Cell Death and Infection

Our body has evolved incredible strategies to fight off the plethora of pathogens we are facing on a daily basis. One of these is programmed cell death, a process that aims at removing infected cells, thereby killing the pathogen and priming our immune system.

Our research aims at understanding how this remarkable process is regulated on a molecular level, and to harness and translate this knowledge into new treatments for chronic and acute viral and bacterial infections including tuberculosis, HIV, COVID-19 or dengue.

Our mission is help improve patient outcomes through the development of new treatment options for some of the world’s most notorious pathogens.

Using novel technology such as CRISPR screening tools and transcriptome sequencing, we have identified that programmed cell death is regulated by flexible networks during intracellular infection. This changes the way we think about cell death, and how we can utilize its powers to control infection.