, Tomasetti C, Papadopoulos N, Kinzler K, Vogelstein B, Gibbs P. Circulating tumor DNA dynamics inform recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases. PLOS Medicine 18;e1003620:2021

Tie J, Cohen J, Lahouel K, Lo S, Wang Y, Kosmider S, Wong R, Shapiro J, Lee M, Harris S, Khattak A, Burge M, Harris M, Lynam J, Nott L, Day F, Hayes T, McLachlan S, Lee B, Ptak J, Silliman N, Dobbyn L, Popoli M, Hruban R, O’Broin-Lennon A, Papadopoulos N, Tomasetti C, Kinzler K, Vogelstein B, Gibbs P. Chemotherapy Directed By Circulating Tumor DNA Analysis in Stage II Colorectal Cancer. N Engl J Med 386:2261-72:2022

Lab research projects

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